Molecular mechanisms of tumor formation.

Abstract:

:DNA is the fundamental guide for the cell's processes. The alterations in DNA that can lead to abnormal or absent proteins and the role of chromosomal alterations in changing the function of the DNA are reviewed. The role of viruses in derailing a cell's normal functions, the major mechanisms of oncogene action, and tumor suppressor genes are also discussed.

journal_name

Am J Surg

authors

Samara G,Hurwitz M,Sawicki M,Passaro E Jr

doi

10.1016/s0002-9610(05)80911-0

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

389-96

issue

4

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(05)80911-0

journal_volume

164

pub_type

杂志文章,评审
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    abstract::Fifty-eight patients with invasive melanoma of the head and neck underwent regional nodal dissections by one surgeon from 1971 to 1981. Types of nodal dissections employed were radical neck dissection and modified radical neck dissection, alone or in combination, with selective nodal dissection of the parotid, jugular...

    journal_title:American journal of surgery

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    doi:10.1016/0002-9610(84)90367-2

    authors: Turkula LD,Woods JE

    更新日期:1984-10-01 00:00:00

  • Skin-sparing mastectomy.

    abstract:BACKGROUND:Skin-sparing mastectomy represents a new surgical approach that allows a mastectomy while preserving the natural skin envelope of the breast. It facilitates immediate breast reconstruction using an implant or myocutaneous flap, resulting in excellent cosmesis. DATA SOURCES:A PubMed database literature searc...

    journal_title:American journal of surgery

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    doi:10.1016/j.amjsurg.2004.02.004

    authors: Cunnick GH,Mokbel K

    更新日期:2004-07-01 00:00:00

  • When surgeons face intraoperative challenges: a naturalistic model of surgical decision making.

    abstract:BACKGROUND:Surgery is an environment in which being an expert requires the ability to manage the unexpected. This feature has necessitated a shift in surgical decision-making research. The present study explores the processes by which surgeons assess and respond to nonroutine challenges in the operating room. METHODS:...

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    doi:10.1016/j.amjsurg.2012.10.005

    authors: Cristancho SM,Vanstone M,Lingard L,LeBel ME,Ott M

    更新日期:2013-02-01 00:00:00

  • Consensus statement on the adoption of the COPE guidelines.

    abstract::We the undersigned editors of the member journals of the Surgery Journal Editors Group (SJEG), in the furtherance of integrity in surgical and scientific publication, agree to adopt the guidelines established by the Committee on Publication Ethics (COPE). The COPE guidelines represent a means of addressing a variety o...

    journal_title:American journal of surgery

    pub_type: 社论

    doi:10.1016/j.amjsurg.2010.06.001

    authors: Surgery Journal Editors Group.

    更新日期:2010-07-01 00:00:00

  • A critical evaluation of the morbidity and mortality conference.

    abstract:BACKGROUND:This study was designed to evaluate the impact of changes made to our morbidity and mortality (M&M) conference. METHODS:A 23-item survey using corresponding Likert-type scales was created. Faculty and residents were asked to anonymously complete the surveys in June 1999. Based on this information, specific ...

    journal_title:American journal of surgery

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    doi:10.1016/s0002-9610(02)00791-2

    authors: Murayama KM,Derossis AM,DaRosa DA,Sherman HB,Fryer JP

    更新日期:2002-03-01 00:00:00

  • Incidence of overall complications and symptomatic tracheal stenosis is equivalent following open and percutaneous tracheostomy in the trauma patient.

    abstract:BACKGROUND:While percutaneous tracheostomy (PT) is becoming the procedure of choice for elective tracheostomy, there is little late complication data. This study compared incidence of, and factors contributing to, tracheal stenosis following PT or open tracheostomy (OT). METHODS:A 10-year review was conducted of traum...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2013.12.036

    authors: Kettunen WW,Helmer SD,Haan JM

    更新日期:2014-11-01 00:00:00

  • The consequences of current constraints on surgical treatment of appendicitis.

