Abstract：
:Recent reports indicate that extracellular matrix and cytoskeleton plasmalemmal elements are altered in infantile hypertrophic pyloric stenosis (IHPS). Desmin is a cytoskeletal protein that is important for the organization and function of muscular fibers. It has been found to be increased in the smooth muscle in chronic intestinal pseudo-obstruction and in skeletal muscle in some forms of myopathies as well as in unexplained hypertrophic cardiomyopathies. The aim of this study was to analyze the expression of desmin in IHPS. Full-thickness muscle-biopsy specimens were obtained from 8 IHPS patients (age range 23 to 41 days) at pyloromyotomy, from 8 age-matched controls without evidence of gastrointestinal (GI) disease at autopsy, and from 2 stillborns who died at 27 and 30 weeks of gestation without evidence of GI disease. Indirect immunohistochemistry was performed using the avidin-biotin-peroxidase complex method with anti-desmin and visualized by development with 3-diaminobenzidine tetrahydrochloride. Pyloric muscle in IHPS demonstrated strong desmin immunoreactivity. The expression of desmin was also strong in the muscular layers of fetal pylorus. In the age-matched controls absent or weak desmin immunoreactivity was seen in the pyloric muscle layer. The increased amount of desmin in hypertrophied pyloric muscle in IHPS may result in inco-ordination of contraction and relaxation of the pylorus, thus causing motility dysfunction. The similar pattern of desmin expression in IHPS and fetal pylorus suggests that the organization of intermediate filaments in IHPS is in a fetal stage of development.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Guarino N,Shima H,Puri Pdoi
10.1007/s003830050745subject
Has Abstractpub_date
2000-01-01 00:00:00pages
282-4issue
4eissn
0179-0358issn
1437-9813journal_volume
16pub_type
杂志文章abstract：PURPOSE:The aim of this study was to determine if the placement of prophylactic drains influences the incidence of postoperative adverse events in neonates. METHODS:Neonatal patients undergoing laparotomy between April 2000 and December 2007 were prospectively assigned to aggressive peritoneal cavity lavage, without t...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-011-2905-5
更新日期：2011-09-01 00:00:00
abstract：:There are few publications about urolithiasis of the new born baby and infant (UNI). The UNI represents 20% of the pediatric urolithiasis. The etiologies in this age group are chiefly dominated by the urinary-tract infections and metabolic abnormalities. The purpose of this paper was to investigate the epidemiological...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-007-1889-7
更新日期：2007-04-01 00:00:00
abstract：:We report a rare case of massive haematochezia due to hookworm infestation that required two laparotomies before the cause of bleeding could be diagnosed. The need to consider this parasite as a possible cause of gut bleeding in endemic countries is stressed, as early recognition may avoid unnecessary investigations a...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF00497827
更新日期：1996-06-01 00:00:00
abstract：INTRODUCTION:Bladder Bowel Dysfunction (BBD) has been described in patients with Down's Syndrome (DS). Our aim was to report the incidence, demographics, presentation, complications and management of the bladder in DS patients with BBD. METHODS:A systematic review was performed using PRISMA guidelines and search terms...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-020-04682-4
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:The pathophysiology of Hirschsprung's disease (HSCR) is not entirely understood. There is no clear explanation for the occurrence of the spastic or tonically contracted aganglionic segment of bowel. Kv11.1 (hERG) channels play a critical role in the regulation of the resting membrane potential as well as affect...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3807-8
更新日期：2016-01-01 00:00:00
abstract：:Three cases are reported of pyogenic (non-tuberculous) myositis involving the ilio-psoas and/or iliacus muscles in children presenting to John Hunter Hospital, Newcastle, Australia, in a 12-month period. In one, cultures grew Haemophilus influenzae type B and in the other two Staphylococcus aureus was isolated. Biopsy...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF00183769
更新日期：1996-03-01 00:00:00
abstract：:An infant developed massive lower gastrointestinal haemorrhage secondary to necrotising enterocolitis after cardiac surgery. The haemorrhage was only controlled following a colectomy. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050613
更新日期：1999-07-01 00:00:00
