Differences in the pharmacological properties of rat and chicken brain fatty acid amidohydrolase.

abstract：:1. The aim of the study was to compare the effects of 14 day subcutaneous infusion of the 5-HT(2C) receptor agonists, m-chlorophenylpiperazine (mCPP, 12 mg kg(-1) day(-1)) and Ro 60-0175 (36 mg kg(-1) day(-1)) and the 5-HT releasing agent and re-uptake inhibitor, d-fenfluramine (6 mg kg(-1) day(-1)), on food and water...

journal_title：British journal of pharmacology

authors： Vickers SP,Benwell KR,Porter RH,Bickerdike MJ,Kennett GA,Dourish CT

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Diabetes is a risk factor for the development of coronary artery disease but it is not known whether the functions of endothelium-derived nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) in coronary arteries are altered in the early stage of diabetes. Such alterations and t...

journal_title：British journal of pharmacology

authors： Kajikuri J,Watanabe Y,Ito Y,Ito R,Yamamoto T,Itoh T

更新日期：2009-09-01 00:00:00

abstract：:In the present study we tested the effects of the antihyperalgesic compound gabapentin on dorsal horn neurones in adult spinal cord. Slices were taken from control and hyperalgesic animals suffering from streptozocin-induced diabetic neuropathy. At concentrations up to 100 microM, bath application failed to affect the...

journal_title：British journal of pharmacology

authors： Patel MK,Gonzalez MI,Bramwell S,Pinnock RD,Lee K

更新日期：2000-08-01 00:00:00

abstract：:1. Effects of morphine sulphate (1.25, 2.5, 5, 10, 20 and 40 mg/kg i.p.) on locomotor activity of male rats were observed for 8 h after single doses in non-tolerant rats. The lower three doses had only an excitatory effect, whereas the higher three doses caused initial depression followed by a delayed excitatory effec...

journal_title：British journal of pharmacology

authors： Babbini M,Davis WM

更新日期：1972-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inhibitors of phosphodiesterase 5 (PDE5) affect signalling pathways by elevating cGMP, which is a second messenger involved in processes of neuroplasticity. In the present study, the effects of the PDE5 inhibitor, sildenafil, on the pathological features of Alzheimer's disease and on memory-relat...

journal_title：British journal of pharmacology

authors： Cuadrado-Tejedor M,Hervias I,Ricobaraza A,Puerta E,Pérez-Roldán JM,García-Barroso C,Franco R,Aguirre N,García-Osta A

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cannabis extracts and several cannabinoids have been shown to exert broad anti-inflammatory activities in experimental models of inflammatory CNS degenerative diseases. Clinical use of many cannabinoids is limited by their psychotropic effects. However, phytocannabinoids like cannabidiol (CBD), d...

journal_title：British journal of pharmacology

authors： Kozela E,Lev N,Kaushansky N,Eilam R,Rimmerman N,Levy R,Ben-Nun A,Juknat A,Vogel Z

更新日期：2011-08-01 00:00:00

abstract：:1. LP-805, 8-tert-butyl-6,7-dihydropyrrolo-[3,2-e]-5-methylpyrazolo- [1,5a]-pyrimidine-3-carbonitrile, is a newly synthesized potent vasodilator. To investigate the cellular mechanisms of vasorelaxation induced by LP-805, we simultaneously determined the effects of LP-805 on cytosolic Ca2+ concentrations ([Ca2+]i) and...

journal_title：British journal of pharmacology

authors： Ushio-Fukai M,Hirano K,Kanaide H

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Translation of non-clinical markers of delayed ventricular repolarization to clinical prolongation of the QT interval corrected for heart rate (QTc) (a biomarker for torsades de pointes proarrhythmia) remains an issue in drug discovery and regulatory evaluations. We retrospectively analysed 150 d...

journal_title：British journal of pharmacology

authors： Park E,Gintant GA,Bi D,Kozeli D,Pettit SD,Pierson JB,Skinner M,Willard J,Wisialowski T,Koerner J,Valentin JP

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cholecystokinin (CCK) is secreted by intestinal I cells and regulates important metabolic functions. In pancreatic islets, CCK controls beta cell functions primarily through CCK1 receptors, but the signalling pathways downstream of these receptors in pancreatic beta cells are not well defined. E...

journal_title：British journal of pharmacology

authors： Ning SL,Zheng WS,Su J,Liang N,Li H,Zhang DL,Liu CH,Dong JH,Zhang ZK,Cui M,Hu QX,Chen CC,Liu CH,Wang C,Pang Q,Chen YX,Yu X,Sun JP

更新日期：2015-11-01 00:00:00

abstract：:1. Changes in cutaneous water loss were followed by continuously monitoring total body weight loss.2. Sweating was induced in normal subjects by raising the environmental temperature or by subjecting them to the emotional stress of mental arithmetic.3. Propranolol in a dosage of 0.15 mg/kg body weight intravenously ha...