    abstract::In this study, we sought to identify changes in the picture of a selected surgical condition during an interval of time that has brought about radical departures from previously established policies and programs. As a direct consequence, the patients take a more circuitous route to the surgeon. A significant number of...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(89)90549-7

    authors: Cacioppo JC,Diettrich NA,Kaplan G,Nora PF

    更新日期:1989-03-01 00:00:00

  • Adrenocorticotropic hormone and cortisol response to corticotropin releasing hormone in the critically ill-a novel assessment of the hypothalamic-pituitary-adrenal axis.

    abstract:BACKGROUND:The pathophysiology of adrenal insufficiency, common in surgical intensive care units, has not been fully elucidated. METHODS:Patients at risk (age > 55 years, in the surgical intensive care unit >1 week, baseline cortisol < 20 μg/dL) were enrolled. After measuring cortisol and adrenocorticotropic hormone (...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2010.11.015

    authors: Schuster KM,Macleod JB,Fernandez JB,Kumar M,Barquist ES

    更新日期:2012-02-01 00:00:00

  • Adjuvant chemotherapy in advanced head and neck cancer. An update.

    abstract::Two courses of triple-agent chemotherapy were given to 47 patients with advanced head and neck cancer. All but one patient with a nasopharyngeal carcinoma had resectable stage III and IV squamous cell carcinoma. Eighty-eight percent of the patients responded to the chemotherapy with a 50 percent or greater decrease in...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(82)90417-2

    authors: Spaulding MB,Kahn A,De Los Santos R,Klotch D,Loré JM Jr

    更新日期:1982-10-01 00:00:00

  • The emergency surgical airway: Bridging the gap from quality outcome to performance improvement through a novel simulation based curriculum.

    abstract:BACKGROUND:Emergency surgical airway is a low frequency, high risk clinical scenario. Implementing a simulation-based curriculum may bridge the gap in surgical training and address quality assurance/performance improvement (QAPI) needs. METHODS:We designed and implemented an Advanced Surgical Airway Curriculum (ASAC) ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2018.09.026

    authors: Veenstra BR,Wojtowicz A,Walsh N,Velasco JM

    更新日期:2019-03-01 00:00:00

  • Current perspectives on antibiotic use in the treatment of surgical infections.

    abstract::Infections that involve the attention of the surgeon include those that require operations for cure as well as those that complicate emergency and elective surgical procedures. Mechanical correction is of paramount importance in the eradication of such infections with antibiotics serving an adjuvant role, primarily to...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(06)80057-7

    authors: Cheadle WG

    更新日期:1992-10-01 00:00:00

  • Aggressive metastasectomy for pulmonic sarcomatous metastases: a follow-up study.

    abstract::Pulmonary metastases are the primary cause of death due to bone and soft tissue sarcomas. We have previously shown that an aggressive approach and a new technique of multiple pulmonary metastasectomies have resulted in improved survival for patients with pulmonary metastases. In this follow-up study, an expanded datab...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(05)81150-x

    authors: Saltzman DA,Snyder CL,Ferrell KL,Thompson RC,Leonard AS

    更新日期:1993-11-01 00:00:00

  • A comparison of postoperative outcomes utilizing a continuous preperitoneal infusion versus epidural for midline laparotomy.

    abstract:BACKGROUND:Postoperative pain management with a continuous preperitoneal infusion (CPI) for locoregional anesthesia has been shown to have improved postoperative outcomes. This is the first direct comparison of CPI versus epidural infusion (EPI), both in conjunction with systemic analgesia. METHODS:A retrospective rev...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2011.05.016

    authors: Gross ME,Nelson ET,Mone MC,Hansen HJ,Sklow B,Glasgow RE,Scaife CL

    更新日期:2011-12-01 00:00:00

  • Outcomes and complications after splenectomy for hematologic disorders.

    abstract:BACKGROUND:Splenectomy is generally a second-line therapy in patients with immune thrombocytopenic purpura (ITP) and autoimmune hemolytic anemia (AHA) refractory to medical therapy. Our objective was to evaluate outcomes after splenectomy for these disorders. METHODS:A retrospective review of the medical records of pa...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2012.05.030

    authors: Patel NY,Chilsen AM,Mathiason MA,Kallies KJ,Bottner WA

    更新日期:2012-12-01 00:00:00

  • Staged management of the open abdomen and enteroatmospheric fistulae using split-thickness skin grafts.

