Inhibition of acute rejection after skin or cardiac transplantation by administration of donor antigens in the rat.

Abstract:

PURPOSE:We examined differences in host immunologic changes induced by the intravenous or intraportal administration of donor antigens at engrafting and evaluated their contribution to graft survival using a rat transplantation model. METHODS:Lewis rat recipients were given either an intravenous or intraportal injection of donor splenocytes (1 x 10(8)) immediately after receiving skin grafts from Brown Norway donors. The immunologic responses were analyzed by mixed lymphocyte reaction (MLR) and profiles of interferon-Gamma, interleukin (IL)-2, and IL-10 in MLR supernatants. The effect on cardiac transplantation of perioperative administration of low-dose FK506 (0.1 mg/kg per day) was also examined. RESULTS:Mixed lymphocyte reactions using splenocytes and sera from recipients treated intraportally were greatly inhibited. Interferon-gamma, IL-2, and IL-10 levels were significantly higher after intraportal treatment compared with intravenous treatment (P < 0.05). When FK506 was injected from day 3, a significant enhancement of cardiac allograft survival was demonstrated by intraportal treatment (16.1 +/- 2.9 days) in comparison to the non-treatment (13.0 +/- 1.7 days, P < 0.05) and intravenous treatment rats (11.7 +/- 2.7 days, P < 0.05). CONCLUSIONS:The Th2 deviation induced with intraportal alloantigen administration immediately after engraftment was thus observed to produce a synergistic effect with immunosuppressant treatment to suppress acute rejection.

journal_name

Surg Today

journal_title

Surgery today

authors

Shirouzu Y,Hikida S,Tanigawa H,Shirouzu K

doi

10.1007/s00595-003-2701-5

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

341-8

issue

4

eissn

0941-1291

issn

1436-2813

journal_volume

34

pub_type

杂志文章
  • c-Met expression in a gastric cancer cell line producing alpha-fetoprotein.

    abstract:PURPOSE:We previously reported a higher frequency of c-Met protein expression and high proliferative status in gastric cancers producing alpha-fetoprotein (AFP) than in those not producing AFP. METHODS:To investigate this further, we established an AFP-producing gastric cancer cell line, designated as AME-1, from the ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-003-2668-2

    authors: Amemiya H,Kono K,Takahashi A,Kamei S,Sugai H,Ichihara F,Fujii H,Matsumoto Y

    更新日期:2004-01-01 00:00:00

  • Primary stent placement for late complete occlusion after aortoiliac reconstructive surgery: report of a case.

    abstract::We report a case that was successfully treated by primary stent placement without thrombolysis or thrombectomy for graft thrombosis after aortoiliac reconstructive surgery. A 79-year-old man presented with a 2-month history of severe intermittent claudication of the right leg. He had undergone a surgical repair of abd...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-008-3855-y

    authors: Kondo Y,Dardik A,Muto A,Nishibe M,Nishibe T

    更新日期:2009-01-01 00:00:00

  • Usefulness of staging laparoscopy for advanced gastric cancer.

    abstract:PURPOSE:The aim of this study was to clarify the usefulness of staging laparoscopy for planning the treatment strategy in patients with advanced gastric cancer. METHODS:This was a retrospective study of patients with gastric cancer who underwent staging laparoscopy. The patients were divided into three groups accordin...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-009-4017-6

    authors: Shimizu H,Imamura H,Ohta K,Miyazaki Y,Kishimoto T,Fukunaga M,Ohzato H,Tatsuta M,Furukawa H

    更新日期:2010-01-01 00:00:00

  • Secundum atrial septal defect associated with mitral valve cleft: report of a case with chromosomal syndrome of trisomy 3p.

    abstract::A 4-year-old boy was diagnosed as having a chromosomal abnormality with trisomy 3p associated with a secundum atrial septal defect and a cleft of the anterior mitral leaflet. His craniofacial features showed microcephaly, micrognathia, ocular hypertelorism associated with epicanthus, and low-set ears. Moderate mental ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF00312096

    authors: Suzuki M,Ishikawa S,Ohtaki A,Sakata K,Kawashima O,Otani Y,Morishita Y

    更新日期:1996-01-01 00:00:00

  • Second primary digestive cancer after resection of lung cancer.

    abstract:PURPOSE:We evaluated the clinical findings of patients with second primary digestive cancers (SPDC) after the resection of lung cancer. METHODS:Among 772 patients who underwent resection of primary lung cancer at Saitama Cardiovascular and Respiratory Center between 1993 and 2002, 10 (1.3%) were diagnosed with SPDC du...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-004-2762-0

    authors: Kamiyama H,Ikeya T,Suda K,Murai K,Aoyama K,Hoshi E

    更新日期:2004-01-01 00:00:00

  • Preoperative liver function assessments to estimate the prognosis and safety of liver resections.

