Predicting neuropsychologic outcome after traumatic brain injury in children.

Abstract:

:The ability to predict long-term neurologic and neuropsychologic outcomes in 22 children, ages 1 week to 14 years at the time of traumatic brain injury, was investigated using proton magnetic resonance spectroscopy acquired post injury and compared with standardized neurologic, intellectual, and neuropsychologic testing done 1-7 years later. Clinical indicators of acute injury severity including age at injury, electroencephalography, spectroscopy metabolite ratio variables (N-acetyl aspartate/choline, choline/creatine) and lactate presence accurately classified children as functioning above or below the average range for most intellectual and neuropsychologic outcome measures. Combined clinical and spectroscopy variables accounted for approximately 50% of the variance in cognitive and neuropsychologic outcome confirming the validity of their predictive use. Of the injury severity indictors, presence of lactate is a particularly important prognostic marker of poor long-term intellectual and neuropsychologic functioning. Our findings indicate the potential for providing accurate estimates of long-term intellectual and neuropsychologic function after traumatic brain injury in infants and children using proton magnetic resonance spectroscopy in combination with clinical variables.

journal_name

Pediatr Neurol

journal_title

Pediatric neurology

authors

Brenner T,Freier MC,Holshouser BA,Burley T,Ashwal S

doi

10.1016/s0887-8994(02)00491-5

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

104-14

issue

2

eissn

0887-8994

issn

1873-5150

pii

S0887899402004915

journal_volume

28

pub_type

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