Endoscopic markers of villous atrophy are not useful for the detection of celiac disease in patients with dyspeptic symptoms.

Abstract:

BACKGROUND AND STUDY AIMS:Celiac disease can manifest with nonspecific symptoms, including functional gastrointestinal disorders such as dyspepsia. The aim of our study was to assess the usefulness of duodenal endoscopic markers of villous atrophy for the selection of dyspeptic patients for histological assessment. PATIENTS AND METHODS:Esophagogastroduodenoscopy was performed in dyspeptic patients, in patients considered to be at risk of having celiac disease, and in healthy controls. At least three duodenal biopsies were performed for histological assessment of villous atrophy in all patients and controls. We looked for the following four duodenal endoscopic markers of celiac disease: reduction in the number of folds, scalloping of folds, mosaic-pattern mucosa, and nodular mucosa. RESULTS:A total of 175 people were enrolled (75 patients with dyspepsia; 75 patients who were "at risk" of having celiac disease; and 25 healthy volunteers, or "controls"). Of the dyspeptic patients, four had endoscopic markers of celiac disease with no histologically confirmed villous atrophy, while one patient without endoscopic markers was found to have Marsh type I villous atrophy. Of the patients at risk of having celiac disease, 16 had at least one endoscopic marker and 10/16 were found to have histological villous atrophy. In this group, the sensitivity and specificity of the endoscopic markers were 100 % and 90.8 % respectively. "At-risk" patients with two or more endoscopic markers all had histologically confirmed villous atrophy. Neither endoscopic markers nor villous atrophy were found in any of the control patients. CONCLUSIONS:Additional endoscopic markers are valuable for diagnosis in patients with clinical symptoms suggestive of celiac disease. In contrast, endoscopic markers of villous atrophy are not useful for selecting a subgroup of dyspeptic patients for screening for celiac disease by duodenal histological assessment. These patients should be screened using other protocols.

journal_name

Endoscopy

journal_title

Endoscopy

authors

Lecleire S,Di Fiore F,Antonietti M,Savoye G,Lemoine F,Le Pessot F,Lerebours E,Ducrotté P

doi

10.1055/s-2006-925373

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

696-701

issue

7

eissn

0013-726X

issn

1438-8812

journal_volume

38

pub_type

杂志文章
  • Endotoxemia and mediator release during colonoscopy.

    abstract:BACKGROUND AND STUDY AIMS:Previous clinical and experimental studies have shown evidence of a leakage of whole bacteria and bacterial products after major trauma through the gut barrier. By determining plasma endotoxin levels, products of the arachidonic pathway, interleukin-6, and the endotoxin-neutralizing capacity (...

    journal_title:Endoscopy

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-2007-1005785

    authors: Berger D,Boelke E,Stanescu A,Buttenschoen K,Vasilescu C,Seidelmann M,Beger HG

    更新日期:1995-11-01 00:00:00

  • "Candy cane" syndrome: a report of a mini-invasive endoscopic treatment using OverStitch, a novel endoluminal suturing system.

    abstract:: ...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/a-0756-8304

    authors: Granata A,Cicchese N,Amata M,De Monte L,Bertani A,Ligresti D,Traina M

    更新日期:2019-01-01 00:00:00

  • Secondary sclerosing cholangitis after long-term treatment in an intensive care unit: clinical presentation, endoscopic findings, treatment, and follow-up.

    abstract:BACKGROUND AND STUDY AIMS:We present ten patients who developed secondary sclerosing cholangitis following long-term treatment in an intensive care unit (ICU) between 1999 and 2004. PATIENTS AND METHODS:Ten consecutive patients who had no evidence suggestive of pre-existing hepatobiliary disease were admitted to an IC...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2006-925241

    authors: Jaeger C,Mayer G,Henrich R,Gossner L,Rabenstein T,May A,Guenter E,Ell C

    更新日期:2006-07-01 00:00:00

  • Laser-induced shockwave lithotripsy of gallstones.

    abstract::With the aid of a Q-switched Nd:YAG laser with energy transmission via a flexible glass fiber, it proves possible under laboratory conditions, to destroy gallstones reliably and reproducibly. Lithotripsy is effected mechanically via a laser-induced local shockwave. ...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1018340

    authors: Ell C,Wondrazek F,Frank F,Hochberger J,Lux G,Demling L

    更新日期:1986-05-01 00:00:00

  • The spiral enteroscopy training initiative: results of a prospective study evaluating the Discovery SB overtube device during small bowel enteroscopy (with video).

