Synergistic sedation with low-dose midazolam and propofol for colonoscopies.

Abstract:

BACKGROUND AND STUDY AIMS:Patients undergoing colonoscopy are often sedated with benzodiazepines and long-acting opiates. Since low-dose midazolam also acts synergistically with short-acting propofol, we compared this synergistic sedation with a standard combination of midazolam and the opioid nalbuphine for colonoscopies. PATIENTS AND METHODS:A total of 79 patients presenting for colonoscopies were randomly assigned to the following protocols. Patients in group I (n = 32) received a median dose of 9 mg midazolam (interquartile range [IQR] 6 to 12); 20 patients (59%) needed additional nalbuphine (median 20 mg, IQR 10 to 20). Patients in group II (n = 47) received 2 mg midazolam and repeated injections of propofol (median 100 mg, IQR 53 to 145) with a maximal bolus of 50 mg. RESULTS:Patients treated with the synergistic sedation (group II) recovered remarkably sooner after the procedure compared with those in group I, with a median time to discharge of 17 minutes vs. 93 minutes (P<0.001). Of the patients treated with analgosedation (group I), 28 % were unable to take part in a reaction time measurement and attention awareness test 1 hour after the procedure. All patients treated with the synergistic sedation were able to participate (P=0.002), and performed better. Despite a lower proportion of complete amnesia, patients treated with synergistic sedation more often rated the procedure as comfortable (81% vs. 50 %). Quality of sedation from the point of view of the endoscopist, and cardiorespiratory parameters, were similar in both groups. CONCLUSIONS:Low-dose midazolam combined with propofol is an effective and economic alternative to benzodiazepine-based analgosedation. It is associated with a high degree of patient comfort and rapid recovery times, and has a potential cost benefit concerning nursing care and bed facilities.

journal_name

Endoscopy

journal_title

Endoscopy

authors

Reimann FM,Samson U,Derad I,Fuchs M,Schiefer B,Stange EF

doi

10.1055/s-2000-134

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

239-44

issue

3

eissn

0013-726X

issn

1438-8812

journal_volume

32

pub_type

临床试验,杂志文章,随机对照试验
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    doi:10.1055/s-2007-1021542

    authors: Kautz G

    更新日期:1983-09-01 00:00:00

  • Diagnosis of early gastric cancers in the upper part of the stomach by the endoscopic Congo red-methylene blue test.

    abstract::The clinicopathological features of the early gastric cancers in the upper part of the stomach, and the accuracy of their diagnosis by routine endoscopic examination were examined, and the accuracy of diagnosis of minute and flat cancers in the upper portion of the stomach by routine endoscopic examination and by the ...

    journal_title:Endoscopy

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    doi:10.1055/s-2007-1018556

    authors: Tatsuta M,Iishi H,Okuda S,Taniguchi H

    更新日期:1984-07-01 00:00:00

  • Esophageal varix hemorrhage and sclerotherapy--animal studies.

    abstract::Although endoscopic sclerosis for control of variceal hemorrhage is an old technique, many questions remain about the technique, its applications, and outcomes after use. This report summarizes recent data from animal studies that relate to clinical questions concerning esophageal varix hemorrhage and sclerotherapy. A...

    journal_title:Endoscopy

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-1018421

    authors: Jensen DM,Machicado GA,Silpa M

    更新日期:1986-05-01 00:00:00

  • Endoscopic ultrasound-guided bile duct access for rendezvous ERCP drainage in the setting of intradiverticular papilla.

    abstract::Cannulation of an intradiverticular papilla during endoscopic retrograde cholangiopancreatography (ERCP) can be challenging. We present here a technique for endoscopic ultrasound-guided puncture of the common bile duct followed by rendezvous ERCP for biliary drainage through the native intradiverticular papilla. ...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2005-861250

    authors: Lai R,Freeman ML

    更新日期:2005-05-01 00:00:00

  • Therapeutic pancreatic endoscopy.

    abstract::Pharmacological treatment and/or temporary pancreatic stenting can reduce the risk of pancreatitis after endoscopic retrograde cholangiopancreatography. Potential candidates are patients who are at high risk for this complication. Extensive diagnostic work-up is needed for patients with acute recurrent pancreatitis be...

