Alefacept treatment for refractory chronic extensive GVHD.

Abstract:

:Alefacept (Amevive) is an immunosuppressive dimeric fusion protein that is used for psoriasis control. We recently showed its effect in acute steroid-resistant/dependent GVHD. In this study, we describe the effect of alefacept treatment on chronic extensive GVHD (cGVHD). Twelve patients were included in this study; of these 8 (9 of 13 episodes) showed response. The median time to initial response was 2.25 weeks and the response was marked (n=3), moderate (n=2) or minimal (n=4). In two responding patients, the response was only temporary. Complications that appeared during treatment included infection, pericarditis and squamous cell carcinoma of the lip. All these events may be related to other drugs given simultaneously. With a 30-month median follow-up, 6 of 12 patients are alive, with all but one with stable or improved cGVHD. Six patients died because of GVHD progression, whereas none of the patients experienced relapse of the disease for which the transplantation was done. As reported earlier in psoriatic patients treated with alefacept, we found a consistent increase in the percentage of naive T cells as a consequence of treatment. In conclusion, alefacept is effective for the treatment of cGVHD, and dose and time intervals of treatment should be explored further.

journal_name

Bone Marrow Transplant

authors

Shapira MY,Abdul-Hai A,Resnick IB,Bitan M,Tsirigotis P,Aker M,Gesundheit B,Slavin S,Or R

doi

10.1038/bmt.2008.324

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

339-43

issue

4

eissn

0268-3369

issn

1476-5365

pii

bmt2008324

journal_volume

43

pub_type

杂志文章
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    doi:

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    更新日期:1996-05-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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    doi:10.1038/sj.bmt.1700847

    authors: Toren A,Or R,Ackerstein A,Nagler A

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    pub_type: 杂志文章

    doi:10.1038/sj.bmt.1701616

    authors: Blazsek I,Delmas Marsalet B,Legras S,Marion S,Machover D,Misset JL

    更新日期:1999-04-01 00:00:00

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    authors: Leibundgut K,von Rohr A,Brülhart K,Hirt A,Ischi E,Jeanneret C,Muff J,Ridolfi-Lüthy A,Wagner HP,Tobler A

    更新日期:1995-01-01 00:00:00

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    doi:

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    doi:

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    更新日期:2006-05-01 00:00:00

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    authors: Randall J,Keven K,Atli T,Ustun C

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    journal_title:Bone marrow transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Aurer I,Gale RP

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    doi:10.1038/sj.bmt.1701022

    authors: Lawton CA,Cohen EP,Murray KJ,Derus SW,Casper JT,Drobyski WR,Horowitz MM,Moulder JE

    更新日期:1997-12-01 00:00:00

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    journal_title:Bone marrow transplantation

    pub_type: 杂志文章

    doi:

    authors: Touraine JL,Raudrant D,Rebaud A,Roncarolo MG,Laplace S,Gebuhrer L,Betuel H,Frappaz D,Freycon F,Zabot MT

    更新日期:1992-01-01 00:00:00