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A two-phase pathogenesis of graft-versus-host disease in mice.

Abstract：

:Activation of donor T cells is required for the development of graft-versus-host disease (GVHD), a major complication of bone marrow transplantation. We investigated a murine model of GVHD across major and minor histocompatibility barriers. BALB/c recipients were lethally irradiated and transplanted with 10(7) bone marrow and 5 x 10(6) spleen cells from C57BL/6 donors. There were two separate phases of clinical disease. The first phase was most severe on day 7 after transplant. Weight and condition improved until day 12 and then a second phase of clinical GVHD commenced, which persisted until euthanasia. IL-2 mRNA expression, as a measure of T cell activation, was determined by quantitative PCR. The two phases of clinical GVHD were preceded by two separate peaks of IL-2 mRNA in the spleen. Host MHC class II(+) cells became undetectable by flow cytometry 7 days after transplantation, whereas donor MHC class II(+) cells increased during the first 9 days after transplantation. Removal of donor MHC class II(+) cells from the graft had no effect on the first phase. Possible roles for host and donor antigen-presenting cells (APC) in the two phases of the disease are discussed.

journal_name

Bone Marrow Transplant

journal_title

Bone marrow transplantation

authors

van Leeuwen L,Guiffre A,Atkinson K,Rainer SP,Sewell WA

doi

10.1038/sj.bmt.1703328

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

151-8

issue

2

eissn

0268-3369

issn

1476-5365

journal_volume

29

pub_type

杂志文章

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