    abstract::Liver function assessment is important to ensure safe surgical procedures in patients with hepatocellular disease. Because the liver influences a wide variety of functions, including protein synthesis and metabolic, immune and storage functions, no single parameter is sufficient to adequately address all of these func...

    journal_title:Surgery today

    pub_type: 杂志文章,评审

    doi:10.1007/s00595-013-0534-4

    authors: Mizuguchi T,Kawamoto M,Meguro M,Hui TT,Hirata K

    更新日期:2014-01-01 00:00:00

  • Efficacy of transumbilical laparoscopic-assisted appendectomy for appendicitis: a four-year experience at a single center.

    abstract:PURPOSE:To compare the surgical outcomes after transumbilical laparoscopic-assisted appendectomy (TULAA) and open appendectomy (OA) at a single institution. METHODS:We compared the surgical outcomes for 94 consecutive patients who underwent TULAA between April 2010 and March 2014 to those for 91 consecutive patients w...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-014-1034-x

    authors: Koizumi N,Kobayashi H,Nakase Y,Takagi T,Fukumoto K

    更新日期:2015-10-01 00:00:00

  • Protective effect of a lipoxygenase inhibitor, nordihydroguaretic acid, on the ileal motor disturbances induced by Serratia marcescens endotoxin in rats.

    abstract::This study was conducted to examine the effects of peptidoleukotrienes on the ileal contractility disturbances induced by Serratia marcescens endotoxin in rats. Thirty-two male Wistar rats were divided into four groups (n = 8 each). The first group was given only an anesthetic agent (control group); the second group w...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950170108

    authors: Ezberci F,Tekin E,Onuk E

    更新日期:2001-01-01 00:00:00

  • Occurrence of intraperitoneal septic complications after hepatic resections between 1985 and 1990.

    abstract::In this study, the risk factors related to intraperitoneal septic complications occurring after hepatectomy (IPSCH) as well as the effect of various perioperative variables on the outcome of IPSCH between 1985 and 1990 were analyzed. Twenty-one of 211 patients (10.0%) developed IPSCH. The findings in the patients with...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF00309385

    authors: Matsumata T,Yanaga K,Shimada M,Shirabe K,Taketomi A,Sugimachi K

    更新日期:1995-01-01 00:00:00

  • Fissurectomy with posterior midline sphincterotomy and anoplasty (FPSA) in the management of chronic anal fissures.

    abstract::Although lateral internal sphincterotomy is widely accepted as the treatment of choice for anal fissures, we report our experience of successfully treating 195 consecutive patients with posterior chronic anal fissures by performing fissurectomy with midline sphincterotomy and anoplasty (FPSA). The surgical technique i...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF02388152

    authors: Di Castro A,Biancari F,D'Andrea V,Caviglia A

    更新日期:1997-01-01 00:00:00

  • Uncontrollable intra-abdominal bleeding necessitating low anterior resection of the rectum after stapled hemorrhoidopexy: report of a case.

    abstract::Stapled hemorrhoidopexy (SH) has become a widely accepted surgical procedure for hemorrhoids; however, one of the most serious complications of this technique is severe bleeding. We report a case of extensive hemoperitoneum after SH for third-degree hemorrhoids. On postoperative day (POD) 1, the patient complained of ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-006-3363-x

    authors: Blouhos K,Vasiliadis K,Tsalis K,Botsios D,Vrakas X

    更新日期:2007-01-01 00:00:00

  • Transsacral rectopexy for recurrent complete rectal prolapse.

    abstract::The aim of this study was to examine the functional outcome of transsacral rectopexy performed with Dexon mesh for recurrent complete rectal prolapse. Anorectal function was assessed by anorectal manometry and defecography, before and from 1 year after surgery in five patients who were followed up for 1-3 years. The f...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF02482800

    authors: Araki Y,Isomoto H,Tsuzi Y,Matsumoto A,Yasunaga M,Yamauchi K,Hayashi K,Kodama T

    更新日期:1999-01-01 00:00:00

  • Spontaneous regression of a metastatic liver tumor: report of a case.

    abstract::A 60-year-old man, who suffered from advanced rectal cancer accompanied with liver metastasis, underwent an abdominoperineal resection and a partial hepatectomy. He remained well until 4 months after surgery when he developed a biopsy-proven recurrent intrapelvic mass and multiple liver tumors. At 6 months after surge...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950200165

    authors: Ikuta S,Miki C,Ookura E,Tonouchi H,Kusunoki M

    更新日期:2002-01-01 00:00:00

  • Laparoscopic left-sided Nissen fundoplication in children.

    abstract::It is sometimes difficult or inappropriate to adopt the standard surgical steps of adult laparoscopic procedures in pediatric patients because of the inevitably smaller anatomical structures and confined intra-abdominal working space. During laparoscopic Nissen fundoplication difficulties are usually encountered, espe...

