当前位置： SCI文献检索 > ALIMENTARY PHARMACOLOGY & THERAPEUTICS期刊下所有文献 > There are some benefits for eradicating Helicobacter pylori in patients with non-ulcer dyspepsia.

There are some benefits for eradicating Helicobacter pylori in patients with non-ulcer dyspepsia.

Abstract：

BACKGROUND:The relationship between Helicobacter pylori infection and non-ulcer dyspepsia is not established. AIM:To determine whether eradication of H. pylori might be of benefit in non-ulcer dyspepsia patients. METHODS:We randomly assigned 129 H. pylori infected patients with severe epigastric pain, without gastro-oesophageal reflux symptoms, to receive twice daily treatment with 300 mg of ranitidine, 1000 mg of amoxicillin, and 500 mg of clarithromycin for 7 days and 124 such patients to receive identical-appearing placebos. RESULTS:Treatment was successful (decrease of symptoms at 12 months) in 62% of patients in the active-treatment group and in 60% of the placebo group (N.S.). At 12 months, the rate of eradication of H. pylori was 69% in the active-treatment group and 18% in the placebo group (P < 0.001). Complete relief of symptoms occurred significantly more frequently in patients on the active treatment (43%) than in placebo-treated patients (31%, P=0.048). Within the active-treatment group, therapeutic success was significantly more frequent in the non-infected patients (84% vs. 64%, P=0.04). CONCLUSIONS:Although eradicating H. pylori is not likely to relieve symptoms in the majority of patients with non-ulcer dyspepsia, a small proportion of H. pylori-infected patients may benefit from eradication treatment.

journal_name

Aliment Pharmacol Ther

journal_title

Alimentary pharmacology & therapeutics

authors

Bruley Des Varannes S,Fléjou JF,Colin R,Zaïm M,Meunier A,Bidaut-Mazel C

doi

10.1046/j.1365-2036.2001.01014.x

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

1177-85

issue

8

eissn

0269-2813

issn

1365-2036

pii

apt1014

journal_volume

15

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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