Abstract:
:We report here the efficacy of amantadine hydrochloride for two patients with alternating hemiplegia of childhood (AHC) that did not respond to flunarizine. Amantadine was administered to one patient at age one year and seven months and to the other at age 25 years. The frequencies and duration of the hemiplegic attacks significantly improved in both patients. However, the attacks gradually returned to the previous level after a significant reduction in seizures for three years in the younger patient with ongoing AHC. Our therapeutic results further support the hypothesis that glutamate and NMDA receptors are involved in inducing alternating hemiplegic attacks, because amantadine as well as its derivative, memantine, are clinically available non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, with neuroprotective effects. Amantadine is worth trying when treating patients with AHC as a first trial or a substitute for flunarizine once the latter agent looses effect.
journal_name
Neuropediatricsjournal_title
Neuropediatricsauthors
Sone K,Oguni H,Katsumori H,Funatsuka M,Tanaka T,Osawa Mdoi
10.1055/s-2000-12945subject
Has Abstractpub_date
2000-12-01 00:00:00pages
307-9issue
6eissn
0174-304Xissn
1439-1899journal_volume
31pub_type
杂志文章相关文献
NEUROPEDIATRICS文献大全abstract::18F fluorodeoxyglucose (18FDG) and positron tomography (PT) were used in 20 full term babies with seizures or hypotonia to describe regional cerebral glucose metabolism. Among babies with seizures, birth asphyxia was the most common cause. PT was performed at age 6-17 days. One hour before PT, 18FDG (50-100 microCi/kg...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1052419
更新日期:1988-08-01 00:00:00
abstract::Rett syndrome is a neurological disorder associated with cortical atrophy, stereotyped hand movements, dementia, and extrapyramidal dysfunction. Endogenous levels of dopamine and its metabolites are decreased throughout the neocortex and basal ganglia and the number of dopamine type 2 receptors are decreased in the pu...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-979741
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVES:The present study investigates the effect of topical injections of botulinum toxin A into the cephalic salivary glands of children with chronic hypersalivation due to neurodegenerative diseases. METHODS:Five children with hypersalivation due to severe neurological diseases received, under ultrasound guidanc...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2002-37084
更新日期:2002-12-01 00:00:00
abstract::The content of free amino acids in the cerebrospinal fluid from 52 children in different age groups with febrile seizures were determined and compared to 88 age matched children without seizures. We found that the concentrations of some amino acids in CSF in the control group decreased slowly with age, reaching the co...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1071277
更新日期:1989-08-01 00:00:00
abstract::We report the occurrence of subacute sclerosing panencephalitis (SSPE) in two brothers two years after measles infection. The diagnosis was confirmed by compatible data from medical history, occurrence of autochthonic measles virus (MV) IgG production in the central nervous system (CNS), and pathognomonic EEG changes....
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2003-44672
更新日期:2003-12-01 00:00:00
abstract::Introduction Guillain-Barré syndrome (GBS) is an autoimmune peripheral neuropathy characterized by demyelination and axonal damage. Biallelic functional polymorphisms in the immunoglobulin G Fc receptors (FcγR)-FcγRIIA: H131/R131, FcγRIIIA: V158/F158, and FcγRIIIB: NA1/NA2 affect the affinity of the IgG-FcγR interacti...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0036-1579633
更新日期:2016-06-01 00:00:00
abstract::Careful clinical delineation and advances in analytical methods have opened new possibilities for the detection of inherited neurometabolic disorders, some of which require specific CSF analyses for diagnosis. Although patients suffering from these disorders have recognizable phenotypes, there are strong indications t...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-2007-973538
更新日期:1998-04-01 00:00:00
abstract:AIM: Attention deficit with or without hyperactivity (AD[H]D) is a common comorbidity of neurofibromatosis type 1 (NF 1). We tested the hypothesis that permanent medication with methylphenidate can improve cognitive functioning in children with NF 1 and comorbid AD(H)D. PATIENTS AND METHOD: We retrospectively analyzed...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0034-1368117
更新日期:2014-08-01 00:00:00
abstract::We report antiphospholipid antibody positivity in three of a consecutive series of 23 children presenting partial epileptic seizures. There was no clinical or serological evidence of systemic lupus erythematosus or other connective-tissue disease. Neither computed tomography nor magnetic resonance imaging revealed isc...
