Abstract:
OBJECTIVE:To study the expression level of the long non-coding ribonucleic acid (lncRNA) KCNQ1 overlapping transcript 1 (KCNQ1OT1) in the patients with myelodysplastic syndrome (MDS), as well as the correlation between the expression level of lncRNA KCNQ1OT1 and the clinical diagnosis and prognosis of MDS. PATIENTS AND METHODS:A total of 60 MDS patients were selected as the MDS group and 20 healthy people as the control group. The expression levels of lncRNA KCNQ1OT1 in the serum of the two groups of participants were compared. The associations of the expression level of lncRNA KCNQ1OT1 with the clinicopathological parameters of the MDS patients were analyzed. MDS was divided into various subtypes in accordance with the World Health Organization (WHO) classification. The expression level of lncRNA KCNQ1OT1 in all the subtypes was detected, and its correlation with the prognosis was judged. RESULTS:There was a statistical difference in the expression level of lncRNA KCNQ1OT1 between the control group and the MDS group (p<0.001). The MDS patients with the low expression of lncRNA KCNQ1OT1 had remarkably longer survival and progression-free survival (PFS) in comparison with those with the high expression of lncRNA KCNQ1OT1 (p<0.001). The survival status and chemosensitivity of the MDS patients were closely related to the prognosis (p<0.001). CONCLUSIONS:LncRNA KCNQ1OT1 presents high expressions in the MDS patients, indicating that it has a correlation with the prognosis of the MDS patients, and thus providing a new direction for the future treatment of the MDS patients.
journal_name
Eur Rev Med Pharmacol Scijournal_title
European review for medical and pharmacological sciencesauthors
Zhang SF,Jin L,Chen YFdoi
10.26355/eurrev_202005_21341subject
Has Abstractpub_date
2020-05-01 00:00:00pages
5558-5563issue
10eissn
1128-3602issn
2284-0729journal_volume
24pub_type
杂志文章abstract:OBJECTIVE:Radial artery occlusion is a potential complication of transradial procedures and its occurrence ranges from 0.8 to 30%. It is virtually always asymptomatic but the functional and sensorial consequences of a long acting hand hypoperfusion could go underestimated. CardioWaves is a novel photoplethysmograh devi...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2015-08-01 00:00:00
abstract::In 2015 bladder cancer was the fourth most frequent malignancy and the eighth cause of death for cancer. At diagnosis, about 30% of bladder cancer (BC) patients present a muscle-invasive bladder cancer (MIBC) and 5% a metastatic bladder carcinoma (MBC). For fit MBC patients, combination chemotherapy (CC) is the standa...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_202011_23795
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journal_title:European review for medical and pharmacological sciences
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更新日期:2014-01-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
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doi:10.26355/eurrev_201902_17096
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journal_title:European review for medical and pharmacological sciences
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2014-01-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
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doi:10.26355/eurrev_202003_20689
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journal_title:European review for medical and pharmacological sciences
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doi:
更新日期:2016-01-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_202001_20046
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
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abstract::No Abstract Available. ...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_202004_20874
更新日期:2020-04-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2017-10-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
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doi:
更新日期:2016-11-01 00:00:00
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更新日期:2019-04-01 00:00:00
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doi:10.26355/eurrev_201803_14486
更新日期:2018-03-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2012-11-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_201804_14723
更新日期:2018-04-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
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journal_title:European review for medical and pharmacological sciences
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更新日期:2019-06-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
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更新日期:2011-05-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
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更新日期:2017-07-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_202011_23610
更新日期:2020-11-01 00:00:00
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更新日期:2020-06-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章,评审
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更新日期:2020-12-01 00:00:00