Contribution of nitric oxide produced by inducible nitric oxide synthase to vascular responses of mesenteric arterioles in streptozotocin-diabetic rats.

abstract：:Lignocaine suppresses insulin-stimulated glucose transport into the cells and insulin-stimulated glycogenesis at doses equivalent to that used in the treatment of muscle pain disorder. We evaluated the direct effect of lignocaine on insulin receptor (IR) kinase activity. After lignocaine (40 mM, approximately equivale...

journal_title：British journal of pharmacology

authors： Hirose M,Martyn JA,Kuroda Y,Marunaka Y,Tanaka Y

更新日期：2002-05-01 00:00:00

abstract：:1. Inhibition of rat platelet aggregation by the nitric oxide (NO) donor MAHMA NONOate (Z-1-N-methyl-N-[6-(N-methylammoniohexyl)amino]diazen-1-ium-1,2-diolate) was investigated. The aims were to compare its anti-aggregatory effect with vasorelaxation, to determine the effects of the soluble guanylate cyclase inhibitor...

journal_title：British journal of pharmacology

authors： Homer KL,Wanstall JC

更新日期：2002-12-01 00:00:00

abstract：:1 About 45% of singly-housed male mice showed timidity (alert postures, running away, defensive postures) instead of aggression on interactions in pairs with group-housed male mice, though their partners did not show any aggression. The isolation-induced timidity was stable in repeated interactions. Timid mice also sh...

journal_title：British journal of pharmacology

authors： Krsiak M

更新日期：1975-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of the present study was to assess the interaction of nitrergic neurotransmission within the bed nucleus of the stria terminalis (BNST) with local glutamatergic and noradrenergic neurotransmission in the control of cardiovascular responses to acute restraint stress in rats. EXPERIMENTAL ...

journal_title：British journal of pharmacology

authors： Barretto-de-Souza L,Adami MB,Benini R,Crestani CC

更新日期：2018-10-01 00:00:00

abstract：:1. Electrically-evoked contractions in different regions of the rabbit isolated pulmonary artery have been investigated using stimulation parameters generally assumed to stimulate nerves selectively. 2. In extrapulmonary artery, trains of stimuli (10 Hz; pulse width 0.1 ms) evoked monophasic contractions. In contrast,...

journal_title：British journal of pharmacology

authors： Jackson VM,Trout SJ,Cunnane TC

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Dexpramipexole, a drug recently tested in patients with amyotrophic lateral sclerosis (ALS,) is able to bind F1Fo ATP synthase and increase mitochondrial ATP production. Here, we have investigated its effects on experimental ischaemic brain injury. EXPERIMENTAL APPROACH:The effects of dexpramipe...

journal_title：British journal of pharmacology

authors： Muzzi M,Gerace E,Buonvicino D,Coppi E,Resta F,Formentini L,Zecchi R,Tigli L,Guasti D,Ferri M,Camaioni E,Masi A,Pellegrini-Giampietro DE,Mannaioni G,Bani D,Pugliese AM,Chiarugi A

更新日期：2018-01-01 00:00:00

abstract：:1. Antilaminin IgG decreased the dF/dt of mouse isolated atria and inhibited the mechanical effect of acetylcholine in a non-competitive fashion. 2. Inhibitors of nicotinic and muscarinic cholinoceptors impaired the negative inotropic action of antilaminin IgG in mouse isolated atria. Hemicholinium and tetrodotoxin al...

journal_title：British journal of pharmacology

authors： Bacman S,Borda E,Denduchis B,Lustig L,Sterin-Borda L

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The effects of 4-O-methylhonokiol (MH), a constituent of Magnolia officinalis, were investigated on human prostate cancer cells and its mechanism of action elucidated. EXPERIMENTAL APPROACH:The anti-cancer effects of MH were examined in prostate cancer and normal cells. The effects were validate...

journal_title：British journal of pharmacology

authors： Lee NJ,Oh JH,Ban JO,Shim JH,Lee HP,Jung JK,Ahn BW,Yoon DY,Han SB,Ham YW,Hong JT

更新日期：2013-03-01 00:00:00

abstract：:1. The pharmacokinetics of cyclophosphamide were investigated in cancer patients. The data can be characterized by a two-compartment open model. The half life of the elimination phase of the drug ranged between 3 and 11 hours.2. Extensive tubular reabsorption of the drug resulted in the excretion of only a small perce...

journal_title：British journal of pharmacology

authors： Cohen JL,Jao JY,Jusko WJ

更新日期：1971-11-01 00:00:00

abstract：:1 The putative 5-hydroxytryptamine (5-HT) receptor blocking drugs methysergide (10 mg/kg) and methergoline (5 mg/kg) were found to abolish some components of the hyperactivity syndrome, including head weaving and forepaw treading, which follow administration to rats of tranylcypromine (20 mg/kg) and L-tryptophan (100 ...

