Biodegradable nanoparticles for drug and gene delivery to cells and tissue.

abstract：:Silicon is one of the most abundant chemical elements found on the Earth. Due to its unique chemical and physical properties, silicon based materials and their oxides (e.g. silica) have been used in several industries such as building and construction, electronics, food industry, consumer products and biomedical engin...

journal_title：Advanced drug delivery reviews

authors： Jaganathan H,Godin B

更新日期：2012-12-01 00:00:00

abstract：:The mammalian immune system has evolved mechanisms to recognize and respond to 'danger' signals arising from pathogens. Among those danger signals are the unmethylated CpG dinucleotide motifs found in bacteria. At least some of the recognition of these sequences is through cellular components of the innate immune syst...

journal_title：Advanced drug delivery reviews

authors： Scheule RK

更新日期：2000-11-15 00:00:00

abstract：:Infectious diseases are prevalent in the developing world and are one of the developing world's major sources of morbidity and mortality. While infectious diseases can initiate in a localized region, they can spread rapidly at any moment due to the ease of traveling from one part of the world to the next. This could l...

journal_title：Advanced drug delivery reviews

authors： Hauck TS,Giri S,Gao Y,Chan WC

更新日期：2010-03-18 00:00:00

abstract：:Posterior segment drug delivery challenges inherent in the treatment of many sight-threatening diseases have become increasingly apparent. Therapeutic interventions for ocular diseases such as neovascular retinopathies, inflammatory and/or infectious diseases may involve drug delivery to vitreoretinal targets. An impo...

journal_title：Advanced drug delivery reviews

authors： Duvvuri S,Rittenhouse KD,Mitra AK

更新日期：2005-12-13 00:00:00

abstract：:The use of liposomes as drug carriers in treatment of various diseases has been explored extensively for more than 20 years. 'Conventional' liposomes, when administered in vivo by a variety of routes, rapidly accumulate in the mononuclear phagocyte system (MPS). The inherent tendency of the liposomes to concentrate in...

journal_title：Advanced drug delivery reviews

authors： Agrawal AK,Gupta CM

更新日期：2000-03-30 00:00:00

abstract：:Amorphisation of poorly water-soluble drugs is one approach that can be applied to improve their solubility and thus their bioavailability. Amorphisation is a process that usually requires deliberate external energy input. However, amorphisation can happen both unintentionally, as in process-induced amorphisation duri...

journal_title：Advanced drug delivery reviews

authors： Priemel PA,Grohganz H,Rades T

更新日期：2016-05-01 00:00:00

abstract：:Progress in gene therapy has produced promising results that translate experimental research into clinical treatment. Gene modification has been extensively employed in cell transplantation. The main barrier is an effective gene delivery system. Several viral vectors were utilized in end-stage differentiated cells. Re...

journal_title：Advanced drug delivery reviews

authors： Lai Y,Drobinskaya I,Kolossov E,Chen C,Linn T

更新日期：2008-01-14 00:00:00

abstract：:In the past 15years, despite that regenerative medicine has shown great potential for cardiovascular diseases, the outcome and safety of stem cell transplantation has shown controversial results in the published literature. Medical imaging might be useful for monitoring and quantifying transplanted cells within the he...

journal_title：Advanced drug delivery reviews

authors： Li X,Hacker M

更新日期：2017-10-01 00:00:00

abstract：:The selection of drug candidates early in development has become increasingly important to minimize the use of animals and to avoid costly failures of drugs later in development. In vitro systems to predict and assess organ toxicity have so far been of limited value due to difficulties in demonstrating in vivo-relevan...

journal_title：Advanced drug delivery reviews

authors： Roth A,Singer T

更新日期：2014-04-01 00:00:00

abstract：:Synthetic micro/nanomotors are tiny devices than can be self-propelled or externally powered in the liquid phase by different types of energy source including but not limited to: catalytic, magnetic or acoustic. Showing a myriad of mechanical movements, building block materials, sizes, shapes and propulsion mechanisms...

journal_title：Advanced drug delivery reviews

authors： Chałupniak A,Morales-Narváez E,Merkoçi A

更新日期：2015-12-01 00:00:00

abstract：:The cellular membrane constitutes an effective barrier that offers protection for the complex, yet highly ordered, intracellular environment that defines the cell. Passage of molecules across this barrier is highly regulated and highly restricted, with molecular size being the most significant criteria. Over the last ...