journal_title：British journal of pharmacology

authors： Allen JA,Jenkinson DJ,Roddie IC

更新日期：1973-03-01 00:00:00

abstract：:1. The effects of ryanodine on changes in cytoplasmic Ca2+ level ([Ca2+]i) and muscle tension induced by maximum concentrations of phenylephrine (Phe; 1 microM), prostaglandin F2 alpha (PGF2 alpha, 10 microM), caffeine (Caf, 30 mM) and isoprenaline (Iso, 1 microM) were examined in rat aortic strips using fura-2. 2. In...

journal_title：British journal of pharmacology

authors： Hisayama T,Takayanagi I,Okamoto Y

更新日期：1990-08-01 00:00:00

abstract：:1. To examine further the potentiation by endothelin-1 on the vascular response to sympathetic stimulation, we studied the isometric response of isolated segments, 2 mm long, from the rabbit central ear artery to electrical field stimulation (1-8 Hz), under different conditions, at 37 degrees C and during cooling (30 ...

journal_title：British journal of pharmacology

authors： García-Villalón AL,Padilla J,Fernández N,Monge L,Gómez B,Diéguez G

更新日期：1997-08-01 00:00:00

abstract：:1. Nitric oxide (NO)-mediated neurotransmission is impaired in anococcygeus muscle from 8-week streptozotocin-induced diabetic rats. This study investigated the effects of insulin treatment, and the duration of diabetes on this impairment. In addition, the effect of in vitro exposure to elevated glucose has been inves...

journal_title：British journal of pharmacology

authors： Way KJ,Reid JJ

更新日期：1995-06-01 00:00:00

abstract：:The effects of several anticonvulsant drugs on sodium-dependent high affinity choline uptake (HACU) in mouse hippocampal synaptosomes was investigated. HACU was measured in vitro after in vivo administration of the drug to mice. HACU was inhibited by drugs which have in common the ability to facilitate gamma-aminobuty...

journal_title：British journal of pharmacology

authors： Miller JA,Richter JA

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuropeptides are involved in the regulation of food intake in the central nervous system, but they might also act on peripheral fat tissue via neuropeptide receptors. EXPERIMENTAL APPROACH:We investigated the receptor expression and activity of pituitary adenylate cyclase-activating polypeptide...

journal_title：British journal of pharmacology

authors： Gericke MT,Kosacka J,Koch D,Nowicki M,Schröder T,Ricken AM,Nieber K,Spanel-Borowski K

更新日期：2009-06-01 00:00:00

abstract：:Robert F. Furchgott, pharmacologist and joint winner of the Nobel Prize for Medicine or Physiology (1998) died on the 12th of May 2009 aged 92. By unlocking the astonishingly diverse biological actions of nitric oxide, Furchgott leaves behind a rich legacy that has both revolutionized our understanding of human physio...

journal_title：British journal of pharmacology

authors： Martin W

更新日期：2009-10-01 00:00:00

abstract：:We have studied the effects of the weak bases chloroquine, NH4Cl and amantadine on the handling of certain cardiac glycosides by HeLa cells. When these weak bases are applied acutely to HeLa cells they have only minor effects on the binding of cardiac glycosides to the sodium pumps and on the recovery of pump function...

journal_title：British journal of pharmacology

authors： Griffiths N,Lamb JF,Ogden P

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:8-Nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP), formed nitric oxide (NO)-dependently, is a physiological second messenger, yet little is known about its role in the pathophysiology of vascular diseases. To study the pharmacological activity of 8-nitro-cGMP in diabetic mice, we compare...

journal_title：British journal of pharmacology

authors： Tokutomi Y,Kataoka K,Yamamoto E,Nakamura T,Fukuda M,Nako H,Toyama K,Dong YF,Ahmed KA,Sawa T,Akaike T,Kim-Mitsuyama S

更新日期：2011-04-01 00:00:00

abstract：:By implanting a Teflon chamber subcutaneously into a sheep a mild aseptic inflammatory lesion was produced from which wound fluid could be sampled daily. The prostaglandin content of this wound fluid was examined. Prostaglandin E2 activity was found in all samples, and a peak was apparent on the fourth or fifth day af...

journal_title：British journal of pharmacology

authors： Greenwood B,Kerry PJ

更新日期：1975-02-01 00:00:00

abstract：:1. We aimed to determine whether nitric oxide (NO) and/or the endothelium is involved in cholinergic neurogenic vasodilatation in the rat isolated hindquarters. 2. The abdominal aorta was cannulated for perfusion of the rat hindquarters with Krebs bicarbonate solution containing phenylephrine, to induce basal constric...

journal_title：British journal of pharmacology

authors： Loke KE,Sobey CG,Dusting GJ,Woodman OL

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Combretastatin A-4 3-O-phosphate (CA4P) is in clinical trial as a tumour vascular disrupting agent (VDA) but the cause of blood flow disruption is unclear. We tested the hypothesis that activation of Rho/Rho kinase (ROCK) is fundamental to the effects of this drug in vivo. EXPERIMENTAL APPROACH:...