    journal_title:Endoscopy

    pub_type: 杂志文章,评审

    doi:10.1055/s-2002-19391

    authors: Neuhaus H

    更新日期:2002-01-01 00:00:00

  • Morphological changes in the terminal oesophagus with varices, following sclerosis of the wall.

    abstract::Autopsies were performed on 53 patients with oesophageal varices treated with ethoxysclerol to effect sclerosis of the terminal oesophageal wall. The morphological changes after perivascular injection, disturbance of wound healing and complications are described. In 20 cases it was possible to follow the various stage...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1021692

    authors: Helpap B,Bollweg L

    更新日期:1981-11-01 00:00:00

  • Endoscopic gallstone extraction following hydrostatic balloon dilatation of stricture in the common bile duct.

    abstract::A patient with long-standing biliary complaints and a previous cholecystojejunostomy, reputed to be suffering from primary biliary cirrhosis was, on endoscopic retrograde cholangiography (ERC), found to have several large gallstones proximal to a stenosis in the common bile duct. After endoscopic papillotomy (EPT), an...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1018488

    authors: Stave R,Osnes M

    更新日期:1985-07-01 00:00:00

  • Endoscopic ultrasound guided fine needle aspiration of malignant pancreatic lesions.

    abstract:PURPOSE:To evaluate the accuracy, safety, and clinical utility of endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) of pancreatic masses. METHODS:Forty-seven patients were referred for EUS with a pancreatic mass and suspicion of pancreatic cancer based upon painless obstructive jaundice, epigastric abdom...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1004321

    authors: Bhutani MS,Hawes RH,Baron PL,Sanders-Cliette A,van Velse A,Osborne JF,Hoffman BJ

    更新日期:1997-11-01 00:00:00

  • Results of the new nitinol self-expandable stents for distal biliary structures.

    abstract:BACKGROUND AND STUDY AIMS:The nitinol stent is a self-expandable spiral stent made of nickel-titanium alloy. We performed a pilot study to evaluate the method of stent insertion and stent efficacy. PATIENTS AND METHODS:Twenty-eight patients with irresectable malignancy had nitinol stents inserted for obstructive jaund...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1005756

    authors: Smits M,Huibregtse K,Tytgat G

    更新日期:1995-09-01 00:00:00

  • Laparoscopic-endoscopic cooperative surgery for duodenal tumors: a unique procedure that helps ensure the safety of endoscopic submucosal dissection.

    abstract::A new rendezvous-style surgical technique has been developed to ensure the safety of endoscopic submucosal dissection (ESD) for duodenal tumors. The new technique, called "laparoscopic-endoscopic cooperative surgery (LECS)," combines ESD with laparoscopic, reinforcing, seromuscular suturing. This case series report de...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0034-1390909

    authors: Irino T,Nunobe S,Hiki N,Yamamoto Y,Hirasawa T,Ohashi M,Fujisaki J,Sano T,Yamaguchi T

    更新日期:2015-04-01 00:00:00

  • Efficacy and safety of endoscopic biliary lithotripsy using FREDDY laser with a radiopaque mark under fluoroscopic guidance.

    abstract::To date no clinic trials have reported on the safety and effectiveness of the use of a frequency-doubled double pulse neodymium YAG (FREDDY) laser with a radiopaque mark under fluoroscopic guidance to treat bile duct stones that are untreatable by conventional endoscopic therapy. We report the cases of 30 patients wit...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0030-1256555

    authors: Liu F,Jin ZD,Zou DW,Li ZS

    更新日期:2011-10-01 00:00:00

  • Endoscopic full-thickness resection (eFTR) of colorectal lesions: results from the Dutch colorectal eFTR registry.

    abstract:BACKGROUND:Endoscopic full-thickness resection (eFTR) is a minimally invasive resection technique that allows definite diagnosis and treatment for complex colorectal lesions ≤ 30 mm unsuitable for conventional endoscopic resection. This study reports clinical outcomes from the Dutch colorectal eFTR registry. METHODS:C...

    journal_title:Endoscopy

    pub_type: 临床试验,杂志文章

    doi:10.1055/a-1176-1107

    authors: Zwager LW,Bastiaansen BAJ,Bronzwaer MES,van der Spek BW,Heine GDN,Haasnoot KJC,van der Sluis H,Perk LE,Boonstra JJ,Rietdijk ST,Wolters HJ,Weusten BLAM,Gilissen LPL,Ten Hove WR,Nagengast WB,Bekkering FC,Schwartz MP,Terha

    更新日期:2020-11-01 00:00:00

  • Evaluation of bipolar radiofrequency ablation for occluded self-expandable metal stents in the bile duct: in vivo and in vitro study.

