Abstract：
:Complex cell culture models such as microphysiological models (MPS) mimicking human liver functionality in vitro are in the spotlight as alternative to conventional cell culture and animal models. Promising techniques like microfluidic cell culture or micropatterning by 3D bioprinting are gaining increasing importance for the development of MPS to address the needs for more predictivity and cost efficiency. In this context, human induced pluripotent stem cells (hiPSCs) offer new perspectives for the development of advanced liver-on-chip systems by recreating an in vivo like microenvironment that supports the reliable differentiation of hiPSCs to hepatocyte-like cells (HLC). In this review we will summarize current protocols of HLC generation and highlight recently established MPS suitable to resemble physiological hepatocyte function in vitro. In addition, we are discussing potential applications of liver MPS for disease modeling related to systemic or direct liver infections and the use of MPS in testing of new drug candidates.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Raasch M,Fritsche E,Kurtz A,Bauer M,Mosig ASdoi
10.1016/j.addr.2018.06.008subject
Has Abstractpub_date
2019-02-01 00:00:00pages
51-67eissn
0169-409Xissn
1872-8294pii
S0169-409X(18)30147-9journal_volume
140pub_type
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journal_title：Advanced drug delivery reviews
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journal_title：Advanced drug delivery reviews
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章,评审
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journal_title：Advanced drug delivery reviews
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journal_title：Advanced drug delivery reviews
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