journal_title：British journal of pharmacology

authors： Deakin JF,Green AR

更新日期：1978-10-01 00:00:00

abstract：:1. We have characterized the human smooth muscle endothelin converting enzyme (ECE) present in the media of the endothelium-denuded human umbilical vein preparation. 2. Endothelin-1 (ET-1) and ET-2 were potent constrictors of umbilical vein with EC50 values of 9.2 nM and 29.6 nM, respectively. ET-1 was at least 30 tim...

journal_title：British journal of pharmacology

authors： Maguire JJ,Johnson CM,Mockridge JW,Davenport AP

更新日期：1997-12-01 00:00:00

abstract：:Halothane has many effects on the resting membrane potential (V(m)) of excitable cells and exerts numerous effects on skeletal muscle one of which is the enhancement of Ca(2+) release by the sarcoplasmic reticulum (SR) resulting in a sustained contracture. The aim of this study was to analyse the effects of clinical d...

journal_title：British journal of pharmacology

authors： Sauviat MP,Frizelle HP,Descorps-Declère A,Mazoit JX

更新日期：2000-06-01 00:00:00

abstract：:1 Core and tail skin temperature was measured in rats which had guide cannulae implanted into their brains to allow drug injections directly into the preoptic anterior hypothalamus. 2 Apomorphine and dopamine (10 microgram in 1 microliter) injected into the area of the preoptic anterior hypothalamus caused a fall in c...

journal_title：British journal of pharmacology

authors： Cox B,Lee TF

更新日期：1977-09-01 00:00:00

abstract：:1. Leukotriene B(4) (LTB(4)) stimulation of guinea-pig peritoneal eosinophils, induced a biphasic activation of the NADPH oxidase composed of a rapid (<3 min) phase mediated by non-adherent cells and a sustained (3 - 120 min) phase mediated by CD11b/CD18 adherent eosinophils. Studies were undertaken to compare the int...

journal_title：British journal of pharmacology

authors： Lynch OT,Giembycz MA,Barnes PJ,Lindsay MA

更新日期：2001-10-01 00:00:00

abstract：:1 The effects of a subconstrictor dose of histamine (9 x 10(-7) mol/l) on the responses of the isolated perfused ear artery of the rabbit to electrical stimulation (E.S.) and to exogenous noradrenaline (NA) were investigated.2 Both intraluminal (I/L) and extraluminal (E/L) histamine potentiated responses to E.S. and t...

journal_title：British journal of pharmacology

authors： Foldes A,Hall RC

更新日期：1979-11-01 00:00:00

abstract：:1 Groups of mice were pretreated with the 5-hydroxytryptamine (5-HT) depletors, fenfluramine or p-chlorophenylalanine (PCPA), followed by pethidine or morphine. 2 Fenfluramine alone produced a short lasting analgesia but PCPA was without any effect. 3 Pethidine and morphine both increased hot plate reaction times meas...

journal_title：British journal of pharmacology

authors： Botting R,Morinan A

更新日期：1982-04-01 00:00:00

abstract：:1. Treatment of rat mesangial cells with interleukin 1 beta (IL-1 beta) or tumour necrosis factor alpha (TNF alpha) has been shown to induce a macrophage-type of nitric oxide (NO) synthase. Here we report that adenosine 3':5'-cyclic monophosphate (cyclic AMP) is another mediator that triggers induction of NO synthase ...

journal_title：British journal of pharmacology

authors： Mühl H,Kunz D,Pfeilschifter J

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Avarol is a marine sesquiterpenoid hydroquinone with anti-inflammatory and antipsoriatic properties. The aim of this study was to evaluate the in vitro and in vivo pharmacological behaviour of the derivative avarol-3'-thiosalicylate (TA) on some inflammatory parameters related to the pathogenesis...

journal_title：British journal of pharmacology

authors： Amigó M,Payá M,De Rosa S,Terencio MC

更新日期：2007-10-01 00:00:00

abstract：:1. The mechanism of the inhibitory effect of dehydroemetine on the heart was investigated using (a) the spontaneously contracting isolated guinea-pig atrial preparation and (b), the electrically driven left atrial preparation.2. Dehydroemetine decreased the rate and amplitude of contraction of spontaneously contractin...

journal_title：British journal of pharmacology

authors： Salako LA

更新日期：1972-12-01 00:00:00

abstract：:The pharmacological properties of fatty acid amidohydrolase (FAAH) were investigated in brains of 35-day-old chickens, since nothing is known about the enzyme in avian species. FAAH activity towards both [(3)H]-palmitoylethanolamide (PEA) [K(M)=1.5 microM] and [(3)H]-anandamide (AEA) [K(M)=5.4 microM] was demonstrated...