journal_title：British journal of pharmacology

authors： Williams LJ,Mukherjee D,Fisher M,Reyes-Aldasoro CC,Akerman S,Kanthou C,Tozer GM

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors, and three subtypes (α, β and γ) have been identified. PPAR activation has been reported to decrease renal injury and markers of glomerular dysfunction in models of renal ischemia/reperfusion (I/R). How...

journal_title：British journal of pharmacology

authors： Miglio G,Rosa AC,Rattazzi L,Grange C,Collino M,Camussi G,Fantozzi R

更新日期：2011-01-01 00:00:00

abstract：:1. The aim of this study was to investigate whether the hypotensive effect of rat alpha-calcitonin gene-related peptide (alpha CGRP) in conscious rats is mediated by endothelium-derived nitric oxide (NO) or the opening of adenosine 5'-triphosphate (ATP)-sensitive potassium (KATP) channels. 2. Dose-mean arterial pressu...

journal_title：British journal of pharmacology

authors： Abdelrahman A,Wang YX,Chang SD,Pang CC

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Positive modulators of small conductance Ca(2+)-activated K(+) channels (SK1, SK2, and SK3) exert hyperpolarizing effects that influence the activity of excitable and non-excitable cells. The prototype compound 1-EBIO or the more potent compound NS309, do not distinguish between the SK subtypes a...

journal_title：British journal of pharmacology

authors： Hougaard C,Eriksen BL,Jørgensen S,Johansen TH,Dyhring T,Madsen LS,Strøbaek D,Christophersen P

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In endothelial dysfunction, signalling by nitric oxide (NO) is impaired because of the oxidation and subsequent loss of the soluble guanylyl cyclase (sGC) haem. The sGC activator 4-[((4-carboxybutyl){2-[(4-phenethylbenzyl)oxy]phenethyl}amino)methyl[benzoic]acid (BAY 58-2667) is a haem-mimetic abl...

journal_title：British journal of pharmacology

authors： Hoffmann LS,Schmidt PM,Keim Y,Schaefer S,Schmidt HH,Stasch JP

更新日期：2009-07-01 00:00:00

abstract：:1. Simultaneous computer modelling of control and guanfacine-masked [3H]-MK 912 saturation curves as well as guanfacine competition curves revealed that the drugs bound to two alpha 2-adrenoceptor subtypes in the rat cerebral cortex with very different selectivities. These alpha 2-adrenoceptor subtypes were designated...

journal_title：British journal of pharmacology

authors： Uhlén S,Xia Y,Chhajlani V,Felder CC,Wikberg JE

更新日期：1992-08-01 00:00:00

abstract：:1 Citrated platelet-rich plasma was prepared from New Zealand white rabbits before, during and after administration of chlorpromazine (2 mg/kg) intramuscularly once daily for 3 to 4 weeks. 2 In these plasmas, the velocity of platelet aggregation by 5-hydroxytryptamine (5-HT) added at 1, 3 and 10 microM increased great...

journal_title：British journal of pharmacology

authors： Baldacci M,Baldacci M,Bergel TD,Born GV,Hickman M

更新日期：1980-05-01 00:00:00

abstract：:1. Behavioural activity (delayed differentiation and spatial delayed alternation) and pharmacokinetics of diazepam and its metabolites, N-desmethyldiazepam (nordiazepam), 3-hydroxydiazepam (temazepam) and 3-hydroxy-N-desmethyldiazepam (oxazepam), and of dipotassium clorazepate (clorazepate), were studied in the monkey...

journal_title：British journal of pharmacology

authors： Curry SH,Whelpton R,Nicholson AN,Wright CM

更新日期：1977-11-01 00:00:00

abstract：:Although previous reports have suggested that the sigma 1 (sigma(1)) receptor may be involved in pain sensation, its specific site of action has not been elucidated. The aim of present study was to determine the role of the spinal sigma(1) receptor in formalin-induced pain behavior, spinal cord Fos expression and phos...

journal_title：British journal of pharmacology

authors： Kim HW,Kwon YB,Roh DH,Yoon SY,Han HJ,Kim KW,Beitz AJ,Lee JH

更新日期：2006-06-01 00:00:00

abstract：:1. We have characterized the 5-hydroxytryptamine (5-HT)-induced calcium signalling in endothelial cells from the human pulmonary artery. Using RT-PCR we show, that of all cloned G-protein coupled 5-HT receptors, these cells express only 5-HT1D beta, 5-HT2B and little 5-HT4 receptor mRNA. 2. In endothelial cells 5-HT i...

journal_title：British journal of pharmacology

authors： Ullmer C,Boddeke HG,Schmuck K,Lübbert H

更新日期：1996-03-01 00:00:00