Mechanisms of leukotriene D4-induced constriction in human small bronchioles.

abstract：:1. The effect of several metabotropic ligands and di- or tripeptides were tested on the binding of [3H]-L(+)-2-amino-4-phosphonobutyric acid ([3H]-L-AP4) on rat mGlu4 receptor. For selected compounds, the functional activity was determined on this receptor using the guanosine-5'[gamma-35S]-thiotriphosphate [gamma-35S]...

journal_title：British journal of pharmacology

authors： Monastyrskaia K,Lundstrom K,Plahl D,Acuna G,Schweitzer C,Malherbe P,Mutel V

更新日期：1999-11-01 00:00:00

abstract：:1. The effects of drugs and altering stimulus parameters on neurogenic responses to electrical field stimulation (EFS) have been investigated in distal and proximal portions of the guinea-pig trachea. 2. In the presence of indomethacin (3 microM) and propranolol (1 microM) two contractile phases were evident in both t...

journal_title：British journal of pharmacology

authors： Ellis JL,Undem BJ

更新日期：1990-12-01 00:00:00

abstract：:1. We studied the inhibitory effect of pituitary adenylate cyclase activating polypeptide (PACAP 1-27) on the increase in total pulmonary resistance (RL) caused either by allergen or histamine in anaesthetized, ventilated guinea-pigs. 2. PACAP 1-27 given via i.v. infusion (0.045-4.5 nmol kg-1 min-1) dose-dependently r...

journal_title：British journal of pharmacology

authors： Lindén A,Yoshihara S,Chan B,Nadel JA

更新日期：1995-07-01 00:00:00

abstract：:1 Pretreatment of dogs for 20 to 24 h before the start of experiments with reserpine (0.5 mg/kg) depleted noradrenaline from cerebral and mesenteric arteries, the diminution being greater in the latter arteries. 2 Contractile responses of helically-cut strips of cerebral and mesenteric arteries to noradrenaline were u...

journal_title：British journal of pharmacology

authors： Hayashi S,Miyazaki M,Toda N

更新日期：1980-03-01 00:00:00

abstract：:1. The role of nitric oxide in the coronary circulation under basal conditions and when exposed to various vasodilator stimuli was studied in instrumented, anaesthetized goats, by examining the action of inhibiting endogenous nitric oxide production with NG-nitro-L-arginine methyl ester (L-NAME). 2. In 12 goats, left ...

journal_title：British journal of pharmacology

authors： García JL,Fernández N,García-Villalón AL,Monge L,Gómez B,Diéguez G

更新日期：1992-07-01 00:00:00

abstract：:1. A series of GABAB receptor antagonists were tested against (+/-)-baclofen for activity on the presynaptic GABAB receptor in the rat vas deferens. 2. All the antagonists tested caused a rightward shift in the concentration-response curve to (+/-)-baclofen. 3. pA2 values calculated from full Schild analysis were as f...

journal_title：British journal of pharmacology

authors： Hills JM,Larkin MM,Howson W

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The sodium channel is a primary target for treating central nervous system disorders such as epilepsy. In this study the anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, was evaluated in different animal models of epilepsy. EXPERIMENTAL APPROACH:Experiments were performed ...

journal_title：British journal of pharmacology

authors： Zhao R,Zhang XY,Yang J,Weng CC,Jiang LL,Zhang JW,Shu XQ,Ji YH

更新日期：2008-07-01 00:00:00

abstract：:Arthritis-associated inflammatory pain represents a serious medical problem worldwide. Current treatments for arthritic pain are not very effective and cause unwanted side effects. Resolvins, including the resolvin D and resolvin E series, are a family of novel endogenous lipid mediators derived from ω-3 polyunsaturat...

journal_title：British journal of pharmacology

authors： Xu ZZ,Ji RR

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Nitric oxide (NO) is known to activate NO-sensitive guanylyl cyclase (NO-GC) and to elicit cGMP production. However, NO has also been proposed to induce cGMP-independent effects. It is accepted practice to use specific NO-GC inhibitors, such as ODQ or NS2028, to assess cGMP-dependent NO effects. ...

journal_title：British journal of pharmacology

authors： Lies B,Groneberg D,Gambaryan S,Friebe A

更新日期：2013-09-01 00:00:00

abstract：:C-C chemokine receptor-1 (CCR1) has been implicated in mediating a variety of inflammatory conditions including multiple sclerosis and organ rejection. Although originally referred to as the MIP-1alpha/RANTES receptor, CCR1 is quite promiscuous and can be activated by numerous chemokines. We used radioligand binding a...