journal_title：Advanced drug delivery reviews

authors： Meade BR,Dowdy SF

更新日期：2007-03-30 00:00:00

abstract：:Synthetic polymers and nanomaterials display selective phenotypic effects in cells and in the body signal transduction mechanisms involved in inflammation, differentiation, proliferation, and apoptosis. When physically mixed or covalently conjugated with cytotoxic agents, bacterial DNA or antigens, polymers can drasti...

journal_title：Advanced drug delivery reviews

authors： Kabanov AV

更新日期：2006-12-30 00:00:00

abstract：:The microdose (MD) clinical study enables to select a "better" compound for new drug candidate that shows desirable PK profiles in human. This new methodology is highly expected to streamline the drug development and to increase the success probability in the clinical trial. Since only a small amount of the test compo...

journal_title：Advanced drug delivery reviews

authors： Sugiyama Y,Yamashita S

更新日期：2011-06-19 00:00:00

abstract：:Endogenous acetylcarnitine is an indicator of acetyl-CoA synthesized by multiple metabolic pathways involving carbohydrates, amino acids, fatty acids, sterols, and ketone bodies, and utilized mainly by the tricarboxylic acid cycle. Acetylcarnitine supplementation has beneficial effects in elderly animals and humans, i...

journal_title：Advanced drug delivery reviews

authors： Rosca MG,Lemieux H,Hoppel CL

更新日期：2009-11-30 00:00:00

abstract：:A wide range of polymeric scaffolds have been intensively studied for use as implantable and temporal devices in tissue engineering. Biodegradable and biocompatible scaffolds having a highly open porous structure and good mechanical strength are needed to provide an optimal microenvironment for cell proliferation, mig...

journal_title：Advanced drug delivery reviews

authors： Chung HJ,Park TG

更新日期：2007-05-30 00:00:00

abstract：:Tip-enhanced Raman scattering (TERS) has become a powerful tool for nanoscale structural analysis for several branches of organic, inorganic, and biological chemistry. This highly sensitive technique enables molecular characterization with a lateral resolution far beyond Abbe's diffraction limit and correlates structu...

journal_title：Advanced drug delivery reviews

authors： Sharma G,Deckert-Gaudig T,Deckert V

更新日期：2015-07-15 00:00:00

abstract：:The incorporation of polymer-lipid conjugates, initially using PEG and subsequently other selected flexible, hydrophilic polymers, into lipid bilayers gives rise to sterically stabilized liposomes that exhibit reduced blood clearance and concomitant changes in tissue distribution largely because of reduced, but not el...

journal_title：Advanced drug delivery reviews

authors： Woodle MC

更新日期：1998-06-08 00:00:00

abstract：:Carbon-based functional nanomaterials have attracted immense scientific interest from many disciplines and, due to their extraordinary properties, have offered tremendous potential in a diverse range of applications. Among the different carbon nanomaterials, graphene is one of the newest and is considered the most imp...

journal_title：Advanced drug delivery reviews

authors： Zhang B,Wei P,Zhou Z,Wei T

更新日期：2016-10-01 00:00:00

abstract：:Antibodies can have exquisite specificity of target recognition and thus generate highly selective outcomes following their systemic administration. While antibodies can have high specificity, the doses required to treat patients, particularly for a chronic condition, are typically large. Fortunately, advances in prod...

journal_title：Advanced drug delivery reviews

authors： Daugherty AL,Mrsny RJ

更新日期：2006-08-07 00:00:00

abstract：:Modern pharmaceutical delivery systems are intended to produce plasma drug concentration versus time profiles that result in optimum therapeutic efficacy and a minimum of drug concentration-dependent adverse effects. To accomplish this requires that the drug delivery rate and temporal profile be based on the pharmacok...

journal_title：Advanced drug delivery reviews

authors： Levy G

更新日期：1998-09-07 00:00:00

abstract：:Safe and effective hemoglobin-based blood substitutes may be advantageous over conventional therapies for certain clinical settings requiring short term blood replacement such as emergency resuscitation and hemodilution in surgery. Many advances have been made in developing these oxygen therapeutics, however safety co...