abstract：:Gastrointestinal atresia is a major cause of bowel obstruction in the newborn. Experimental models and clinical observations have demonstrated the heterogeneous nature of its pathogenesis. A proportion is due to late intra-uterine vascular insults and some are genetic in nature. Epidemiological studies have found gast...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2138-4
更新日期：2008-06-01 00:00:00
abstract：:Congenital pyloric atresia (CPA) is a very rare condition that was first described by Calder in 1749. Commonly, CPA occurs as an isolated lesion, which has an excellent prognosis, but it can also be seen in association with other malformations, which can have a negative impact on the final outcome. The medical records...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-1903-0
更新日期：2007-06-01 00:00:00
abstract：PURPOSE:The purpose of this study was to review the clinical characteristics and prognosis of children with adrenocortical tumors (ACT). METHODS:We retrospectively reviewed the medical records of 28 patients with ACT at our hospital between March 2010 and March 2017. RESULTS:The main clinical presentations were sexua...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4409-z
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Pediatric burn injuries are one of the leading causes of preventable morbidity and mortality in Sub-Saharan Africa. Research on the complex system of social, economic and cultural factors contributing to burn injuries in this setting is much needed. METHODS:We conducted a prospective questionnaire-based ana...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3761-5
更新日期：2015-11-01 00:00:00
abstract：PURPOSE:Thoracoscopic repair can be safely performed in most types of congenital esophageal atresia (EA), including in patients with long gap EA or very low birth weight. Accordingly, we performed single- or multistage thoracoscopic repair for various EA types. We aimed to report our therapeutic strategy for thoracosco...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-019-04541-x
更新日期：2019-10-01 00:00:00
abstract：:Spontaneous prenatal closure of gastroschisis (GS) is rare and usually associated with atresia of the midgut. We describe a case of GS diagnosed at 20 weeks' gestation that resolved spontaneously in utero. At delivery the infant had an ileus. A laparotomy with a jejunocolostomy was performed, but she died at 2 months ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-002-0815-2
更新日期：2002-09-01 00:00:00
abstract：:Two infants aged 29 and 43 days, respectively, presented with a spontaneous scrotal faecal fistula from a strangulated inguinal hernia. There was associated necrotising fasciitis of the scrotum in both patients, but the testes were spared. Resection and anastomosis along with debridement of the scrotal fasciitis was s...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0754-y
更新日期：2002-09-01 00:00:00
abstract：:Antral web is a rare cause of gastric-outlet obstruction. We report a case of gastric antral web with intermittent vomiting in a 10-year-old girl who received medical treatment for 6 months. The literature on this anomaly is reviewed with respect to differential diagnosis on the basis of upper gastrointestinal radiogr...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003839900317
更新日期：2000-01-01 00:00:00
abstract：:A case of bilateral urinary tract tuberculosis presenting with acute renal failure is reported. It is believed to be the first reported instance of the disease presenting in this form. The patient was managed with preliminary high diversion followed by bilateral replacement of the ureters with ileal loops that were an...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050291
更新日期：1998-03-01 00:00:00
abstract：PURPOSE:Cervicothoracic and apical thoracic neuroblastoma pose unique surgical challenges. We report our experience with the trapdoor anterior thoracotomy (TAT) approach to overcome these difficulties. METHODS:Retrospective review of our centre's neuroblastoma database was conducted. Patients who underwent TAT at our ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-020-04692-2
更新日期：2020-08-01 00:00:00
abstract：PURPOSE:We have retrospectively evaluated all patients who underwent endoscopic puncture (EP) of ureterocele over the last 26 years with special reference to the need in the second intervention and disease-free status. METHODS:78 (69%) of the 112 patients following EP and completed follow-up were included. 51 (65%) we...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4258-9
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:This study aimed to evaluate the mid-term outcomes of single-stage modified anterior sagittal anorectoplasty (ASARP) for anorectal malformation with vestibular fistula. METHOD:Twenty-six patients with congenital imperforate anus and vestibular fistula underwent single-stage modified sphincter-saving ASARP betw...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3749-1
