Classification of dyspepsia and response to treatment with proton-pump inhibitors.

abstract：AIM:To investigate the incidence of death in patients diagnosed with Crohn's disease in Cardiff over 20 years ago. METHODS:The Cardiff database of patients with Crohn's disease contains data on all patients diagnosed there since 1934. Patients (394) diagnosed before 1 January 1985 were traced and their mortality statu...

journal_title：Alimentary pharmacology & therapeutics

authors： Canavan C,Abrams KR,Hawthorne B,Mayberry JF

更新日期：2007-01-01 00:00:00

abstract：AIM:To assess the efficacy and tolerance of sodium alginate compared to cisapride in patients suffering from reflux symptoms, without severe oesophagitis. METHODS:A total of 353 patients with symptoms of reflux oesophagitis (average age 40 years, 51% men, 33% smokers, 43% consumers of alcoholic drinks) were selected a...

journal_title：Alimentary pharmacology & therapeutics

authors： Poynard T,Vernisse B,Agostini H

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:The gastric juice concentration of vitamin C is reduced in subjects with elevated intragastric pH. This is probably because of the fact that the vitamin is unstable at non-acidic pH and undergoes irreversible denaturation. AIM:To determine whether elevation of intragastric pH reduces the bioavailability of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Henry EB,Carswell A,Wirz A,Fyffe V,McColl KE

更新日期：2005-09-15 00:00:00

abstract：BACKGROUND:[corrected] A predictable consequence of cholestasis is malabsorption of fat-soluble factors, (vitamins A, D, E, K) and other free radical scavengers, such as carotenoids. It has been suggested that oxygen-derived free radicals may be involved in the pathogenesis of chronic liver damage. AIMS:(i) To evaluat...

journal_title：Alimentary pharmacology & therapeutics

authors： Floreani A,Baragiotta A,Martines D,Naccarato R,D'odorico A

更新日期：2000-03-01 00:00:00

abstract：:The efforts of clinical researchers, lay organizations and pharmaceutical companies have increased the public profile of irritable bowel syndrome and made it a respectable diagnosis. Diagnostic symptom criteria encourage a firm clinical diagnosis, which is the foundation of a logical management strategy. This begins w...

journal_title：Alimentary pharmacology & therapeutics

authors： Thompson WG

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:In patients with idiopathic non-cirrhotic portal hypertension (INCPH), the usual recommended strategy for management of variceal bleeding is the same as that in cirrhosis. However, this policy has been challenged by the different natural history between INCPH and cirrhosis. AIM:To compare outcomes after tra...

journal_title：Alimentary pharmacology & therapeutics

authors： Lv Y,Li K,He C,Luo B,Zhang B,Liu H,Wang Z,Guo W,Wang Q,Chen H,Bai W,Yuan X,Yu T,Li X,Yuan J,Han N,Zhu Y,Niu J,Xie H,Wang J,Chen L,Yin Z,Fan D,Li Z,Han G

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Diagnosis of inflammatory bowel disease (IBD) is based on clinical presentation, colonoscopy and histology. Differentiation of Crohn's disease (CD) and ulcerative colitis (UC) can be difficult in some patients. Endoscopic ultrasound (EUS) provides high resolution images of the gastrointestinal wall (GI) and ...

journal_title：Alimentary pharmacology & therapeutics

authors： Ellrichmann M,Wietzke-Braun P,Dhar S,Nikolaus S,Arlt A,Bethge J,Kuehbacher T,Wintermeyer L,Balschun K,Klapper W,Schreiber S,Fritscher-Ravens A

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:CXC chemokines such as interleukin (IL)-8 are neutrophil chemoattractants, the levels of which increase in Helicobacter pylori-infected gastric mucosa. Many investigators have focused on the chemotactic aspects of IL-8: however, CXC chemokines are also reported to have angiogenic activity and to serve as rem...

journal_title：Alimentary pharmacology & therapeutics

authors： Suzuki H,Mori M,Seto K,Shibata F,Nagahashi S,Kawaguchi C,Suzuki M,Matsui H,Watanabe K,Miura S,Ishii H

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Pneumatic dilatation is the first line therapy in achalasia, but half of patients relapse within 5 years of therapy and require further dilatations. AIM:To assess whether botulinum toxin injection before pneumatic dilatation is superior to pneumatic dilatation alone in achalasia patients. METHODS:Newly dia...

journal_title：Alimentary pharmacology & therapeutics

authors： Mikaeli J,Bishehsari F,Montazeri G,Mahdavinia M,Yaghoobi M,Darvish-Moghadam S,Farrokhi F,Shirani S,Estakhri A,Malekzadeh R

更新日期：2006-09-15 00:00:00

abstract：BACKGROUND:In some cases, Helicobacter pylori infection persists even after three eradication treatments. AIM:To evaluate the efficacy of an empirical fourth-line rescue regimen with rifabutin in patients with three eradication failures. METHODS: DESIGN:Multicentre, prospective study. PATIENTS:In whom the following...