journal_title：Advanced drug delivery reviews

authors： D'Agnillo F,Alayash AI

更新日期：2000-02-28 00:00:00

abstract：:Poly(lactic acid) (PLA), so far, is the most extensively researched and utilized biodegradable aliphatic polyester in human history. Due to its merits, PLA is a leading biomaterial for numerous applications in medicine as well as in industry replacing conventional petrochemical-based polymers. The main purpose of this...

journal_title：Advanced drug delivery reviews

authors： Farah S,Anderson DG,Langer R

更新日期：2016-12-15 00:00:00

abstract：:In the drug development process, it remains a difficult task to regulate the entry of the drugs. However, recent progress in studies of the transporter-mediated influx and efflux of endogenous and exogenous compounds, including synthetic drugs, across the blood-brain barrier (BBB) is beginning to provide a rational ba...

journal_title：Advanced drug delivery reviews

authors： Tsuji A,Tamai I I

更新日期：1999-04-05 00:00:00

abstract：:Bone metastasis occurs frequently in patients with advanced breast cancer and is a major cause of morbidity and mortality in these patients. In order to advance current therapies, the mechanisms leading to the formation of bone metastases and their pathophysiology have to be better understood. Several in vitro models ...

journal_title：Advanced drug delivery reviews

authors： Taubenberger AV

更新日期：2014-12-15 00:00:00

abstract：:All vertebrates possess mechanisms to restore damaged tissues with outcomes ranging from regeneration to scarring. Unfortunately, the mammalian response to tissue injury most often culminates in scar formation. Accounting for nearly 45% of deaths in the developed world, fibrosis is a process that stands diametrically ...

journal_title：Advanced drug delivery reviews

authors： Keane TJ,Horejs CM,Stevens MM

更新日期：2018-04-01 00:00:00

abstract：:A recombinant C-terminal truncated form of the human soluble tumor necrosis factor receptor type I (sTNF-RI) was produced in E. coli. This soluble receptor contains the first 2.6 of the 4 domains of the intact sTNF-RI molecule. A monoPEGylated form of this molecule was produced using a 30 kD methoxyPEG aldehyde with a...

journal_title：Advanced drug delivery reviews

authors： Edwards CK 3rd,Martin SW,Seely J,Kinstler O,Buckel S,Bendele AM,Ellen Cosenza M,Feige U,Kohno T

更新日期：2003-09-26 00:00:00

abstract：:Blood contact with biomaterials triggers activation of multiple reactive mechanisms that can impair the performance of implantable medical devices and potentially cause serious adverse clinical events. This includes thrombosis and thromboembolic complications due to activation of platelets and the coagulation cascade,...

journal_title：Advanced drug delivery reviews

authors： Biran R,Pond D

更新日期：2017-03-01 00:00:00

abstract：:Complex cell culture models such as microphysiological models (MPS) mimicking human liver functionality in vitro are in the spotlight as alternative to conventional cell culture and animal models. Promising techniques like microfluidic cell culture or micropatterning by 3D bioprinting are gaining increasing importance...

journal_title：Advanced drug delivery reviews

authors： Raasch M,Fritsche E,Kurtz A,Bauer M,Mosig AS

更新日期：2019-02-01 00:00:00

abstract：:Theranostic systems support diagnostic and therapeutic functions in a single integrated entity and enable precise spatiotemporal control of the generation of therapeutic molecules according to the individual patient's disease state, thereby maximizing the therapeutic outcome and minimizing side effects. These systems ...

journal_title：Advanced drug delivery reviews

authors： Kojima R,Aubel D,Fussenegger M

更新日期：2016-10-01 00:00:00

abstract：:A site-directed method of joining proteins to poly(ethylene glycol) is presented which allows for the preparation of essentially homogeneous PEG-protein derivatives with a single PEG chain conjugated to the amine terminus of the protein. This selectivity is achieved by conducting the reductive alkylation of proteins w...

journal_title：Advanced drug delivery reviews

authors： Kinstler O,Molineux G,Treuheit M,Ladd D,Gegg C

更新日期：2002-06-17 00:00:00