Severe glomerular sclerosis is not associated with poor outcome after kidney transplantation.

Abstract:

BACKGROUND:The increased utilization of expanded criteria kidney donors has necessitated the reevaluation of multiple donor risk factors to insure the best outcome from this valuable resource. Reports of decreased graft survival in recipients of kidneys from donors with > or =20% glomerular sclerosis (GS) have led many transplant centers to refuse these donor kidneys. The purpose of this study is to compare outcome in recipients of cadaveric donor kidneys with > or =20% GS versus those with <20% or no GS at our center. METHODS:We retrospectively reviewed 18 donor and 19 recipient and outcome variables in 89 recipients of kidneys, which were biopsied at the time of transplantation, between February 1995 and November 1998. We evaluated outcome based upon the percent of GS and the degree of vasculopathy. RESULTS:Donors with > or =20% GS were older and had more hypertension. Recipients of kidneys with > or =20% GS were older, had higher serum creatinine values at 1 and 2 years, but similar rates of delayed graft function and 2-year graft survival. Vasculopathy did not correlate to any important donor criteria except the percent GS. However, serum creatinine was significantly higher in recipients of kidneys with moderate vasculopathy versus none, up to 2 years after transplantation. There was no significant difference in graft loss based upon vasculopathy. CONCLUSION:Kidneys from donors with > or =20% GS provide excellent outcome similar to kidneys from donors with no GS.

journal_name

Am J Surg

authors

Lu AD,Desai D,Myers BD,Dafoe DC,Alfrey EJ

doi

10.1016/s0002-9610(00)00502-x

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

470-4

issue

6

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(00)00502-X

journal_volume

180

pub_type

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