journal_title：Alimentary pharmacology & therapeutics

authors： Gisbert JP,Castro-Fernandez M,Perez-Aisa A,Cosme A,Molina-Infante J,Rodrigo L,Modolell I,Cabriada JL,Gisbert JL,Lamas E,Marcos E,Calvet X

更新日期：2012-04-01 00:00:00

abstract：:The pathogenesis of cholesterol gallstones is now recognized as a multifactorial process, including saturation of bile with cholesterol, destabilization of bile leading to cholesterol crystals and hypomotility permitting crystal growth, and agglomeration and retention of microstones which then grow to macroscopic gall...

journal_title：Alimentary pharmacology & therapeutics

authors： Pauletzki J,Paumgartner G

更新日期：2000-05-01 00:00:00

abstract：:Deficiency of any of the vitamins and minerals essential for normal erythropoiesis (haematinics), including iron, copper, cobalt, vitamins A, B12, B6, C, E, folic acid, riboflavin and nicotinic acid, may be associated with defective erythropoiesis and anaemia. Iron, vitamin B12 and folate are the haematinics for which...

journal_title：Alimentary pharmacology & therapeutics

authors： Pawson R,Mehta A

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Attainment of intragastric pH < 6.0 may require high-dose continuously infused proton pump therapy. AIM:To assess the pharmacokinetic and pharmacodynamic dose-responses of continuous infusion regimens of lansoprazole. METHODS:Healthy adult subjects were assigned to lansoprazole 60-mg intravenous bolus, fol...

journal_title：Alimentary pharmacology & therapeutics

authors： Howden CW,Metz DC,Hunt B,Vakily M,Kukulka M,Amer F,Samra N

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:While current medications used to treat patients with chronic hepatitis C virus (HCV) effectively produce sustained viral response (SVR), postponement of therapy is often times attributed to patient perceptions of unfavourable outcomes. However, an instrument to assess patient perceptions of therapy (i.e. tr...

journal_title：Alimentary pharmacology & therapeutics

authors： Szeinbach SL,Baran RW,Dietz B,Gazzouola Rocca L,Littlefield D,Yawn BP

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is associated with colorectal neoplasia. Yet, NAFLD ranges from simple steatosis to steatohepatitis with advanced fibrosis. AIM:To investigate the risk of colorectal neoplasia according to the presence and severity of NAFLD. METHODS:A total of 26 540 asymptomatic a...

journal_title：Alimentary pharmacology & therapeutics

authors： Ahn JS,Sinn DH,Min YW,Hong SN,Kim HS,Jung SH,Gu S,Rhee PL,Paik SW,Son HJ,Gwak GY

更新日期：2017-01-01 00:00:00

abstract：:The United Network for Organ Sharing database revealed that over the last 4-5 years, an average of 1800 patients were removed from the cadaveric waiting list annually because of patients' death and an additional 400-500 were removed from the list because of the severity of their illnesses. The pre-transplant evaluatio...

journal_title：Alimentary pharmacology & therapeutics

authors： Pham PT,Pham PC,Rastogi A,Wilkinson AH

更新日期：2005-04-15 00:00:00

abstract：BACKGROUND:Many experiments have indicated that the gut glucagons (enteroglucagons) are associated with cell proliferation in the small intestine. However, recent studies have failed to show trophic effects of glicentin (enteroglucagon) on the intestine. AIMS:To examine the effects of glicentin on intestinal prolifera...

journal_title：Alimentary pharmacology & therapeutics

authors： Sasaki M,Fitzgerald AJ,Mandir N,Sasaki K,Wright NA,Goodlad RA

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:ONO-2952 is a novel and selective inhibitor of translocator protein 18 kDa that reduces stress-induced defecation and visceral hyperalgesia in rat models. AIM:To evaluate the efficacy and safety of ONO-2952 in females with irritable bowel syndrome with diarrhoea in an exploratory proof-of-concept study. ME...

journal_title：Alimentary pharmacology & therapeutics

authors： Whitehead WE,Duffy K,Sharpe J,Nabata T,Bruce M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Lansoprazole is a new proton pump inhibitor which produces prolonged decrease of gastric acidity. The aim of this study was to compare lansoprazole to a standard dose of ranitidine in the treatment of patients with reflux oesophagitis. METHODS:Two hundred and forty-seven patients with erosive oesophagitis w...

journal_title：Alimentary pharmacology & therapeutics

authors： Robinson M,Sahba B,Avner D,Jhala N,Greski-Rose PA,Jennings DE

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:The epidemiology and pathophysiology of non-erosive gastro-oesophageal reflux disease differs from erosive gastro-oesophageal reflux disease. There is a possibility that non-erosive gastro-oesophageal reflux disease treatment requires a different regimen/approach but it is not yet acknowledged. AIM:To inves...

journal_title：Alimentary pharmacology & therapeutics

authors： Wada T,Sasaki M,Kataoka H,Tanida S,Itoh K,Ogasawara N,Oshima T,Togawa S,Kubota E,Yamada T,Mori Y,Fujita F,Ohara H,Nakao H,Sobue S,Joh T,Itoh M

