Abstract:
:Glycerol enhances pulmonary tumorigenesis in mice treated with 4-nitroquinoline 1-oxide (4NQO). The present study shows that active oxygen formation by glycerol may be responsible for this enhanced tumorigenesis. Male ddY mice were treated with 4NQO and given a 5% glycerol solution instead of drinking water for up to 4 weeks after 4NQO injection. There was no difference in NADH-dependent active oxygen formation of the mitochondria between the 4NQO- and 4NQO-plus-glycerol-treated groups but the ratios of NADH- and NADPH-dependent active oxygen formation of the microsomes and nuclei of the 4NQO-plus-glycerol-treated group to the 4NQO-treated group increased with increasing time after 4NQO injection. Significant differences in the maximum NADH- and NADPH-dependent active oxygen formation were observed 2 or 4 weeks after 4NQO injection.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Yano T,Ichikawa Tdoi
10.1016/0006-2952(92)90156-dsubject
Has Abstractpub_date
1992-06-23 00:00:00pages
2658-60issue
12eissn
0006-2952issn
1873-2968pii
0006-2952(92)90156-Djournal_volume
43pub_type
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