Abstract:
:Radical retropubic prostatectomy (RRP) is an important cause of iatrogenic erectile dysfunction (ED). While sildenafil has been widely used since its introduction as a new treatment option for ED, its efficacy in post-RRP patients has not been extensively studied. We retrospectively compared the efficacy of sildenafil in post-RRP and non-surgical patients with ED (NSED) using a subset of questions from the International Index of Erectile Function (IIEF) and correlated results with their specific etiology of ED based on penile blood flow study (PBFS). A brief questionnaire regarding satisfaction with sildenafil was administered to 72 consecutive post-RRP patients (nerve sparing status unknown) and 32 consecutive NSED patients who had previously undergone PBFS with pharmacotesting as part of their evaluation for ED. PBFS diagnoses were arterial insufficiency (AI) for peak systolic velocity (PSV) < 25 cm/sec; venogenic (CVOD) for PSV > or = 35 cm/sec, mixed vascular for PV > 25 but < 35 cm/sec and resistive index (RI) < 0.9; a vascular normal diagnosis (neurogenic impotence) required excellent rigidity sustained for 20 min. Differences in the IIEF subscores for the different groups of patients were assessed. Success with sildenafil was defined as moderate or excellent improvement (3/4 or 4/4) with ability for penetration. No differences were found among the different subgroups of RRP patients with respect to IIEF scores or success rates with sildenafil. NSED patients had both significantly higher post-treatment IIEF scores (3.6/3.4 vs 2.5/2.2; t=4.50, P<0.0001) and success rates (63% vs 31%; t=3.11, P < 0.01) with sildenafil treatment than RRP patients. We found that sildenafil is significantly less effective in impotent RRP patients than in age-matched patients with ED (31% vs 63%). We had postulated that sildenafil would be least effective among RRP patients with excellent sustained rigidity to PGE1, as this subgroup is likely to have neurogenic impotence. We found that sildenafil response rates among subgroups of RRP patients were statistically similar regardless of PBFS diagnosis. IIEF scores for the RRP subgroups were similar but statistically lower than in men with ED and no history of RRP. While individuals with normal vascular responses to PGE1 have an increased likelihood of having neurogenic impotence, in RRP patients, we were unable to demonstrate any difference in efficacy of sildenafil, regardless of the PBFS diagnosis.
journal_name
Int J Impot Resjournal_title
International journal of impotence researchauthors
Blander DS,Sanchez-Ortiz RF,Wein AJ,Broderick GAdoi
10.1038/sj.ijir.3900525subject
Has Abstractpub_date
2000-06-01 00:00:00pages
165-8issue
3eissn
0955-9930issn
1476-5489journal_volume
12pub_type
杂志文章abstract::We evaluated the effects of chronic penile denervation on cavernous tissue morphology and function in 36 Sprague-Dawley rats. At age seven weeks, 18 animals underwent bilateral cavernous nerve neurectomy: 18 animals underwent sham operation as a control. A functional, biochemical and morphological assessment of the ra...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract::Defining the minimal clinically meaningful improvement (MCMI) is crucial to understanding the treatment effects on health-status measures. We estimated the MCMI on the quality of erection questionnaire (QEQ), a validated measure specific to assess erectile quality during sexual intercourse. Data were from two controll...
journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
doi:10.1038/ijir.2009.47
更新日期:2010-01-01 00:00:00
abstract::Hypercholesterolemia is a major risk factor for erectile dysfunction. To understand the mechanism(s) of hypercholesterolemia-induced erectile dysfunction, we studied the effect of lysophosphatidylcholine (LPC) on the membrane conductance of corporal smooth muscle cells. We used cultured human corporal smooth muscle ce...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901356
更新日期:2005-11-01 00:00:00
abstract::The objective of this study was to evaluate the effect on erections of impeding venous blood flow following intracavernosal injections of prostaglandin E1. Dispersion of injected X-ray contrast medium indicated that application of the RMRI penile clamp to the base of the penis retarded venous outflow. The clamp was th...
journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-03-01 00:00:00
abstract::Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by parkinsonism and cerebellar, autonomic, urinary, and/or pyramidal dysfunction. Urinary and erectile dysfunction (ED) symptoms are prominent early features in men with MSA. Autonomic failure, considered until recently to be the ca...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901014
更新日期:2003-08-01 00:00:00
abstract::Peyronie's disease (PD) is a condition characterized by localized and often progressive fibrosis and scarring of the penis. This condition has an unknown etiology although several hypotheses have been proposed. These include traumatic, immunologic and genetic causes. We studied the genetics and immunology of PD using ...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900591
更新日期:2000-10-01 00:00:00
abstract::Creation of a neophallus in cases of loss of the penis or female to male trans-sexual is a challenge. The forearm flap is the most popular method used. A penile implant may be placed at the original procedure or at a later date to provide support for intercourse. The hydraulic nondistally expanding types provide the b...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/sj.ijir.3901087
更新日期:2003-10-01 00:00:00
abstract::We report a rare complication of a penile prosthesis reservoir removed from the urinary bladder in a patient with a history of radiation therapy and previous abdominal surgery. The reservoir was retrieved by open cystotomy 13 years after original placement. ...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901303
更新日期:2005-05-01 00:00:00
abstract::We sought to establish the interplay of metabolic syndrome (MetS) and/or sexual dysfunction (SD) on hypogonadism. Sexual functioning was assessed using Golombok Rust Inventory of Sexual Satisfaction in 274 consecutive diabetic men visiting the diabetic clinic of the Tema General Hospital between November 2010 and Marc...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2017.6
更新日期:2017-05-01 00:00:00
abstract::To date, the effects of long-term testosterone (T) administration on the human vagina are not completely understood. Thus, the aim of this study was to investigate the effects of long-term T treatment on vaginal tissue histology, estrogen receptor alpha (ERα) and beta (ERβ) expression and proliferation in female to ma...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2013.9
更新日期:2013-09-01 00:00:00
abstract::Peyronie's disease is a common malady affecting men mostly between the ages of 40 and 60. When penile curvature and erectile softening are present and the erectile dysfunction does not respond to Viagra a penile implant will strengthen and usually straighten the penis. If curvature persists after implant placement 'mo...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900865
更新日期:2002-10-01 00:00:00
abstract::Phosphodiesterase 5 (PDE5) inhibitors are efficacious in treating patients with erectile dysfunction. New PDE5 inhibitors with different selectivity and pharmacokinetic profiles have been vigorously pursued. Here we report two novel, potent, and selective PDE5 inhibitors, JNJ-10280205 and JNJ-10287069, with Ki values ...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901462
更新日期:2006-09-01 00:00:00
abstract::In extracavernosal vascular tissue, smooth muscle tone is modulated by a balance between angiotensin II (Ang II) and nitric oxide (NO). We hypothesized that these substances also play an important role in regulating cavernosal smooth muscle contractility. We therefore studied the in vitro effects of an Ang II receptor...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900261
更新日期:1997-09-01 00:00:00
abstract::This study examined the effects of a new phosphodiesterase type 5 inhibitor, DA-8159, on erectile function associated with hypercholesterolemia. First of all, in order to investigate whether chronic administration of DA-8159 prevents the development of erectile dysfunction associated with hypercholesterolemia, male SD...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901331
更新日期:2005-09-01 00:00:00
abstract::A consecutive series of 52 men presenting with erectile dysfunction were assessed with (i) standardized sexual history, (ii) nocturnal penile tumescence and rigidity monitoring (NPTR), (iii) Rigiscan assessment of response to intracavernosal papaverine or prostaglandin injection (ICI), and (iv) duplex ultrasonography....
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::Nitric oxide (NO) is a physiologic signal essential to penile erection, and disorders that reduce NO synthesis or release in the erectile tissue are commonly associated with erectile dysfunction. NO synthase (NOS) catalyzes production of NO from L-arginine. While both constitutively expressed neuronal NOS (nNOS) and e...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/sj.ijir.3901209
更新日期:2004-06-01 00:00:00
abstract::Despite extensive research into the toxicity of bisphenol A (BPA), no report of its effect on erectile function exists. We performed this study to investigate the effect of BPA on erectile function. New Zealand white rabbits were treated intraperitoneally with 150 mg/kg of BPA every other day for 12 days (cumulative d...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900734
更新日期:2001-10-01 00:00:00
abstract::Erectile dysfunction (ED) is linked to various cardiovascular risk factors and may therefore serve as a predictor of cardiovascular events. To gain further insight into this relationship, we reviewed all data regarding hospital admission for cardial or cerebral vascular disease that occurred until 2008 in a cohort of ...
journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
doi:10.1038/ijir.2009.40
更新日期:2010-01-01 00:00:00
abstract::The purpose of this study is to investigate and compare the effects of 5-mg once-daily tadalafil versus 5-mg alternate-day tadalafil in men with moderate-to-severe erectile dysfunction (ED) and lower urinary tract symptoms (LUTS). Between January 2012 and June 2013, 144 men presenting with an International Index of Er...
journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
doi:10.1038/ijir.2014.19
更新日期:2015-01-01 00:00:00
abstract::This study was conducted to determine rate and related factors of dyspareunia. Three hundred and nineteen women aged 15-49 years were surveyed. A questionnaire was used to collect data. Pelvic examinations and connective tissue disorders were investigated. At whole 54.5% had dyspareunia. The means of gravidity, parity...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901495
更新日期:2007-01-01 00:00:00
abstract::Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) has long been used as a traditional Chinese medicine for dysfunctions of the endocrine system and inflammation conditions. However, the effect of adlay seed on the endocrine system has not yet been reported. In the present study, the effects and the mechanisms of metha...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901405
更新日期:2006-05-01 00:00:00
abstract::Apomorphine SL (TAP Holdings, Deerfield, IL) is a centrally acting treatment for erectile dysfunction (ED) that has been undergoing phase III trials. Over 3000 men have received apomorphine SL and over 75,000 doses have been taken. In the first three phase III parallel arm cross-over double-blind studies 854 patients ...
journal_title:International journal of impotence research
pub_type: 杂志文章,meta分析
doi:10.1038/sj.ijir.3900581
更新日期:2000-10-01 00:00:00
abstract::The objective was to describe funding sources and publication trends for the primary literature on Peyronie's disease (PD), including direct industry research support. A search of EMBASE, PubMed, Scopus, and Web of Science was performed to identify articles published from 2006 to 2018. Articles not published in Englis...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/s41443-020-0244-6
更新日期:2021-01-01 00:00:00
abstract::In order to assess the effectiveness of sildenafil under routine conditions of use in primary care settings and to evaluate its impact on patient's life satisfaction and partner's satisfaction with treatment for erectile dysfunction (ED), an open, multicentre, observational, prospective study was designed in which 281...
journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/sj.ijir.3900782
更新日期:2001-12-01 00:00:00
abstract::Both RigiScan and the Snap Gauge band devices are used to objectively measure penile rigidity. The Snap Gauge band is the more simple and inexpensive of the two techniques. We investigated the correlation between the results obtained by both devices in order to evaluate whether the Snap Gauge band could be employed as...
journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章
doi:10.1038/sj.ijir.3900438
更新日期:1999-12-01 00:00:00
abstract::There is strong evidence from multiple epidemological studies that lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) are correlated, independent of age or comorbidities as diabetes or hypertension. Although a direct causal relationship is not established yet, four pathophysiological mechanisms can expl...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/ijir.2011.14
更新日期:2011-05-01 00:00:00
abstract::Radical prostatectomy (RP) is a commonly performed procedure for the management of prostate cancer. While documented oncologic outcome for early stage disease is excellent, functional impairments such as incontinence and erectile dysfunction (ED) are common after the procedure. Recent evidence has implicated cavernous...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/ijir.2011.26
更新日期:2011-09-01 00:00:00
abstract::The relation between coronary artery ectasia (CAE) and erectile dysfunction (ED) has not been studied so far. Hence, we decided to investigate the erectile function score in patients with CAE. We investigated the international index of erectile function (IIEF)-5 score in 34 men with CAE, 38 men with coronary artery di...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2011.10
更新日期:2011-05-01 00:00:00
abstract::There is considerable interest in understanding the genetics of erectile dysfunction (ED). Since early twin studies that suggested a genetic component to ED, multiple candidate gene studies have identified genetic variants that may be associated with ED. Genome-wide association studies (GWAS) have overcome some of the...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/s41443-020-00372-w
更新日期:2020-11-10 00:00:00
abstract::The transient receptor potential cationic channel type A1 (TRPA1), belonging to a superfamily of cationic membrane channels, has been suggested to act as mechano- and pain sensor and, thus, to play a role in neurotransmission in the human body, including the urogenital tract. While the expression of TRPA1 has been inv...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2014.23
更新日期:2015-01-01 00:00:00