更新日期：2015-09-01 00:00:00
abstract：:Primary omental torsion (POT), is a rare cause of acute abdomen commonly affecting obese male adults, whereas it is extremely rare in children. In this retrospective study, we present our experience regarding the management of five children with POT and discuss the diagnostic and therapeutic implications of this entit...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-1961-3
更新日期：2007-09-01 00:00:00
abstract：:To categorize variant persistent müllerian-duct derivatives (MDD) in males and determine their related clinical presentations for further management, five male patients with retained MDDs from abnormal müllerian remnants were studied. They comprised one patient with persistent müllerian-duct syndrome, one with transve...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0718-2
更新日期：2002-09-01 00:00:00
abstract：:Children and adolescents affected by ulcerative colitis (UC) frequently require colectomy because of refractory or chronic symptoms. The aim of this paper is to present our experience and 10-year follow-up results of 28 patients who underwent endorectal pull-through (ERPT) as surgical treatment for UC, with special re...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1232-5
更新日期：2004-08-01 00:00:00
abstract：:Incarcerated inguinal hernias in infants are commonly encountered. Reduction with intravenous sedation using morphine and related drugs carries risks of apnoea and/or respiratory arrest, especially in small, ex-premature babies who have an increased incidence of incarceration and thus opiate use is best avoided. Cauda...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1534-2
更新日期：2005-09-01 00:00:00
abstract：:Eighty-three gastric transpositions for oesophageal replacement were carried out over the 15-year period 1981-1995. The vast majority of patients underwent the replacement procedure for oesophageal atresia (OA) (56), 35 following failed or abandoned attempts at primary anastomosis, and 21 for isolated atresia. Caustic...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF00178420
更新日期：1996-04-01 00:00:00
abstract：PURPOSE:Radiologically inserted gastrojejunal tubes (RGJ) and surgical jejunostomy (SJ) are established modes of jejunal feeding. The aim of the study is to review nutritional outcomes, complications and the practical consideration to enable patients and carers to make informed choice. METHODS:Retrospective review of ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4303-8
更新日期：2018-09-01 00:00:00
abstract：PURPOSE:With the widespread use of the obstetrical ultrasound, identification of a fetal suprarenal mass has become more common. Most of these masses prove to be congenital neuroblastomas (CNB), but the diagnosis is often confused with other benign lesions and the postnatal management remains to be controversial. METH...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-009-2531-7
更新日期：2010-03-01 00:00:00
abstract：INTRODUCTION:No protocol exists for prophylaxis or therapeutic management of peripherally inserted central catheter (PICC) related deep venous thrombosis (DVT) in children. Currently, very few patients are provided prophylaxis for DVT. In this study, we analyzed our current practice of PICC placement to identify the fr...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-013-3259-y
更新日期：2013-05-01 00:00:00
abstract：:Accessory hepatic tissue, unlike accessory splenic and pancreatic tissue, is rare and has a limited and almost exclusively sub diaphragmatic distribution. Fewer than ten cases of intrathoracic ectopic liver have been reported so far in the literature. This paper reports a case that caused a diagnostic dilemma. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s003830000520
更新日期：2001-07-01 00:00:00
abstract：PURPOSE:We investigated the relationship between the affected lobe and symptom onset in prenatally diagnosed congenital pulmonary airway malformation (CPAM). METHODS:53 CPAM patients diagnosed prenatally were reviewed retrospectively by creating 2 groups according to symptom onset. Group Sneo: (symptomatic during the ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-019-04460-x
更新日期：2019-05-01 00:00:00
abstract：:It is widely accepted that there are degenerative changes and decreased spermatogenesis in the contralateral descended testis (CDT) in unilateral undescended testis (UUDT). While some investigators have postulated that the mechanism may be related to primary (congenital) or secondary (autoimmune, vascular, and neural)...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830000532
更新日期：2001-07-01 00:00:00