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:The seroclearance of hepatitis B surface antigen (HBsAg) in patients with chronic hepatitis B (CHB) is considered to be associated with favourable clinical outcomes. AIMS:This meta-analysis was performed to establish the proportion of HBsAg loss rates among CHB patients who received combination treatment ba...

journal_title：Alimentary pharmacology & therapeutics

authors： Qiu K,Liu B,Li SY,Li H,Chen ZW,Luo AR,Peng ML,Ren H,Hu P

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Dexlansoprazole MR is a Dual Delayed Release formulation of dexlansoprazole, an enantiomer of lansoprazole, designed to extend the duration of acid suppression. AIM:To assess the 12-month safety of dexlansoprazole MR in patients with symptomatic gastro-oesophageal reflux disease (GERD). METHODS:In this ran...

journal_title：Alimentary pharmacology & therapeutics

authors： Dabholkar AH,Han C,Paris MM,Perez MC,Atkinson SN,Peura DA

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Health-related quality of life (HRQL) is often diminished in patients with ulcerative colitis. AIM:To evaluate the effects of vedolizumab on HRQL in patients with ulcerative colitis. METHODS:Using maintenance phase data from the GEMINI 1 study, an analysis of covariance model was used to calculate mean dif...

journal_title：Alimentary pharmacology & therapeutics

authors： Feagan BG,Patel H,Colombel JF,Rubin DT,James A,Mody R,Lasch K

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Ursodeoxycholic acid (UDCA) prolongs transplantation-free survival in primary biliary cirrhosis (PBC). However, the optimal therapeutic dose has not been established. AIM:To compare the effects of UDCA administered in daily doses of 10 vs. 20 mg/kg on symptoms, liver biochemistry and biliary UDCA enrichment...

journal_title：Alimentary pharmacology & therapeutics

authors： Van Hoogstraten HJ,De Smet MB,Renooij W,Breed JG,Engels LG,Den Ouden-Muller JW,Rijk MC,Smit AM,Zwertbroek R,Hop WC,van Berge Henegouwen GP,Schalm SW,van Buuren HR

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Five oral nucleos(t)ide analogues are available to treat chronic hepatitis B (CHB). With the availability of newer agents, their efficacy on incidence of hepatocellular carcinoma (HCC) is not well described. AIM:To determine the efficacy of oral anti-viral agents in reducing HCC risk in relationship with ot...

journal_title：Alimentary pharmacology & therapeutics

authors： Singal AK,Salameh H,Kuo YF,Fontana RJ

更新日期：2013-07-01 00:00:00

abstract：:We have investigated the absorption and urinary excretion of tripotassium dicitrato bismuthate during a treatment course of 4 weeks in 7 patients with normal renal function (creatinine clearance 115 +/- 29 ml/min; mean +/- S.D.), in 7 patients with impaired renal function (creatinine clearance = 34 +/- 19 ml/min) and ...

journal_title：Alimentary pharmacology & therapeutics

authors： Treiber G,Gladziwa U,Ittel TH,Walker S,Schweinsberg F,Klotz U

更新日期：1991-10-01 00:00:00

abstract：:Long-term studies have confirmed unequivocally the clinical efficacy of continuous therapy with H2-receptor antagonists in reducing the incidence of ulcer recurrence. However, studies have also reported varying relapse rates as a result of differences in study design, particularly the frequency of endoscopy and hence ...

journal_title：Alimentary pharmacology & therapeutics

authors： Dammann HG,Walter TA

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Online psychotherapy has been successfully used as supportive treatment in many chronic illnesses. However, there is a lack of evidence on its role in the management of gastrointestinal (GI) diseases. AIMS:To examine whether online psychological interventions improve mental and physical outcomes in gastroin...

journal_title：Alimentary pharmacology & therapeutics

authors： Hanlon I,Hewitt C,Bell K,Phillips A,Mikocka-Walus A

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:The various components of pain and quality of life in duodenal ulcer patients receiving antisecretory drugs have not been studied to date. METHODS:Ninety-five patients with epigastric pain and duodenal ulcer at endoscopy completed this prospective, multicenter, open-study. All were treated with effervescent...

journal_title：Alimentary pharmacology & therapeutics

authors： Rampal P,Ruszniewski P,Boureau F,Richard A,Slama A

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:In vitro studies suggest interactions between mesalazine (mesalamine) and thiopurines by thiopurine S-methyltransferase (TPMT) inhibition, influencing the balance of hepatotoxic 6-methylmercaptopurine ribonucleotide and immunosuppressive tioguanine (thioguanine) metabolites. AIM:To examine the in vivo pharm...

journal_title：Alimentary pharmacology & therapeutics

authors： Gilissen LP,Bierau J,Derijks LJ,Bos LP,Hooymans PM,van Gennip A,Stockbrügger RW,Engels LG

更新日期：2005-10-01 00:00:00