Abstract：
:Gut glutamine utilization after massive small bowel resection was studied to gain further insight into the alterations and adaptations in intestinal glutamine metabolism that occur during the development of post-resectional hyperplasia. After resection of the middle 60% of the small intestine in the rat, gut glutamine metabolism was studied immediately and 1, 2, and 3 weeks later. Whole gut glutamine extraction was 22% in sham controls and it acutely declined to 12% (p less than 0.01) after bowel resection. Extraction increased to 31% 1 week later (p less than 0.05) and then returned to normal by week 2. Gut ammonia release decreased after massive small bowel resection, whereas intestinal alanine release increased. The increase in gut glutamine extraction at 1 week occurred at a time when jejunal and ileal DNA and protein content were markedly increased (p less than 0.01). Intestinal glutaminase content declined initially and then increased by the third week after bowel resection (p less than 0.01). With time, increases in gut cellularity and glutaminase content are associated with gut glutamine utilization in the shortened small bowel that is equal to that of the intact unresected intestine.
journal_name
Am J Surgjournal_title
American journal of surgeryauthors
Klimberg VS,Souba WW,Salloum RM,Holley DT,Hautamaki RD,Dolson DJ,Copeland EM 3rddoi
10.1016/s0002-9610(05)80603-8subject
Has Abstractpub_date
1990-01-01 00:00:00pages
27-32; discussion 32-3issue
1eissn
0002-9610issn
1879-1883pii
S0002-9610(05)80603-8journal_volume
159pub_type
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