journal_title：British journal of pharmacology

authors： Chou CC,Fine JS,Pugliese-Sivo C,Gonsiorek W,Davies L,Deno G,Petro M,Schwarz M,Zavodny PJ,Hipkin RW

更新日期：2002-11-01 00:00:00

abstract：:1. Leptin, a pleiotropic hormone believed to regulate body weight, has recently been associated with inflammatory states and immune activity. Here we have studied the effect of leptin on expression of IFN-gamma-induced nitric oxide synthase (iNOS) and cyclo-oxygenase-2 (COX-2), both prominent markers of macrophage act...

journal_title：British journal of pharmacology

authors： Raso GM,Pacilio M,Esposito E,Coppola A,Di Carlo R,Meli R

更新日期：2002-11-01 00:00:00

abstract：:1. Inhibition of nitric oxide generation with Nw-nitro-L-arginine (nitroarginine) reduced vasodilator responses to bradykinin and acetylcholine and enhanced those to nitroprusside in the rat isolated perfused kidney, preconstricted with phenylephrine. 2. Inhibition of cyclo-oxygenase with indomethacin, decreased the v...

journal_title：British journal of pharmacology

authors： Fulton D,McGiff JC,Quilley J

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Melanin-concentrating hormone receptor 1 (MCH1 receptor) antagonists are being considered as anti-obesity agents. The present study reports a new class of MCH1 receptor antagonists with an 8-methylquinoline scaffold. The molecular mechanism of MCH1 receptor blockade by these antagonists was exami...

journal_title：British journal of pharmacology

authors： Sakurai T,Ogawa K,Ishihara Y,Kasai S,Nakayama M

更新日期：2014-03-01 00:00:00

abstract：:1. The purpose of this investigation was to determine whether enhanced contractile responses to noradrenaline (NA) of mesenteric arteries from rats with chronic streptozotocin-induced diabetes are associated with increases in mean cytosolic [Ca(2+)]i. 2. [Ca(2+)]i was measured with fura 2-AM, and was monitored simulta...

journal_title：British journal of pharmacology

authors： Chow WL,Zhang L,MacLeod KM

更新日期：2001-09-01 00:00:00

abstract：:1 About 45% of singly-housed male mice showed timidity (alert postures, running away, defensive postures) instead of aggression on interactions in pairs with group-housed male mice, though their partners did not show any aggression. The isolation-induced timidity was stable in repeated interactions. Timid mice also sh...

journal_title：British journal of pharmacology

authors： Krsiak M

更新日期：1975-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In terms of postjunctional alpha(2)-adrenoceptors in the pulmonary circulation, no evidence is available with regard to the receptor subtypes mediating vasoconstriction. Therefore, we characterized the alpha(2)-adrenoceptor subtypes mediating contraction in isolated porcine pulmonary veins. EXPE...

journal_title：British journal of pharmacology

authors： Görnemann T,von Wenckstern H,Kleuser B,Villalón CM,Centurión D,Jähnichen S,Pertz HH

更新日期：2007-05-01 00:00:00

abstract：:1 Noradrenaline and 28 imidazolidine (clonidine-like) and imidazoline (oxymetazoline-like) compounds with various phenyl ring substituents have been examined for their ability to inhibit responses to transmural stimulation and exogenous acetylcholine in ileal preparations from reserpine-treated guinea-pigs.2 The bathi...

journal_title：British journal of pharmacology

authors： Malta E,Raper C,Tawa PE

更新日期：1981-06-01 00:00:00

abstract：:1. We studied the effects of flash photolysis on the novel enantiomeric cardiac inotropes EMD 57033 (a calcium sensitizer) and EMD 57439 (a phosphodiesterase III inhibitor) in rat isolated ventricular trabeculae. 2. In skinned trabeculae, EMD 57439 had no effect on force production, consistent with lack of an active c...

journal_title：British journal of pharmacology

authors： Lee JA,Palmer S,Kentish JC

更新日期：1996-08-01 00:00:00

abstract：:The effects of N-(cyclopropylmethyl)-19-isopentylnororvinol hydrochloride (M320) on urine excretion by rats were investigated. Further studies, using rabbit isolated vas deferens, investigated its interactions with kappa-opiate receptors. The output of urine for a 2 h period after M320, administered subcutaneously to ...

journal_title：British journal of pharmacology

authors： Abrahams JM,Boura AL,Evans RG,Johnston CI,Olley JE

更新日期：1986-12-01 00:00:00

abstract：:1. Acute moderate hypoxia modifies the catalytic activity and expression of certain isoenzymes of hepatic cytochrome P450 (P450). The aim of this study was to document whether hypoxia affects hepatic P450 directly or through the release of serum mediators. 2. Rabbits were subjected to a FiO(2) of 8% for 48 h, sacrific...