    journal_title:Surgery today

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00595-004-2760-2

    authors: Nakajima K,Kawahara H,Wasa M,Soh H,Taniguchi E,Ohashi S,Okada A

    更新日期:2004-01-01 00:00:00

  • Giant esophageal gastrointestinal stromal tumor: report of a case.

    abstract::Gastrointestinal stromal tumors (GISTs) rarely arise in the esophagus, where carcinoma is the most common malignant neoplasm and leiomyoma is the most common benign tumor. Because of their rarity, the clinical course and treatment of esophageal GISTs are poorly understood. These lesions are generally thought to carry ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-014-0929-x

    authors: Nakano A,Akutsu Y,Shuto K,Uesato M,Kono T,Hoshino I,Akanuma N,Maruyama T,Isozaki Y,Matsubara H

    更新日期:2015-02-01 00:00:00

  • Primary malignant fibrous histiocytoma of the small intestine presenting as an intussusception: report of a case.

    abstract::Malignant fibrous histiocytoma occurs most commonly in the extremities and trunk, but rarely in the visceral organs. Malignant fibrous histiocytoma of the small intestine is an extremely rare condition. To our knowledge, only ten cases of primary tumors involving the small intestine have been described up to now. Amon...

    journal_title:Surgery today

    pub_type: 杂志文章,评审

    doi:10.1007/s005950200221

    authors: Kotan C,Kosem M,Alici S,Ilhan M,Tuncer I,Harman M

    更新日期:2002-01-01 00:00:00

  • Repeated colon penetration by an ingested fish bone: report of a case.

    abstract::A 78-year-old man was admitted to Kumamoto Rosai Hospital with right lower abdominal pain. Abdominal computed tomography (CT) showed penetration of the cecum by a foreign body, which looked like a fish bone, as well as thickening of the right lower abdominal wall. We made an initial diagnosis of penetration of the col...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-007-3629-y

    authors: Okuma T,Nagamoto N,Tanaka E,Yoshida Y,Inoue K,Baba H

    更新日期:2008-01-01 00:00:00

  • Increased plasma concentration of adrenomedullin during and after major surgery.

    abstract::Adrenomedullin (AM), a novel vasodilatory peptide, appears to participate in the regulation of circulation. Recent studies have reported a relationship between AM and cytokine. The present study was performed to determine whether major surgery, which is accompanied by an altered cytokine production, affects the concen...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950170089

    authors: Fujioka S

    更新日期:2001-01-01 00:00:00

  • The development of a pyogenic liver abscess following radical resection of cholangiocellular carcinoma with ligation of the right hepatic artery: report of a case.

    abstract::We present herein the case of a pyogenic liver abscess developing from hepatic ischemia caused by resection of the right hepatic artery when a left hemihepatectomy with caudate lobectomy and extrahepatic bile duct resection was performed for cholangiocellular carcinoma. Postoperative cholangiography revealed communica...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF01833737

    authors: Tanaka K,Nishimura A,Hombo K,Furoi A,Ikoma A,Yamauchi T,Taira A

    更新日期:1994-01-01 00:00:00

  • Educational application of intraoperative records from an energy device in laparoscopic gastrectomy: a preliminary report.

    abstract:PURPOSE:Video review is a reliable method for surgical education in laparoscopic gastrectomy (LG), but more objective methods are still needed. The purpose of this study was to determine whether the energy device records reflected surgical competency, and thereby may improve surgical education. METHODS:A total of 16 p...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-020-02160-x

    authors: Hosogi H,Obama K,Tsunoda S,Hisamori S,Nishigori T,Tanaka E,Satoh S,Okabe H,Kanaya S,Sakai Y

    更新日期:2020-10-11 00:00:00

  • Surgical treatment of giant liver hydatid cysts: comparison of cystojejunostomy and partial cystectomy.

    abstract:PURPOSE:The aim of this study was to compare partial cystectomy and internal drainage of the cyst cavity with cystojejunostomy for the surgical treatment of giant hepatic hydatid cysts. METHODS:Patients who underwent any type of surgical treatment between March 2009 and May 2013 for giant hepatic hydatid cysts were re...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-014-0887-3

    authors: Acar F,Sahin M,Alptekin H,Yılmaz H,Kafalı ME

    更新日期:2014-11-01 00:00:00

  • Effects of calcium in continuous cardioplegia on myocardial protection.

    abstract::The effects of calcium (Ca) on a hyperkalemic cardioplegic solution for continuous cardioplegia were examined in an isolated perfused working rat heart model. The coronary arteries were perfused with a modified Krebs-Henseleit bicarbonate buffer (K-H) solution, containing various concentrations of Ca (0.1, 0.6, 1.2, a...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF00311503

    authors: Takemoto N,Kuroda H,Nakamura Y,Ichiba T,Matsuda N,Ashida Y,Hamasaki T,Hara Y,Ishiguro S,Mori T

