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Gene delivery into prostate cancer cells by holmium laser application.

Abstract：

:New approaches to treat prostate cancer (PCA) are utilizing gene therapy and aim to correct the disease at the genetic level. Getting a gene efficiently into the target cell is the subject of much interest. We used a holmium laser for transfecting rat PCA cells with the reporter gene pEGFP. By FACS analysis and fluorescence microscopy, we could demonstrate that cellular delivery of plasmid DNA was possible with high efficiencies up to 41.3%. Therefore, transfection of PCA cells by holmium laser might offer a promising new gene transfer strategy to PCA with minimal invasiveness.

journal_name

Prostate Cancer Prostatic Dis

journal_title

Prostate cancer and prostatic diseases

authors

Sagi S,Knoll T,Trojan L,Schaaf A,Alken P,Michel MS

doi

10.1038/sj.pcan.4500653

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

127-30

issue

2

eissn

1365-7852

issn

1476-5608

pii

4500653

journal_volume

6

pub_type

杂志文章

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