Abstract：
:In this randomized study we compared the efficacy of ondansetron 4 mg with ondansetron 8 mg for the prevention of postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy with sevoflurane and remifentanil infusion anaesthesia. Sixty patients were randomized to receive ondansetron 8 mg (30 pts) or ondansetron 4 mg (30 pts) before the induction of anaesthesia with thiopental and remifentanil. Anaesthesia was maintained with sevoflurane (0.5 MAC), oxygen and remifentanil infusion (0.25, 0.35, 0.5 microg/kg/min). Postoperative analgesia was provided by intravenous ketorolac 60 mg. The incidence of PONV, the pain score, and the analgesic requirement were recorded for 24 hours. There was no difference among groups in patient characteristics, risk factors for PONV, or side effects. During the first 6 h postoperatively, the incidence of PONV after ondansetron 4 mg and 8 mg were similar (p < 0.001). After 6 h the incidence of PONV increased significantly in patients who had received ondansetron 4 mg (p = 0.01) and was greater than that in patients who had received ondansetron 8 mg (p = 0.001). We conclude that single-dose ondansetron 8 mg is more effective than ondansetron 4 mg in the prevention of PONV after laparoscopic cholecystectomy. This surgery is associated with a high incidence of postoperative nausea and vomiting. A single dose of IV ondansetron 8 mg is well tolerated and decrease the number of nausea and vomiting episodes after surgery.
journal_name
Eur Rev Med Pharmacol Scijournal_title
European review for medical and pharmacological sciencesauthors
Paventi S,Santevecchi A,Ranieri Rsubject
Has Abstractpub_date
2001-03-01 00:00:00pages
59-63issue
2eissn
1128-3602issn
2284-0729journal_volume
5pub_type
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章,评审
doi：
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abstract：OBJECTIVE:To investigate the clinical efficacy of combination of mouse nerve growth factor (NGF) and nimodipine in the treatment of neonatal intracranial hemorrhage (NICH) and its effect on plasma platelet-activating factor (PAF), C-type natriuretic peptide (CNP), matrix metalloproteinase-2 (MMP-2), and neurological fu...
journal_title：European review for medical and pharmacological sciences
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abstract：:Secondary or pathologic fractures, associated with osteosarcoma, have been considered for a long time to be a negative prognosis regarding its evolution in the patients. The aim of this study was to evaluate the prognostic importance of such pathologic fractures in osteosarcoma patients receiving new therapies as well...
journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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abstract：OBJECTIVE:Alcoholic hepatitis (AH) is a type of alcoholic liver disorder caused by overconsumption of alcohol. The involvement of several transcription factors (TF), as the main regulators of disease related gene expression has been documented previously. However, despite the importance of analysis of gene regulatory n...
journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章,评审
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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