Metabolic and cardiovascular effects of isoprenaline and salbutamol in the dog.

abstract：:1. The effects of various metabotropic glutamate receptor agonists on [3H]-cyclic AMP accumulation and phosphoinositide hydrolysis were investigated in guinea-pig cerebral cortical slices prelabelled with [3H]-adenine or [3H]-inositol. 2. 1-Aminocyclopentane-1S,3R-dicarboxylate (1S,3R-ACPD), L-2-amino-4-phosphonobutan...

journal_title：British journal of pharmacology

authors： Cartmell J,Kemp JA,Alexander SP,Shinozaki H,Kendall DA

更新日期：1994-01-01 00:00:00

abstract：:1. In order to investigate the vasodilator mechanisms of the K+ channel openers, cromakalim, pinacidil and nicorandil, we measured changes in cytoplasmic Ca2+ concentration [( Ca2+]i) simultaneously with force by a microfluorimetric method using fura-2, a calcium indicator, in canine coronary arterial smooth muscle ce...

journal_title：British journal of pharmacology

authors： Yanagisawa T,Teshigawara T,Taira N

更新日期：1990-09-01 00:00:00

abstract：:(1) Here, we introduce a beta-casomorphin-5-derived cyclic pentapeptide, cCD-2 (Tyr-cyclo[d-Orn-Tyr(Bzl)-Pro-Gly]), which inhibits the cell growth of a variety of human cancer cell lines. (2) This opioid-derived peptide possesses only low affinity for mu-receptors, but enhances the agonist binding to mu-receptors in v...

journal_title：British journal of pharmacology

authors： Stirnweiss J,Hartrodt B,Greksch G,Stürzebecher U,Böhmer FD,Neubert K,Liebmann C

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Up-regulation of thioredoxin interacting protein (TXNIP), an endogenous inhibitor of thioredoxin (Trx), compromises cellular antioxidant and anti-apoptotic defences and stimulates pro-inflammatory cytokines expression, implying a role for TXNIP in apoptosis. Here we have examined the causal role ...

journal_title：British journal of pharmacology

authors： Al-Gayyar MM,Abdelsaid MA,Matragoon S,Pillai BA,El-Remessy AB

更新日期：2011-09-01 00:00:00

abstract：:The mechanism underlying the LTC(4)-induced contraction of guinea-pig taenia coli was determined using the simultaneous measurements of [Ca(2+)](i) and force in whole muscle preparations. Additional experiments were performed in receptor coupled permeabilized preparation. For comparison purposes, the contraction which...

journal_title：British journal of pharmacology

authors： Ieiri S,Nishimura J,Hirano K,Suita S,Kanaide H

更新日期：2001-06-01 00:00:00

abstract：:1. Moclobemide (MB) is an antidepressant drug that selectively and reversibly inhibits monoamine oxidase-A. Recent studies have revealed that antidepressant drugs possess the characters of potent growth-promoting factors for the development of neurogenesis and improve the survival rate of serotonin (5-hydroxytrytamine...

journal_title：British journal of pharmacology

authors： Chiou SH,Ku HH,Tsai TH,Lin HL,Chen LH,Chien CS,Ho LL,Lee CH,Chang YL

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The histamine H4 receptor is widely expressed in cells of immune origin and has been shown to play a role in a variety of inflammatory processes mediated by histamine. In this report, we describe the in vitro and in vivo anti-inflammatory properties of a potent histamine H4 receptor antagonist, A...

journal_title：British journal of pharmacology

authors： Strakhova MI,Cuff CA,Manelli AM,Carr TL,Witte DG,Baranowski JL,Vortherms TA,Miller TR,Rundell L,McPherson MJ,Adair RM,Brito AA,Bettencourt BM,Yao BB,Wetter JM,Marsh KC,Liu H,Cowart MD,Brioni JD,Esbenshade TA

更新日期：2009-05-01 00:00:00

abstract：:1. The aims of the present study were to determine whether long-term 5-hydroxytryptamine (5-HT) reuptake blockade and inhibition of type-A monoamine oxidase (MAO-A) lead to an enhancement of the electrically evoked release of tritum from guinea-pig brain slices preloaded with [3H]-5-HT, and to assess the sensitivity o...

journal_title：British journal of pharmacology

authors： Blier P,Bouchard C

更新日期：1994-10-01 00:00:00

abstract：:1. Intravenous administration of leukotriene C4 (LTC4) and LTD4 (1-10 nmol kg-1) caused a dose-dependent increase in secretion of glandular-kallikrein in the bronchial washings of guinea-pigs, as measured by cleavage of a synthetic substrate and the formation of kinin. LTC4 was more potent than LTD4 and pilocarpine wa...