journal_title:Neuropediatrics
pub_type: 临床试验,杂志文章
doi:10.1055/s-2007-973570
更新日期:1998-10-01 00:00:00
abstract::We report a newborn with exaggerated startle reactions and stiffness of neonatal onset, the prototypical signs of hyperekplexia. Startle and flexor spasms, leading to apnoea, did not respond to treatment with clonazepam but did partially to sodium valproate. Molecular analysis of GLRA1 revealed no mutations. The incid...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2005-872877
更新日期:2005-12-01 00:00:00
abstract::An 11-year-old boy with attention deficit/hyperactivity disorder (ADHD) presented with visual hallucinations several years after starting methylphenidate (MPH). The hallucinations resolved upon discontinuation of the drug. Reports of toxic hallucinosis during treatment with MPH are rare. Although the pathogenetic mech...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0031-1275738
更新日期:2011-02-01 00:00:00
abstract::We report on 12 children with neuronal ceroid lipofuscinosis (NCL) diagnosed between 1974-1995 in the West of Scotland. Diagnosis was made on the basis of clinical, electrophysiological, radiological and pathological examination including electron microscopy (EM) in all cases. Incidence was calculated on the basis of ...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-2007-973690
更新日期:1997-06-01 00:00:00
abstract::We report the clinico-pathological findings regarding a 9 year-old girl with some clinical features of Kleine-Levin syndrome who died suddently as a result of pulmonary embolism in the course of femoro-iliac thrombophlebitis. Neuropathological examination provided evidence of perivascular inflammatory infiltrates and ...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1071559
更新日期:1993-10-01 00:00:00
abstract::Functional MRI mapping of language areas in children frequently employs a covert verb generation task. Because responses are not monitored, the relationship between fMRI activation and task performance is unknown. We compared fMRI activation during covert and overt verb generation to performance during the overt task....
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0030-1267982
更新日期:2010-10-01 00:00:00
abstract::Four cases of periventricular ischemia without hemorrhage in premature infants are described in which positive rolandic sharp waves (PRSW) were predominant in the electroencephalogram (EEG). These findings suggest the relationship of PRSW to periventricular ischemia rather than to intraventricular hemorrhage, per se, ...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1052529
更新日期:1986-11-01 00:00:00
abstract::Birth asphyxia is a major concern in neonatal care. Epileptic seizures are associated with subsequent neurodevelopmental deficits. Eighty-five percent of these seizures remain subclinical and therefore an on-line monitoring device is needed. In an earlier study we showed that the synchronization likelihood was able to...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2004-830367
更新日期:2004-12-01 00:00:00
abstract::Two boys developed rhythmic involuntary movements in the extremities on one side of the body after febrile illness. They also showed behavioral disturbances. In both patients, serum antistreptolysin-O and antistreptokinase titers were elevated in acute illness and decreased a few months later. One patient showed tremo...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2000-7476
更新日期:2000-04-01 00:00:00
abstract::Two children with biotinidase deficiency presented with seizures at 2 months of age. The first child had a fluctuating course with continual developmental progress and cessation of seizures despite symptoms of chronic neurologic dysfunction until he was diagnosed at 17 months. The second child had a progressive course...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1071543
更新日期:1993-08-01 00:00:00
abstract::We describe a rare case of diffuse leptomeningeal oligodendrogliomatosis associated with the human herpes virus 6 variant A (HHV-6 A). A 2-year-old boy presented with progressive neurological symptoms and hydrocephalus. The patient had a VP shunt placement but did not fully recover. HHV-6 A was detected in both CSF an...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2002-36739
更新日期:2002-10-01 00:00:00