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    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0034-1392252

    authors: Yoon WJ,Kim YT,Daglilar ES,Mino-Kenudson M,Brugge WR

    更新日期:2015-12-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1055/s-1999-146

    authors: Tassios PS,Ladas SD,Grammenos I,Demertzis K,Raptis SA

    更新日期:1999-11-01 00:00:00

  • Acceptability of two colorectal cancer screening tests: pain as a key determinant in sigmoidoscopy.

    abstract::Background Participants' experience with a screening test can influence adherence, and therefore the efficacy of screening programs. We compared screening with unsedated flexible sigmoidoscopy and fecal immunochemical testing (FIT) for participants' satisfaction with the decision and for willingness to repeat colorect...

    journal_title:Endoscopy

    pub_type: 杂志文章,随机对照试验

    doi:10.1055/s-0043-117400

    authors: Kirkøen B,Berstad P,Botteri E,Dalén E,Nilsen JA,Hoff G,de Lange T,Bernklev T

    更新日期:2017-11-01 00:00:00

  • The costs of colonoscopy in patients with ulcerative pan-colitis in Sweden.

    abstract::The costs of colonoscopy examinations at a hospital in Sweden were calculated in ten consecutive patients with ulcerative pan-colitis. Since colonoscopy in such patients is incomplete if not followed by microscopic study of the state of the colon mucosa, the costs of both the endoscopic and histological examinations w...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1008948

    authors: Rubio CA,Slezak P,Befrits R

    更新日期:1994-02-01 00:00:00

  • Endoscopic microsurgery of rectal tumors.

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    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1018307

    authors: Buess G,Kipfmüller K,Naruhn M,Braunstein S,Junginger T

    更新日期:1987-11-01 00:00:00

  • Prospective multicenter quality assessment of endotherapy of biliary stones: does center volume matter?

    abstract:BACKGROUND AND STUDY AIMS:To study the effectiveness of endoscopic treatment for biliary stones in a large case list of patients treated in units with different experience and different workloads in a region of northern Italy. PATIENTS AND METHODS:We prospectively studied 700 patients undergoing endoscopic retrograde ...

    journal_title:Endoscopy

    pub_type: 杂志文章,多中心研究

    doi:10.1055/s-2007-966934

    authors: Masci E,Minoli G,Rossi M,Terruzzi V,Comin U,Ravelli P,Buffoli F,Lomazzi A,Dinelli M,Prada A,Zambelli A,Fesce E,Lella F,Fasoli R,Perego EM,Colombo E,Bianchi G,Testoni PA

    更新日期:2007-12-01 00:00:00

  • Lithotripsy of urinary concrement in the sigmoid after ureterosigmoidostomy.

    abstract::A urinary concrement which appeared in the sigmoid of a 63-year-old man after ureterosigmoidostomy was extracted by endoscopy. The stone was situated proximal to a radiogenic stenosis. Because of the disproportion between the stone and the sigmoidal stenosis, mechanical lithotripsy had to be done before the concrement...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1018453

    authors: Burmeister W,Windthorst M,Wurbs D

    更新日期:1985-01-01 00:00:00

  • Prevalence of Helicobacter pylori antibodies in the serum of gastroenterologists in Austria.