journal_title：British journal of pharmacology

authors： Fowler CJ,Börjesson M,Tiger G

更新日期：2000-10-01 00:00:00

abstract：:1. Leptin, a pleiotropic hormone believed to regulate body weight, has recently been associated with inflammatory states and immune activity. Here we have studied the effect of leptin on expression of IFN-gamma-induced nitric oxide synthase (iNOS) and cyclo-oxygenase-2 (COX-2), both prominent markers of macrophage act...

journal_title：British journal of pharmacology

authors： Raso GM,Pacilio M,Esposito E,Coppola A,Di Carlo R,Meli R

更新日期：2002-11-01 00:00:00

abstract：:1. The bovine pulmonary vein contracts in response to acetylcholine, histamine, 5-hydroxytryptamine and bradykinin. The tissue is particularly sensitive to 5-hydroxytryptamine (>0.1 ng/ml). Specific Schultz-Dale reactions were elicited in the pulmonary vein in response to horse plasma.2. The Schultz-Dale reaction is i...

journal_title：British journal of pharmacology

authors： Eyre P

更新日期：1971-10-01 00:00:00

abstract：:1 Anthopleurin-B (AP-B, greater than 3 x 10(-9) M), a newly isolated polypeptide from sea anemone (Anthopleura xanthogrammica), caused powerful rhythmic contractions in the guinea-pig isolated vas deferens. The other polypeptides anthopleurin-A from A. xanthogrammica and anthopleurin-C from A. elegantissima, elicited ...

journal_title：British journal of pharmacology

authors： Norton TR,Ohizumi Y,Shibata S

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:3,4-Methylenedioxymethamphetamine (MDMA or 'Ecstasy') is a worldwide major drug of abuse known to elicit neurotoxic effects. The mechanisms underlying the neurotoxic effects of MDMA are not clear at present, but the metabolism of dopamine and 5-HT by monoamine oxidase (MAO), as well as the hepati...

journal_title：British journal of pharmacology

authors： Barbosa DJ,Capela JP,Oliveira JM,Silva R,Ferreira LM,Siopa F,Branco PS,Fernandes E,Duarte JA,de Lourdes Bastos M,Carvalho F

更新日期：2012-02-01 00:00:00

abstract：:The effect of the selective serotonin reuptake inhibitor fluoxetine was examined on the 5-HT4 receptor-mediated relaxation in the rat isolated ileum. Fluoxetine unsurmountably antagonized the relaxation to exogenous 5-HT with abolition of the response at 10 microM. Fluoxetine (10 microM) also caused a gradual loss of ...

journal_title：British journal of pharmacology

authors： Tuladhar BR,Costall B,Naylor RJ

更新日期：2002-05-01 00:00:00

abstract：:1. We investigated the nitric oxide (NO) dependence of vasorelaxation in response to different calcium channel blockers (CCB), in rabbit femoral artery in vivo. 2. Anaesthetized rabbits underwent femoral artery ligation, and blood from the proximal artery was returned distal to the ligature through a constant infusion...

journal_title：British journal of pharmacology

authors： Xu B,Xiao-hong L,Lin G,Queen L,Ferro A

更新日期：2002-06-01 00:00:00

abstract：:1. The possible involvement of nitric oxide (NO) in the induction and expression of morphine tolerance and dependence was studied in mice. A two-day repeated injection regimen was used to induce morphine tolerance and dependence. Tolerance was assessed by the tail flick test and physical dependence by naloxone challen...

journal_title：British journal of pharmacology

authors： Dambisya YM,Lee TL

更新日期：1996-03-01 00:00:00

abstract：:1. Changes in cutaneous water loss were followed by continuously monitoring total body weight loss.2. Sweating was induced in normal subjects by raising the environmental temperature or by subjecting them to the emotional stress of mental arithmetic.3. Propranolol in a dosage of 0.15 mg/kg body weight intravenously ha...

journal_title：British journal of pharmacology

authors： Allen JA,Jenkinson DJ,Roddie IC

更新日期：1973-03-01 00:00:00

abstract：:1. Our study was aimed at investigating the duration of the bronchodilator action of the antimuscarinc drug glycopyrrolate compared to tiotropium and ipratropium. In the guinea-pig isolated trachea, the time (t1/2) necessary for a contractile response to carbachol (0.3 microM) to return to 50% recovery after washout o...

journal_title：British journal of pharmacology

authors： Villetti G,Bergamaschi M,Bassani F,Bolzoni PT,Harrison S,Gigli PM,Janni A,Geppetti P,Civelli M,Patacchini R

更新日期：2006-06-01 00:00:00

abstract：:1. Two preparations, a segment of the ileum and the myenteric plexuslongitudinal muscle preparation, have been used for an analysis of the inhibitory effects of adrenaline, noradrenaline and isoprenaline on the contractor responses of the longitudinal muscle to acetylcholine or to electrical, coaxial or field, stimula...

journal_title：British journal of pharmacology

authors： Kosterlitz HW,Lydon RJ,Watt AJ

更新日期：1970-06-01 00:00:00