Abstract:
:Animal models have been used to simulate the effects of human head trauma. Some of these models have been further utilized to explore how trauma affects specific mechanisms of synaptic plasticity, a cellular model for memory consolidation. Unfortunately, these studies have been more limited in number in spite of their importance for understanding alterations in synaptic plasticity and memory impairments in trauma patients. Research in this area includes well characterized trauma models, genetically engineered animals and neuroprotective studies. One largely ignored but important idea that is entertained here is that trauma may be a crucial aetiological factor for the loss of potassium homeostasis. Moreover, high extracellular potassium has been shown to promote abnormal expression of hippocampal synaptic plasticity due to K(+)-induced glutamate release, thus showing important relationships among trauma, glia, potassium and synaptic plasticity. Collectively, this mini review surveys investigations of head trauma involving altered mechanisms of synaptic plasticity and how trauma may be related to increased risk for dementia.
journal_name
Brain Injjournal_title
Brain injuryauthors
Albensi BC,Janigro Ddoi
10.1080/0269905031000107142subject
Has Abstractpub_date
2003-08-01 00:00:00pages
653-63issue
8eissn
0269-9052issn
1362-301Xpii
956WTE7Q3VL4GUGVjournal_volume
17pub_type
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