Abstract:
BACKGROUND:For patients with a diagnosis of vascular dementia there is evidence that aspirin is widely prescribed - in one study, completed by geriatricians and psychiatrists in the UK, 80% of patients with cognitive impairment (with vascular risk factors) were prescribed aspirin. However, a number of queries remain unanswered: Is there convincing evidence that aspirin benefits patients with vascular dementia? Does aspirin affect cognition or improve prognosis? In addition, does the risk of cerebral or gastric haemorrhage outweigh any benefit? OBJECTIVES:To assess the evidence of effectiveness of the use of aspirin for vascular dementia. SEARCH STRATEGY:Computerized databases were searched independently by two reviewers. In addition, relevant websites were searched and some journals were handsearched. Specialists in the field were approached for unpublished material and any publications found were searched for additional references. The most recent search for trials was carried out in February 2000. SELECTION CRITERIA:All randomized controlled trials investigating the effect of aspirin for vascular dementia are included. Inclusion/exclusion of studies comprised systematic assessment of the quality of study design and the risk of bias. DATA COLLECTION AND ANALYSIS:Data were extracted independently by both reviewers, using a previously tested data extraction form and, where required, authors were contacted for data not provided in the papers. The aim is to evaluate data recorded via tools assessing cognitive and behavioural changes along with mortality, morbidity and institutionalization data. MAIN RESULTS:No trials are eligible for inclusion in this review. REVIEWER'S CONCLUSIONS:There is no evidence that aspirin is effective in treating patients with a diagnosis of vascular dementia. Further research is needed to assess the effect of aspirin on cognition, and on other outcomes such as behaviour, and quality of life. At present there is no evidence relating to other queries about the use of aspirin for dementia (these are described in the Background section of this review). The most recent search for references to relevant research was carried out in February 2000, but no new evidence was found.
journal_name
Cochrane Database Syst Revjournal_title
The Cochrane database of systematic reviewsauthors
Williams PS,Rands G,Orrel M,Spector Adoi
10.1002/14651858.CD001296keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
CD001296issue
4issn
1469-493Xpii
CD001296pub_type
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doi:10.1002/14651858.CD002008.pub3
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abstract:BACKGROUND:Chinese herbal medicines are commonly used to treat sore throat in China and are used worldwide by practitioners of traditional Chinese medicine (TCM). Their efficacy in treating sore throat has not previously been systematically reviewed. OBJECTIVES:To assess the efficacy and safety of Chinese herbal medic...
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pub_type: 杂志文章,meta分析,评审
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doi:10.1002/14651858.CD001392.pub3
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pub_type: 杂志文章,meta分析
doi:10.1002/14651858.CD006304.pub4
更新日期:2020-10-09 00:00:00
abstract:BACKGROUND:Simulation-based obstetric team training focuses on building a system that will anticipate errors, improve patient outcomes and the performance of clinical care teams. Simulation-based obstetric team training has been proposed as a tool to improve the overall outcome of obstetric health care. OBJECTIVES:To ...
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doi:10.1002/14651858.CD011545.pub2
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pub_type: 杂志文章,meta分析,评审
doi:10.1002/14651858.CD001297
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