    abstract:BACKGROUND:Management of the open abdomen with polyglactin 910 mesh followed by split-thickness skin grafts allows safe, early closure of abdominal wounds. This technique can be modified to manage enteroatmospheric fistulae. Staged ventral hernia is performed in a less inflamed surgical field. METHODS:A retrospective ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2013.07.040

    authors: Cheesborough JE,Park E,Souza JM,Dumanian GA

    更新日期:2014-04-01 00:00:00

  • Drug therapy for inflammatory bowel disease: Part II.

    abstract::Part II of this two-part article (See The American Journal of Surgery 1992; 164: 85-9) reviews the current definition of the role of immunosuppressive therapy in inflammatory bowel disease (IBD) and the use of antibiotics in IBD, as well as summarizes the uses of the new agents on the horizon for the treatment of IBD....

    journal_title:American journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1016/s0002-9610(05)80381-2

    authors: Linn FV,Peppercorn MA

    更新日期:1992-08-01 00:00:00

  • Techniques of parathyroid exploration at North American endocrine surgery fellowship programs: what the next generation is being taught.

    abstract:BACKGROUND:Minimally invasive techniques are now often used to treat primary hyperparathyroidism but with uncertain conformity and some controversy. Endocrine surgery fellowships (ESFPs) have recently proliferated. METHODS:The directors of the 19 ESFPs recognized by the American Association of Endocrine Surgeons were ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2013.05.012

    authors: Wang TS,Pasieka JL,Carty SE

    更新日期:2014-04-01 00:00:00

  • Is thyroid frozen section too much for too little?

    abstract:BACKGROUND:The role of frozen section (FS) in thyroid disease is controversial. The goal of this study was to identify a cohort of patients who may or may not benefit from FS. METHODS:Two hundred thirty-one patients who underwent thyroidectomy were evaluated in regard to fine-needle aspiration (FNA), FS, and the exten...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(02)01074-7

    authors: Richards ML,Chisholm R,Bruder JM,Strodel WE

    更新日期:2002-12-01 00:00:00

  • Can biliary-cyst communication be predicted before surgery for hepatic hydatid disease: does size matter?

    abstract:BACKGROUND:The aim of this study was to determine if there is any predictive factor indicating the risk of bile leakage before surgery for hepatic hydatid disease in clinically asymptomatic patients. METHODS:The data of 116 patients who underwent surgery for hepatic hydatid disease were reviewed retrospectively. There...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2007.07.034

    authors: Kilic M,Yoldas O,Koc M,Keskek M,Karakose N,Ertan T,Gocmen E,Tez M

    更新日期:2008-11-01 00:00:00

  • Intraoperative nerve monitoring is associated with a lower risk of recurrent laryngeal nerve injury: A national analysis of 17,610 patients.

    abstract:BACKGROUND:Based on current evidence, the benefit of intraoperative nerve monitoring (IONM) in thyroid surgery is equivocal. METHODS:All patients who underwent planned thyroid surgery in the 2016-2018 ACS NSQIP procedure-targeted thyroidectomy dataset were included. Multivariable regression analyses were performed to ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2020.10.013

    authors: Kim J,Graves CE,Jin C,Duh QY,Gosnell JE,Shen WT,Suh I,Sosa JA,Roman SA

    更新日期:2020-10-16 00:00:00

  • Intestinal glutamine metabolism after massive small bowel resection.

    abstract::Gut glutamine utilization after massive small bowel resection was studied to gain further insight into the alterations and adaptations in intestinal glutamine metabolism that occur during the development of post-resectional hyperplasia. After resection of the middle 60% of the small intestine in the rat, gut glutamine...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(05)80603-8

    authors: Klimberg VS,Souba WW,Salloum RM,Holley DT,Hautamaki RD,Dolson DJ,Copeland EM 3rd

    更新日期:1990-01-01 00:00:00

  • Surgical treatment of esophageal carcinoma.

    abstract::Recent progress in the surgical treatment of carcinoma of the esophagus has changed the pessimistic outlook for this malignancy. With reasonably early diagnosis, it is feasible to achieve a resectability rate of 75 to 85 percent, an operative mortality of about 5 percent and a 5 year survival rate of about 30 percent....