    abstract:BACKGROUND AND AIM:Indications for small-bowel enteroscopy are increasing, but advancing the endoscope to the ileum remains challenging, especially for less experienced operators. The aim was to evaluate the ease of use, safety, and efficacy of the Discovery SB overtube (Spirus Medical, Stoughton, Massachusetts, USA) d...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0028-1119602

    authors: Buscaglia JM,Dunbar KB,Okolo PI 3rd,Judah J,Akerman PA,Cantero D,Draganov PV

    更新日期:2009-03-01 00:00:00

  • Effect of drug-eluting metal stents in benign esophageal stricture: an in vivo animal study.

    abstract:BACKGROUND AND STUDY AIMS:The aim of this study in canines was to investigate the effectiveness and safety of self-expandable metal stents, which were coated with paclitaxel to minimize the tissue response. MATERIALS AND METHODS:14 dogs (5-10 kg) were randomly allocated to two groups. Drug-eluting stents (DES, n = 7) ...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0029-1214607

    authors: Jeon SR,Eun SH,Shim CS,Ryu CB,Kim JO,Cho JY,Lee JS,Lee MS,Jin SY

    更新日期:2009-05-01 00:00:00

  • Treatment of biliary obstruction in selected patients by endoscopic ultrasonography (EUS)-guided transluminal biliary drainage.

    abstract:BACKGROUND AND STUDY AIMS:Endoscopic retrograde cholangiopancreatography (ERCP)-guided implantation of a biliary endoprosthesis or stent is the gold standard treatment for biliary obstructions. When the papilla cannot be traversed because there is pyloric or duodenal stenosis, or the catheter cannot be introduced, or b...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-966215

    authors: Will U,Thieme A,Fueldner F,Gerlach R,Wanzar I,Meyer F

    更新日期:2007-04-01 00:00:00

  • Diagnosis of esophagogastric tumors.

    abstract::The incidence of esophageal tumors, and of adenocarcinoma in particular, has risen markedly in recent years in the developed countries. The use of a variety of histopathological and biological markers is now offering promising prospects for the future. Vertical tumor invasion, intratumoral microvessel density, antimuc...

    journal_title:Endoscopy

    pub_type: 杂志文章,评审

    doi:10.1055/s-2001-11182

    authors: Moretó M

    更新日期:2001-01-01 00:00:00

  • Heterotopic gastric mucosa in the rectum.

    abstract::A case of an ulcer of the rectum in a 20-year-old patient with rectal pain and rectal bleeding is reported. Histological examination of the endoscopic biopsy showed the presence of gastric or fundic mucosa. The patient was treated with Cimetidine and alkaline drugs, with positive results. Ulcer cicatrization was verif...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1013008

    authors: Castellanos D,Menchen P,López de la Riva M,Clemente G,Senen M,Rabago L,Garcia Andrade M,Alcalá-Santaella R

    更新日期:1984-09-01 00:00:00

  • Effectiveness of the Ultraflex Diamond stent for the palliation of malignant biliary obstruction.

    abstract:BACKGROUND AND STUDY AIMS:Endoscopically placed metallic biliary stents provide durable drainage for malignant biliary obstruction. The best-studied metal stent is the Wallstent, which has a greater duration of patency than polyethylene stents. Recently, the Ultraflex Diamond stent has been introduced, with reports fro...

    journal_title:Endoscopy

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-2002-34269

    authors: Ahmad J,Siqueira E,Martin J,Slivka A

    更新日期:2002-10-01 00:00:00

  • Endoscopic mucosal resection.

    abstract::We are now finding more malignancies in their early stages than previously. Attempts to ablate these lesions are difficult and do not provide the histological information required to decide on further treatment. Surgery is difficult to justify, as only a minority of lesions are associated with lymph node metastases an...

    journal_title:Endoscopy

    pub_type: 杂志文章,评审

    doi:10.1055/s-2001-16224

    authors: Rembacken BJ,Gotoda T,Fujii T,Axon AT

    更新日期:2001-08-01 00:00:00

  • Complications in and performance of double-balloon enteroscopy (DBE): results from a large prospective DBE database in Germany.

    abstract:BACKGROUND AND STUDY AIMS:Double-balloon enteroscopy (DBE) has been established as an invaluable tool for the diagnosis and treatment of small-bowel diseases. To evaluate complications, procedural data, and diagnostic yield of DBE examinations in Germany the presented database was introduced. METHODS:A prospective dat...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0030-1256249

    authors: Möschler O,May A,Müller MK,Ell C,German DBE Study Group.

