Abstract:
:The efficacy of intrahepatic cis-diamminedichloroplatinum (II), cisplatin, administered via the hepatic artery in combination with concomitant clamping of the abdominal aorta beneath the diaphragm against metastatic liver tumors in rats was evaluated. When 2.5 or 5 mg/kg of cisplatin was injected intra-arterially (i.a.) over 5 min, the antitumor activities in the rats with aortic clamping, evaluated by the number of tumor nodules and survival days after treatment, were found to be superior to those in the rats without aortic clamping. Side effects, evaluated in terms of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase levels, changes in body weight, and the number of leukocytes, did not differ significantly among the rats with or without aortic clamping. The blood urea nitrogen levels observed in the rats with aortic clamping were lower than in those without aortic clamping. Immediately after the injection of cisplatin 5 mg/kg i.a., the platinum concentrations in the livers of rats with aortic clamping were approximately 2.1 times higher than in those without aortic clamping, and 1.4 times higher even 60 min after the injection. These increased platinum concentrations in the liver explain the enhanced antitumor activities of the rats given cisplatin with aortic clamping.
journal_name
Surg Todayjournal_title
Surgery todayauthors
Nishioka Ydoi
10.1007/BF02473393subject
Has Abstractpub_date
1994-01-01 00:00:00pages
128-32issue
2eissn
0941-1291issn
1436-2813journal_volume
24pub_type
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