    更新日期:1996-01-01 00:00:00

  • Dissociation between T helper type 1 and type 2 differentiation and cytokine production in tumor-infiltrating lymphocytes in patients with lung cancer.

    abstract::We recently reported the balance of T helper type 1 (Th1) cells and type 2 (Th2) cells in patients with lung carcinomas. This study was conducted to investigate their activity and role in tumors, which remain unclear. We determined the population of lymphocytes with intracellular interferon (IFN)-gamma or interleukin ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950170127

    authors: Ito N,Nakamura H,Metsugi H,Ohgi S

    更新日期:2001-01-01 00:00:00

  • An experimental study on spinal cord ischemia during cross-clamping of the thoracic aorta: the monitoring of spinal cord ischemia with motor evoked potential by transcranial stimulation of the cerebral cortex in dogs.

    abstract::The usefulness of spinal motor evoked potential by transcranial stimulation of the motor cortex (MEPT) in detecting spinal ischemia and predicting postoperative neurological dysfunction was evaluated using a model of spinal ischemia. Group 1 was comprised of 11 dogs used for measuring the basic wave form of spinal MEP...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF00309095

    authors: Shokoku S,Uchida H,Teramoto S

    更新日期:1993-01-01 00:00:00

  • Current status of robotic gastrectomy for gastric cancer.

    abstract::Although over 3000 da Vinci Surgical System (DVSS) devices have been installed worldwide, robotic surgery for gastric cancer has not yet become widely spread and is only available in several advanced institutions. This is because, at least in part, the advantages of robotic surgery for gastric cancer remain unclear. T...

    journal_title:Surgery today

    pub_type: 杂志文章,评审

    doi:10.1007/s00595-015-1190-7

    authors: Obama K,Sakai Y

    更新日期:2016-05-01 00:00:00

  • The enhanced therapeutic efficacy of intra-arterial cis-diamminedichloroplatinum (II) chemotherapy in combination with aortic clamping on metastatic hepatic tumors in the rat.

    abstract::The efficacy of intrahepatic cis-diamminedichloroplatinum (II), cisplatin, administered via the hepatic artery in combination with concomitant clamping of the abdominal aorta beneath the diaphragm against metastatic liver tumors in rats was evaluated. When 2.5 or 5 mg/kg of cisplatin was injected intra-arterially (i.a...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF02473393

    authors: Nishioka Y

    更新日期:1994-01-01 00:00:00

  • Esophago-jejuno-duodenal anastomoses with an ultra-short duodenum.

    abstract::Reconstruction following total gastrectomy usually requires one of the various methods of esophagojejunal anastomosis. We present herein the case of a 78-year-old woman with gastric carcinoma involving the adjacent organs for which resection of the whole stomach, distal pancreas, transverse colon, and distal duodenum ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF00308986

    authors: Akimaru K,Kokuma M,Hideshima A,Gotoh M,Shibuya T,Shoji T

    更新日期:1993-01-01 00:00:00

  • Gastric perforation caused by a bulimic attack in an anorexia nervosa patient: report of a case.

    abstract::We report a rare case of gastric perforation due to a bulimic attack in a 17-year-old girl suffering from anorexia nervosa. She was admitted to our hospital with the chief complaint of abdominal pain following bulimia. Initially, her symptoms were reduced after drainage using a nasogastric tube. Eight hours later, how...

    journal_title:Surgery today

    pub_type: 杂志文章,评审

    doi:10.1007/s005950050618

    authors: Nakao A,Isozaki H,Iwagaki H,Kanagawa T,Takakura N,Tanaka N

    更新日期:2000-01-01 00:00:00

  • The role of fine-needle aspiration and intraoperative frozen section in the surgical management of solitary thyroid nodules.

    abstract:PURPOSE:We evaluated the role of intraoperative frozen section (FS) in the surgical management of solitary thyroid nodules, as its true value is a subject of some controversy. METHODS:We reviewed the records of 206 consecutive patients operated on for solitary thyroid nodules. All patients had undergone both preoperat...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950200167

    authors: Duek SD,Goldenberg D,Linn S,Krausz MM,Hershko DD

    更新日期:2002-01-01 00:00:00

  • Infected pancreatic necrosis after extraperitoneal abdominal aortic aneurysm repair: report of a case.

    abstract::We report a case of acute necrotizing pancreatitis after extraperitoneal repair of an abdominal aortic aneurysm (AAA). Acute pancreatitis (AP) is an uncommon complication of vascular surgery; however, managing its local and general consequences, including the eventual pancreatic abscess and the risk of prosthetic infe...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-007-3668-4

    authors: Ferrante A,Cina A,Snider F

    更新日期:2008-01-01 00:00:00