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Thyroid-stimulating hormone receptor and its role in Graves' disease.

Abstract：

:The thyroid-stimulating hormone (TSH, or thyrotropin) receptor (TSHR) mediates the activating action of TSH to the thyroid gland, resulting in the growth and proliferation of thyrocytes and thyroid hormone production. In Graves' disease, thyroid-stimulating autoantibodies can mimic TSH action and stimulate thyroid cells. This leads to hyperthyroidism and abnormal overproduction of thyroid hormone. TSHR-antibodies-binding epitopes on the receptor molecule are well studied. Mechanism of TSHR-autoantibodies production is more or less clear but a susceptibility gene, which is linked to their production, is still unknown. Genetic studies show no linkage between the TSHR gene and Graves' disease. Among three common polymorphisms in the TSHR gene, only the D727E germline polymorphism in the cytoplasmic tail of the receptor showed an association with the disease, and this association is weak. The absence of a strong genetic effect of the TSHR polymorphisms in such a common and complex disorder as Graves' disease may be explained by a high degree of evolutionary conservation in TSHR. This can be shown by naturally existing germline and somatic mutations in the TSHR gene that cause various types of nonautoimmune and hereditary thyroid disease.

journal_name

Mol Genet Metab

journal_title

Molecular genetics and metabolism

authors

Chistiakov DA

doi

10.1016/j.ymgme.2003.09.001

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

377-88

issue

4

eissn

1096-7192

issn

1096-7206

pii

S1096719203001938

journal_volume

80

pub_type

杂志文章,评审

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