journal_title：British journal of pharmacology

authors： Jin HY,Katori M,Majima M,Sunahara N

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To study the importance of endothelium-derived contracting factors (EDCFs) in arteries of rats with type I diabetes. EXPERIMENTAL APPROACH:Rat femoral arteries were collected four or twelve weeks after induction of diabetes with streptozotocin. Rings, with or without endothelium, were suspended ...

journal_title：British journal of pharmacology

authors： Shi Y,Feletou M,Ku DD,Man RY,Vanhoutte PM

更新日期：2007-03-01 00:00:00

abstract：:1. In the present study, the properties of glaucine (an aporphine structurally related to papaverine) were compared with those of papaverine, diltiazem, nifedipine and prazosin. The work includes functional studies on rat isolated aorta contracted with noradrenaline, caffeine or KCl, and a determination of the affinit...

journal_title：British journal of pharmacology

authors： Ivorra MD,Lugnier C,Schott C,Catret M,Noguera MA,Anselmi E,D'Ocon P

更新日期：1992-06-01 00:00:00

abstract：:1. The purpose of the present study was to develop an experimental strategy for the quantification of the cardiovascular effects of non-selective adenosine receptor ligands at the adenosine A1 and A2a receptor in vivo. 2-Chloroadenosine (CADO) was used as a model compound. 2. Three groups of normotensive conscious rat...

journal_title：British journal of pharmacology

authors： Mathoôt RA,Soudijn W,Breimer DD,Ijzerman AP,Danhof M

更新日期：1996-05-01 00:00:00

abstract：:Topical ophthalmic formulations of analogues of the endogenous arachidonic acid cyclooxygenase metabolite, PGF2α , are the standard of care treatment for the blinding disease glaucoma. These are the most potent and efficacious medical therapies for lowering intraocular pressure (IOP), the most important risk factor id...

journal_title：British journal of pharmacology

authors： Klimko PG,Sharif NA

更新日期：2019-04-01 00:00:00

abstract：:1. The mechanisms involved in tachykinin-induced oedema were investigated in rat skin and interactions between the tachykinins and calcitonin gene-related peptide (CGRP) were studied. 2. Intradermal injections of the tachykinins, substance P, neurokinin A and neurokinin B, stimulated local oedema formation which was i...

journal_title：British journal of pharmacology

authors： Brain SD,Williams TJ

更新日期：1989-05-01 00:00:00

abstract：:5-Hydroxytryptamine (5-HT) evoked potent contractile responses in phenoxybenzamine-treated ring segments of rat caudal artery, partially contracted with U46619. Responses were mimicked by 5-HT1-selective agonists with the potency order: RU24969 > 5-carboxamidotryptamine > 5-HT = CP-93,129 > sumatriptan. 8-Hydroxy-N,N-...

journal_title：British journal of pharmacology

authors： Craig DA,Martin GR

更新日期：1993-07-01 00:00:00

abstract：:The effects of treatment with rolipram, a specific phosphodiesterase IV inhibitor, on learning and memory function and on the cyclic AMP/PKA/CREB signal transduction system were examined in rats with microsphere embolism (ME)-induced cerebral ischaemia. Sustained cerebral ischaemia was induced by the injection of 900 ...

journal_title：British journal of pharmacology

authors： Nagakura A,Niimura M,Takeo S

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In addition to typical GPCR kinase (GRK)-/β-arrestin-dependent internalization, dopamine D3 receptor employed an additional GRK-independent sequestration pathway. In this study, we investigated the molecular mechanism of this novel sequestration pathway. EXPERIMENTAL APPROACH:Radioligand binding...

journal_title：British journal of pharmacology

authors： Min C,Zheng M,Zhang X,Caron MG,Kim KM

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Combretastatin A-4 3-O-phosphate (CA4P) is in clinical trial as a tumour vascular disrupting agent (VDA) but the cause of blood flow disruption is unclear. We tested the hypothesis that activation of Rho/Rho kinase (ROCK) is fundamental to the effects of this drug in vivo. EXPERIMENTAL APPROACH:...

journal_title：British journal of pharmacology

authors： Williams LJ,Mukherjee D,Fisher M,Reyes-Aldasoro CC,Akerman S,Kanthou C,Tozer GM

更新日期：2014-11-01 00:00:00

abstract：:1. Intra-arterial blood pressures and heart rates were recorded in conscious, unrestrained, Long Evans and Brattleboro rats receiving sequential, continuous administrations of selective alpha 1- (prazosin) and alpha 2- (idazoxan) adrenoceptor antagonists. The same protocols were also run in the presence of ICI 118551 ...

journal_title：British journal of pharmacology

authors： Gardiner SM,Bennett T

更新日期：1988-01-01 00:00:00

abstract：:1. A technique for the close-arterial administration of substances to the rat stomach in vivo has been developed. 2. Intra-arterial infusion of platelet-activating factor (Paf, 10-50 ng kg-1 min-1 for 10 min) induced macroscopically assessed damage in the corpus mucosa, characterized as vasocongestion and necrosis. 3....

