Effect of platelet-rich plasma on bone regeneration in autogenous bone graft.

Abstract:

:In this study, we evaluated the effect of platelet-rich plasma (PRP) on bone regeneration in an autogenous bone graft in a canine model. The mandibular premolar teeth had been bilaterally extracted previously, and the ridges had been allowed to heal for 3 months. After this period, continuity resection was performed on both sides of the mandible. One defect (the PRP group) was reconstructed with the original particulate bone mixed with PRP. As a control, the contralateral defect (non-PRP group) was reconstructed with the original particulate bone alone. Biopsies after 6 weeks showed lower levels of bone formation in the PRP group than in the non-PRP group, and fluorescence microscopy revealed a delay in the remodelling of grafts loaded with PRP. These findings suggest that the addition of PRP does not appear to enhance new bone formation in autogenous bone grafts.

authors

Choi BH,Im CJ,Huh JY,Suh JJ,Lee SH

doi

10.1054/ijom.2003.0466

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

56-9

issue

1

eissn

0901-5027

issn

1399-0020

pii

S0901-5027(03)90466-8

journal_volume

33

pub_type

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