journal_title：British journal of pharmacology

authors： Fradette C,Bleau AM,Pichette V,Chauret N,Du Souich P

更新日期：2002-11-01 00:00:00

abstract：:1. Intracellular recordings were made from neurones in vitro in the rat substantia nigra zona compacta and ventral tegmental area; the neurones had the characteristic properties of dopamine-containing cells, and fired action potentials spontaneously. 2. Cocaine (1-10 microM) inhibited spontaneous firing, hyperpolarize...

journal_title：British journal of pharmacology

authors： Lacey MG,Mercuri NB,North RA

更新日期：1990-04-01 00:00:00

abstract：:Melatonin deprival in young rats induces alterations in cerebral arteriolar wall similar to those observed during aging: atrophy and a decrease in distensibility. In this study, we examined the effects of melatonin treatment on cerebral arteriolar structure and distensibility and on the lower limit of cerebral blood f...

journal_title：British journal of pharmacology

authors： Dupuis F,Régrigny O,Atkinson J,Limiñana P,Delagrange P,Scalbert E,Chillon JM

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The ω-3 polyunsaturated fatty acids (PUFAs) mediate protective effects on several metabolic disorders. However, the functions of their metabolites in the early stage of nonalcoholic fatty liver disease (NAFLD) are largely unknown. EXPERIMENTAL APPROACH:Mice were fed a control diet, high-fat diet...

journal_title：British journal of pharmacology

authors： Wang C,Liu W,Yao L,Zhang X,Zhang X,Ye C,Jiang H,He J,Zhu Y,Ai D

更新日期：2017-07-01 00:00:00

abstract：:1. Carrageenin or 5-hydroxytryptamine-induced oedema of the mouse hind paw was antagonized by catecholamines acting on both alpha- and beta-adrenoceptors.2. Increased permeability of the mouse peritoneum induced by the local injection of acetic acid or pro-inflammatory mediators was antagonized by catecholamines actin...

journal_title：British journal of pharmacology

authors： Green KL

更新日期：1972-06-01 00:00:00

abstract：:Effects of hypoxia on atrioventricular conduction were investigated in the Langendorff-perfused isolated heart of the rabbit with various extracellular calcium concentrations ([Ca2+]) as well as in the presence of verapamil, nifedipine, N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7) and chlorpromazine. The ...

journal_title：British journal of pharmacology

authors： Anno T,Kodama I,Shibata S,Toyama J,Yamada K

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Oxaliplatin is a platinum-based chemotherapeutic drug used as a first-line therapy for colorectal cancer. However, its use is associated with severe gastrointestinal side-effects resulting in dose limitations and/or cessation of treatment. In this study, we tested whether oxidative stress, caused...

journal_title：British journal of pharmacology

authors： McQuade RM,Carbone SE,Stojanovska V,Rahman A,Gwynne RM,Robinson AM,Goodman CA,Bornstein JC,Nurgali K

更新日期：2016-12-01 00:00:00

abstract：:The variety of factors and events involved in neurodegeneration renders the subject a major challenge. Neurodegenerative disorders include a number of different pathological conditions, which share similar critical metabolic processes, such as protein aggregation and oxidative stress, both of which are associated with...

journal_title：British journal of pharmacology

authors： Gaeta A,Hider RC

更新日期：2005-12-01 00:00:00

abstract：:1. In order to investigate the vasodilator mechanisms of the K+ channel openers, cromakalim, pinacidil and nicorandil, we measured changes in cytoplasmic Ca2+ concentration [( Ca2+]i) simultaneously with force by a microfluorimetric method using fura-2, a calcium indicator, in canine coronary arterial smooth muscle ce...

journal_title：British journal of pharmacology

authors： Yanagisawa T,Teshigawara T,Taira N

更新日期：1990-09-01 00:00:00

abstract：:1. The mechanisms underlying the postjunctional blockade induced by phenthonium [N-(4-phenyl) phenacyl 1-hyoscyamine] were investigated in mammalian and amphibian muscles. This muscarinic antagonist was previously shown to enhance specifically the spontaneous acetylcholine (ACh) release at concentrations that blocked ...

journal_title：British journal of pharmacology

authors： Souccar C,Lima-Landman MT,Ballejo G,Lapa AJ

更新日期：1998-07-01 00:00:00

abstract：:The influence of endogenous and exogenous acidic amino acids on the binding of [3H]-MK-801, a selective, non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, has been investigated in rat cerebral cortex crude synaptic membranes (CSM). Removal of endogenous glutamate and aspartate from CSM by repeated w...

journal_title：British journal of pharmacology

authors： Foster AC,Wong EH

更新日期：1987-06-01 00:00:00