[Streptococcus pyogenes and the brain: living with the enemy].

Abstract:

:Streptococcus pyogenes (or group A beta hemolytic streptococcus) is a pathogenic bacterium that can give rise to a range of invasive and autoimmune diseases, although it is more widely known as the cause of tonsillitis. It is particularly interesting to note that this germ only causes disease in humans. For many years it has been acknowledged that it can cause an autoimmune brain disease (Sydenham s chorea). Yet, the spectrum of post streptococcal brain disorders has recently been extended to include other movement disorders such as tics or dystonia. A number of systematic psychiatric studies have shown that certain emotional disorders generally accompany the movement disorder (particularly, obsessive compulsive disorder). The proposed pathogenetic mechanism is that of a neuronal dysfunction in which antibodies play a mediating role. The antibodies that are produced after the streptococcal infection cross react with neuronal proteins, and more especially so in individuals with a propensity. This represents a possible model of immunological mimicry and its potential importance with respect to certain idiopathic disorders such as Tourette syndrome and obsessive compulsive disorder.

journal_name

Rev Neurol

journal_title

Revista de neurologia

authors

Dale RC

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

92-7

issue

1

eissn

0210-0010

issn

1576-6578

pii

rn2003209

journal_volume

37

pub_type

杂志文章,评审
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  • [Stroke therapy in children].

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    doi:

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    authors: Nácher V

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    authors: Carratalá F,Moya M

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    abstract:INTRODUCTION:The possibility of diagnosing carotid stenosis and carrying out surgery without arteriography has increased with the use of different diagnostic methods. The eco-Doppler has been shown to be a useful method, although it requires previous individualised validation. OBJECTIVE:We aim to validate our Vascular...

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  • [Memory evaluation using functional magnetic resonance: applications in preoperative patients and in Alzheimer s disease].

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  • [The application of telemedicine for stroke in the Balearic Islands: the Balearic Telestroke project].

    abstract:INTRODUCTION:Currently, clinical benefits of stroke units and thrombolysis in ischaemic stroke are evidence-based. However, inequities in coverage and in treatment provided to these patients still persist due to geographical differences in residence, technological capacity and organization among health care systems. Te...

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