    更新日期:2011-06-01 00:00:00

  • Needle-knife sphincterotomy guided by a biliary endoprosthesis in Billroth II gastrectomy patients.

    abstract:BACKGROUND AND STUDY AIMS:All available techniques for performing endoscopic sphincterotomy in Billroth II gastrectomy patients have their limitations, and no standard technique has emerged. A new technique, needle-knife sphincterotomy guided by a thin (7 Fr) biliary endoprosthesis, is described here that overcomes som...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1005676

    authors: van Buuren HR,Boender J,Nix GA,van Blankenstein M

    更新日期:1995-03-01 00:00:00

  • Endoscopy-assisted emergency treatment of gastroduodenal and pancreatobiliary ascariasis.

    abstract::Five patients with gastrointestinal tract and pancreatobiliary ascariasis presenting as emergency cases are reported here. Two patients presented with hematemesis due to gastric ascariasis, one with abdominal pain due to duodenal ascariasis, and one each with biliary and pancreatic ascariasis manifesting as acute chol...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1005560

    authors: Misra SP,Dwivedi M

    更新日期:1996-09-01 00:00:00

  • Efficacy of total colonoscopy with a transparent cap in comparison with colonoscopy without the cap.

    abstract:BACKGROUND AND STUDY AIMS:In spite of scrupulous inspection during routine colonoscopy, small lesions behind the semilunar folds can be situated in blind spots, where they are easily overlooked. The aim of this study was to evaluate the efficacy of total colonoscopy with a transparent cap in identifying such lesions, i...

    journal_title:Endoscopy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1055/s-2007-1001305

    authors: Matsushita M,Hajiro K,Okazaki K,Takakuwa H,Tominaga M

    更新日期:1998-06-01 00:00:00

  • Endoscopic treatment of scar stenosis in the upper GI tract.

    abstract::Short cicatricial stenoses following surgery of the upper gastrointestinal tract are difficult to treat and have a high recurrence rate. A method of eliminating stenoses endoscopically with the aid of diathermy is described. This method has, to date, been employed in 51 patients, and only a single serious complication...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1018571

    authors: Groitl H

    更新日期:1984-09-01 00:00:00

  • Endoscopic closure of postoperative esophageal leaks with a novel over-the-scope clip system.

    abstract::Management of esophageal anastomotic leaks is associated with high morbidity and mortality and remains an interdisciplinary challenge. We describe the first two cases of endoscopic closure of postoperative leaks following gastrectomy and primary repair after spontaneous acute esophageal perforation, using the over-the...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0030-1255634

    authors: Pohl J,Borgulya M,Lorenz D,Ell C

    更新日期:2010-09-01 00:00:00

  • Transendoscopic Doppler ultrasound: usefulness for diagnosis and treatment of vascular malformations.

    abstract::Vascular malformations of the GI tract can be treated by thermal methods, including the YAG laser. The diagnosis of these lesions is not always easy, and it is difficult to evaluate the completeness of therapy of these lesions. We investigated the value of Doppler ultrasound in this respect. The TVD-1 (Key Med) transe...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1018146

    authors: Rutgeerts P,Vantrappen G,D'Heygere F,Broeckaert L

    更新日期:1988-05-01 00:00:00

  • A clinicopathological study of minute polypoid lesions of the colon based on magnifying fiber-colonoscopy and dissecting microscopy.

    abstract::Magnifying fiber-colonoscopy reveals that adenoma, minute carcinomatous lesion in an adenoma (which is termed focal carcinoma), and mucosal carcinoma of the colon, each has its own characteristic pit pattern. Inspection by dissecting microscope of resected specimens obtained from subjects whose colonic mucosa had been...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1021727

    authors: Nishizawa M,Okada T,Sato F,Kariya A,Mayama S,Nakamura K

    更新日期:1980-05-01 00:00:00

  • Endoscopic vs. laparoscopic gastrojejunostomy for duodenal obstruction: a randomized study in a porcine model.

    abstract:BACKGROUND AND STUDY AIMS:Open or laparoscopic gastrojejunostomy is an established treatment for malignant duodenal obstruction but may be associated with significant morbidity and mortality. The purpose of this study was to develop a model for an entirely endoscopic gastrojejunostomy to treat duodenal obstruction, and...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0031-1291447

    authors: von Renteln D,Vassiliou MC,McKenna D,Suriawinata AA,Swain CP,Rothstein RI