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(80)90386-4

    authors: Wu YK,Chen PT,Fang JP,Lin SS

    更新日期:1980-06-01 00:00:00

  • The relationship between faculty ward evaluations, OSCE, and ABSITE as measures of surgical intern performance.

    abstract:BACKGROUND:This study determined the degree to which ward evaluations, the American Board of Surgery In-Training Examination (ABSITE), and an Objective Structured Clinical Examination (OSCE) provide equivalent information about intern performance. METHODS:Twenty-two general surgery interns completed both the ABSITE an...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(99)80187-1

    authors: Schwartz RW,Donnelly MB,Sloan DA,Johnson SB,Strodel WE

    更新日期:1995-04-01 00:00:00

  • Controversies in the management of pancreatic pseudocysts.

    abstract::Review of the diagnosis and treatment of patients with pancreatic pseudocysts over the past 8 years has led us to three conclusions regarding controversial aspects of their treatment. We found that patients who present with chronic pseudocysts can be identified with the help of computerized axial tomography and prompt...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(88)80275-7

    authors: Mullins RJ,Malangoni MA,Bergamini TM,Casey JM,Richardson JD

    更新日期:1988-01-01 00:00:00

  • Applying international organization for standards 9001 to create an effective surgical quality committee.

    abstract:BACKGROUND:Efforts to improve surgical safety are limited by several factors and no consensus exists regarding the most effective way to improve surgical quality. The use of ISO 9001 quality standards within healthcare is recognized but has not been widely applied for improving surgical outcomes. METHODS:A surgical qu...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2020.11.014

    authors: Slakey DP,George JS,Anderson E,Willeumier D,Guglielmi K

    更新日期:2020-11-09 00:00:00

  • Use of the stapler in skin closure.

    abstract::The AutoSuture skin stapling instrument reduces operating room time and provides adequate skin closure for a wide variety of plastic surgical procedures. ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(76)90312-3

    authors: Thompson DP,Ashley FL

    更新日期:1976-07-01 00:00:00

  • Verrucous carcinoma, then and now.

    abstract::The salient clinical and pathological features of verrucous carcinoma, as first described by Ackerman in 1948, are reviewed. Two case reports are presented. The first concerns a personal experience with a patient who had five surgical procedures for multifocal oral verrucous carcinoma and remains alive and well 28 yea...

    journal_title:American journal of surgery

    pub_type: 传,历史文章,杂志文章

    doi:10.1016/s0002-9610(98)00232-3

    authors: Spiro RH

    更新日期:1998-11-01 00:00:00

  • Pitfalls in the management of penetrating chest trauma.

    abstract::A prospective study designed specifically to analyze errors in management and iatrogenic complications was conducted on 234 consecutive patients with penetrating chest trauma. Eleven percent of penetrating pleural injuries were incorrectly diagnosed on initial physical and radiologic examination, but this led to wrong...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(89)90577-1

    authors: Hirshberg A,Thomson SR,Bade PG,Huizinga WK

    更新日期:1989-04-01 00:00:00

  • Post-discharge surgical site infection surveillance in a hospital in Brazil.

    abstract::The current study suggests the need for routine post-discharge surveillance to improve reliability on surgical site infection incidence rates. Surveillance only during hospitalization may not provide precise data on the incidence of surgical site infection, underestimating a true postoperative infection rate. ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2006.05.016

    authors: Oliveira AC,Lima ED,Lima Ade P

    更新日期:2007-02-01 00:00:00

  • Role of emergency thoracotomy in the resuscitation of moribund trauma victims: 100 consecutive cases.

    abstract::(1) Emergency thoracotomy can be a lifesaving procedure in critically injured patients who present with no detectable pulse or blood pressure. (2) Emergency thoracotomy is nonproductive if cardiac electrical activity is absent. (3) Best results are achieved in patients with chest injuries and the worst results in thos...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(81)80034-7

    authors: Harnar TJ,Oreskovich MR,Copass MK,Heimbach DM,Herman CM,Carrico CJ

    更新日期:1981-07-01 00:00:00