journal_title：British journal of pharmacology

authors： Esplugues JV,Whittle BJ

更新日期：1988-01-01 00:00:00

abstract：:1. The effects of the lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA) on the ionic currents of rat carotid body type I cells were investigated by use of whole-cell and outside-out patch clamp techniques. 2. NDGA (5-50 microM) produced a concentration-dependent inhibition of whole-cell K+ currents at all activa...

journal_title：British journal of pharmacology

authors： Hatton CJ,Peers C

更新日期：1997-11-01 00:00:00

abstract：:1. We measured the effects of agonists and antagonists of metabotropic glutamate (mGlu) receptors (types 1 and 5) on NMDA-induced depolarization of mouse cortical wedges in order to characterize the mGlu receptor type responsible for modulating NMDA responses. We also characterized a number of mGlu receptor agents by ...

journal_title：British journal of pharmacology

authors： Attucci S,Carlà V,Mannaioni G,Moroni F

更新日期：2001-02-01 00:00:00

abstract：:1. The purpose of this study was to compare the pharmacological properties (i.e. the AV nodal depressant, vasodilator, and inotropic effects) of two AV nodal blocking agents belonging to different drug classes; a novel A1 adenosine receptor (A1 receptor) agonist, N-(3(R)-tetrahydrofuranyl)-6-aminopurine riboside (CVT-...

journal_title：British journal of pharmacology

authors： Snowdy S,Liang HX,Blackburn B,Lum R,Nelson M,Wang L,Pfister J,Sharma BP,Wolff A,Belardinelli L

更新日期：1999-01-01 00:00:00

abstract：:Obesity is a common metabolic disorder that has become a widespread epidemic in several countries. Sex and gender disparities in the prevalence of cardiovascular disease (CVD) have been well documented with premenopausal women having a lower incidence of CVD than age-matched men. However, women are more likely than me...

journal_title：British journal of pharmacology

authors： Taylor LE,Ramirez LA,Musall JB,Sullivan JC

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although there are many new specific phosphodiesterase inhibitors with anti-inflammatory activity, none have yet reached the market because of their low therapeutic efficacy. Our study was aimed to evaluate the anti-inflammatory and anti-arthritic effect of an established phosphodiesterase inhibi...

journal_title：British journal of pharmacology

authors： Gomaa A,Elshenawy M,Afifi N,Mohammed E,Thabit R

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Montelukast and S-carbocysteine have been used in asthmatic patients as an anti-inflammatory or mucolytic agent respectively. S-carbocysteine also exhibits anti-inflammatory properties. EXPERIMENTAL APPROACH:Ovalbumin (OVA) sensitized BALB/c mice were challenged with OVA for 3 days followed by s...

journal_title：British journal of pharmacology

authors： Takeda K,Shiraishi Y,Matsubara S,Miyahara N,Matsuda H,Okamoto M,Joetham A,Gelfand EW

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cannabis extracts and several cannabinoids have been shown to exert broad anti-inflammatory activities in experimental models of inflammatory CNS degenerative diseases. Clinical use of many cannabinoids is limited by their psychotropic effects. However, phytocannabinoids like cannabidiol (CBD), d...

journal_title：British journal of pharmacology

authors： Kozela E,Lev N,Kaushansky N,Eilam R,Rimmerman N,Levy R,Ben-Nun A,Juknat A,Vogel Z

更新日期：2011-08-01 00:00:00

abstract：:1. We investigated the nitric oxide (NO) dependence of vasorelaxation in response to different calcium channel blockers (CCB), in rabbit femoral artery in vivo. 2. Anaesthetized rabbits underwent femoral artery ligation, and blood from the proximal artery was returned distal to the ligature through a constant infusion...

journal_title：British journal of pharmacology

authors： Xu B,Xiao-hong L,Lin G,Queen L,Ferro A

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inhaled glucocorticoid (ICS)/long-acting β2 -adrenoceptor agonist (LABA) combination therapy is a recommended treatment option for patients with moderate/severe asthma in whom adequate control cannot be achieved by an ICS alone. Previously, we discovered that LABAs can augment dexamethasone-induc...

journal_title：British journal of pharmacology

authors： Joshi T,Johnson M,Newton R,Giembycz MA

更新日期：2015-05-01 00:00:00

abstract：:Anthracyclines can cause cumulative dose-related cardiotoxicity characterized by changes in Ca(2+) metabolism, including dysfunction of the sacroplasmic reticulum (SR) and decreased expression of Ca(2+)-handling proteins, such as the ryanodine receptor (RyR2). In this study, we examined the effect of dexrazoxane (ICRF...

journal_title：British journal of pharmacology

authors： Burke BE,Gambliel H,Olson RD,Bauer FK,Cusack BJ

更新日期：2000-09-01 00:00:00