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    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1009067

    authors: Pristautz H,Eherer A,Brezinschek R,Truschnig-Wilders M,Petritsch W,Schreiber F,Hammer HF,Wenzl H,Hinterleitner T,Reicht G

    更新日期:1994-10-01 00:00:00

  • Gallstone ileus revealed by endoscopy.

    abstract::Report on a female patient withe intestinal obstruction which endoscopically showed two radiolucent gallstones visualized by radiological examination of the duodenum with barium and removed through a gastrotomy. ...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0028-1098500

    authors: Tauris P

    更新日期:1977-05-01 00:00:00

  • Narrow-band imaging with magnification in Barrett's esophagus: validation of a simplified grading system of mucosal morphology patterns against histology.

    abstract:BACKGROUND AND STUDY AIMS:Validation of a simplified classification of mucosal morphology in prediction of histology in Barrett's esophagus using narrow-band imaging with magnification (NBI-Z) and assessing its reproducibility by endoscopists experienced in the use of NBI (NBI-experts) and by endoscopists who were new ...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-995741

    authors: Singh R,Anagnostopoulos GK,Yao K,Karageorgiou H,Fortun PJ,Shonde A,Garsed K,Kaye PV,Hawkey CJ,Ragunath K

    更新日期:2008-06-01 00:00:00

  • A modified sclerosing needle for the sclerotherapy of upper gastrointestinal bleeding.

    abstract::A modified instrument that permits simultaneous endoscopic irrigation and sclerotherapy of a bleeding site in the gastrointestinal tract under direct visualisation is presented. To date, the system has been used in 12 patients. Five cases of grade III esophageal varices have been treated and in three cases of acute bl...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1018508

    authors: Reis HE,Korsten FW

    更新日期:1985-11-01 00:00:00

  • Inflammatory bowel disease.

    abstract::Significant advances have been made in our understanding of the etiology of inflammatory bowel diseases, particularly with the identification of the first gene mutation associated with Crohn's disease; the treatment arsenal has also been expanded, and some new developments have been seen with regard to diagnosis as we...

    journal_title:Endoscopy

    pub_type: 杂志文章,评审

    doi:10.1055/s-2003-37019

    authors: Schölmerich J

    更新日期:2003-02-01 00:00:00

  • Endocytoscopy is a promising modality with high diagnostic accuracy for gastric cancer.

    abstract:BACKGROUND AND STUDY AIM:Endocytoscopy (ECS) enables in vivo microscopic imaging, which allows analysis of mucosal structures at the cellular level; however, limited data are available on the validity of ECS in the stomach. The aim of this study was to evaluate the feasibility of ECS in the diagnosis of early gastric c...

    journal_title:Endoscopy

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-0034-1377965

    authors: Kaise M,Ohkura Y,Iizuka T,Kimura R,Nomura K,Kuribayashi Y,Yamada A,Yamashita S,Furuhata T,Kikuchi D,Ogawa O,Matsui A,Mitani T,Hoteya S

    更新日期:2015-01-01 00:00:00

  • A new system for rapid large-caliber percutaneous transhepatic drainage in patients with obstructive jaundice: a prospective randomized trial.

    abstract:UNLABELLED:BACKGROUND AND STUDY, AIMS: Percutaneous access to the biliary tract is an important diagnostic and therapeutic tool in the management of biliary diseases. It is usually chosen when the endoscopic approach via endoscopic retrograde cholangiopancreatography (ERCP) fails, or is not possible. Once established, ...

    journal_title:Endoscopy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1055/s-2001-12814

    authors: Frimberger E,Vente T,Wagenpfeil S,Gerein P,Born P,Fritz N,Allescher HD,Ott R,Weigert N,Classen M,Rösch T

    更新日期:2001-03-01 00:00:00

  • Endoscopic markers of villous atrophy are not useful for the detection of celiac disease in patients with dyspeptic symptoms.

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    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2006-925373

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    更新日期:2006-07-01 00:00:00

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    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-1999-13659

    authors: Trap R,Adamsen S,Hart-Hansen O,Henriksen M

    更新日期:1999-02-01 00:00:00

  • Higher adenoma detection rate with the endocuff: a randomized trial.

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    journal_title:Endoscopy

    pub_type: 杂志文章,随机对照试验

    doi:10.1055/s-0043-117879

    authors: González-Fernández C,García-Rangel D,Aguilar-Olivos NE,Barreto-Zúñiga R,Romano-Munive AF,Grajales-Figueroa G,Zamora-Nava LE,Téllez-Avila FI

    更新日期:2017-11-01 00:00:00

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    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/a-1284-5891

    authors: Eluri S,Corder SR,Kim E,Tappata M,Reed CC,Shaheen NJ,Dellon ES

    更新日期:2020-10-06 00:00:00