abstract::Acute herpes simplex encephalitis (HSE) carries significant morbidity and mortality even after early treatment with antiviral agents (7). As well as causing acute neurological disease, Herpes viruses are associated with relapsing--remitting (Varicella--Zoster, Epstein-Barr) and chronic (Rasmussen encephalitis) disease...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-973546
更新日期:1998-06-01 00:00:00
abstract::The carboxyl terminal of the predicted amino acid sequence of the Batten disease CLN3 gene protein is CQLS. This motif is expected to be a site for farnesylation at the cysteine residue. In order to determine whether this is indeed farnesylated we have carried out the in-vitro prenylation of tetrapeptides CVLS, CAIL a...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-973665
更新日期:1997-02-01 00:00:00
abstract::While prognostic information for Dandy-Walker syndrome and non-progressive cerebellar ataxia/cerebellar hypoplasia is available, surprisingly scant literature reports are found for space-occupying posterior fossa arachnoid cysts (PFAC). We describe the outcome of patients with symptomatic PFAC shunted as infants. Only...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2002-33674
更新日期:2002-06-01 00:00:00
abstract::Over the past few years there has been increasing awareness of the association of congenital choanal atresia (CCA) with other congenital defects, including brain abnormalities. We obtained CT scans of the brain in twenty-three consecutive patients with CCA (10 boys and 13 girls) to determine the prevalence and the sco...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1071591
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:Danon disease is caused by a primary deficiency of lysosome-associated membrane protein-2 (LAMP-2). MATERIALS AND METHODS:Our study describes a 19-year-old man with isolated hypertrophic cardiomyopathy, in whom we performed DNA analysis and compared results of microscopic analysis of skeletal and cardiac mu...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0033-1336017
更新日期:2013-10-01 00:00:00
abstract::We are reporting the unique coexistence of two distinct neuromuscular diseases, myotonic dystrophy and the juvenile form of myasthenia gravis, occurring in one family. A 16-month-old previously healthy female presented with a two month history of bilateral varying drooping of both eyelids and bilateral external ophtha...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1052426
更新日期:1987-02-01 00:00:00
abstract::In two children affected with "Epilepsia Partialis Continua" (EPC) of progressive type, probably secondary to a slow encephalitis, the percentage of T-lymphocytes in CSF was lower than normal (30% compared to 90%). The CSF-T-lymphocytes are characterized by their ability to form E-rosettes. In one patient signs of int...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1071482
更新日期:1990-08-01 00:00:00
abstract::A newborn with a rare type of lissencephaly is reported, characterized by extreme cerebral and cerebellar hypoplasia. The diagnosis was made by postmortem magnetic resonance imaging, indicating the value of such studies to evaluate neuronal migration disorders in patients in whom autopsy cannot be performed. Two earli...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-973778
更新日期:1996-10-01 00:00:00
abstract::The definition and the clinical picture of arthrogryposis multiplex congenita (AMC) are discussed and the associated anomalies, deformities and syndromes are listed. It is stressed that isolated congenital contractures in (progressive) neuromuscular disorders may be manifestations of AMC, dependent on the moment of th...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1059546
更新日期:1983-02-01 00:00:00
abstract::A number of frequently prescribed gastrointestinal drugs can cause movement disorders in children, as well as in adults. In our centre for paediatric neurology, we saw a 3-year-old girl with abnormal movements mostly of the legs with an inner restlessness (akathisia) while using cisapride. Another patient, a 17-year-o...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2006-923981
更新日期:2006-04-01 00:00:00
abstract::Infant botulism is caused by intestinal colonization by Clostridium botulinum, C. barati or C. butyricum. Infant botulism has only rarely been reported outside the USA. A 3-month-old boy developed constipation, lethargy, feeding difficulties and descending, severe, symmetric weakness. He was breastfed but had also bee...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-973716
更新日期:1997-10-01 00:00:00