    更新日期:2012-02-01 00:00:00

  • Endoscopic ultrasound-guided bilioduodenal anastomosis: a new technique for biliary drainage.

    abstract::Endoscopic biliary stenting is the most common method of treating obstructive jaundice. We present a new technique of biliary drainage using endoscopic ultrasound (EUS) and EUS-guided puncture of the common bile duct (CBD). A 56-year-old man with obstructive jaundice was referred for EUS and endoscopic retrograde chol...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2001-17324

    authors: Giovannini M,Moutardier V,Pesenti C,Bories E,Lelong B,Delpero JR

    更新日期:2001-10-01 00:00:00

  • Surveillance colonoscopy and biopsy in patients with ureterosigmoidostomy.

    abstract::Colonoscopy with biopsy was included in the surveillance of 19 patients with ureterosigmoidostomy, because of the high incidence of colonic carcinoma reported in such cases. The patients were examined 1-6 times, at intervals of 1-2 years, 4-36 years after the urinary diversion. Random biopsies from the distal colon an...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2007-1018236

    authors: Berg NO,Fredlund P,Månsson W,Olsson SA

    更新日期:1987-03-01 00:00:00

  • Diagnosis and management of iatrogenic endoscopic perforations: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement - Update 2020.

    abstract::1:  ESGE recommends that each center implements a written policy regarding the management of iatrogenic perforations, including the definition of procedures that carry a higher risk of this complication. This policy should be shared with the radiologists and surgeons at each center. 2 : ESGE recommends that in the cas...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/a-1222-3191

    authors: Paspatis GA,Arvanitakis M,Dumonceau JM,Barthet M,Saunders B,Turino SY,Dhillon A,Fragaki M,Gonzalez JM,Repici A,van Wanrooij RLJ,van Hooft JE

    更新日期:2020-09-01 00:00:00

  • Peroral endoscopic myotomy and peroral endoscopic pyloromyotomy as a single procedure for concomitant achalasia and gastroparesis.

    abstract:: ...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/a-0658-5691

    authors: Erhartova D,Vackova Z,Hustak R,Spicak J,Martinek J

    更新日期:2018-12-01 00:00:00

  • Overcoming the barriers to dissemination and implementation of quality measures for gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) and United European Gastroenterology (UEG) position statement.

    abstract::The European Society of Gastrointestinal Endoscopy (ESGE) has developed performance measures and established a framework for quality assessment for gastrointestinal endoscopy in Europe. Most national societies actively undertake initiatives to implement and explicitly endorse these quality indicators. Given this, ESGE...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/a-1312-6389

    authors: Bisschops R,Rutter MD,Areia M,Spada C,Domagk D,Kaminski MF,Veitch A,Khannoussi W,Gralnek IM,Hassan C,Messmann H,Ponchon T,Fockens P,Dignass A,Dinis-Ribeiro M

    更新日期:2021-02-01 00:00:00

  • Laparoscopic repair of paraesophageal hernia.

    abstract:BACKGROUND AND STUDY AIMS:Surgical repair of paraesophageal hernia is mandatory, due to the risk of severe complications, and it can be accomplished via the laparoscopic route. This study presents the results of laparoscopic repair of paraesophageal hernia combined with anterior hemifundoplication. PATIENTS AND METHOD...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2001-15306

    authors: Athanasakis H,Tzortzinis A,Tsiaoussis J,Vassilakis JS,Xynos E

    更新日期:2001-07-01 00:00:00

  • Detachable snare versus epinephrine injection in the prevention of postpolypectomy bleeding: a randomized and controlled study.

    abstract:BACKGROUND AND STUDY AIMS:Several endoscopic techniques have been developed to prevent bleeding after the removal of large pedunculated polyps. PATIENTS AND METHODS:From January 1995 to December 2002, 488 consecutive patients with pedunculated colorectal polyps, the heads of which were larger than 10 mm in diameter, w...

    journal_title:Endoscopy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1055/s-2004-825801

    authors: Di Giorgio P,De Luca L,Calcagno G,Rivellini G,Mandato M,De Luca B

    更新日期:2004-10-01 00:00:00

  • Ulcerative colitis in a patient with Wiskott-Aldrich syndrome.

    abstract::A 30-year-old man with underlying Wiskott-Aldrich syndrome, which is a rare X-linked congenital immunodeficiency syndrome characterized by recurrent infections, thrombopenia, eczema and hematopoietic malignancies, presented with bloody diarrhea. Endoscopic and histological evaluation was compatible with ulcerative col...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2002-34272

    authors: Folwaczny C,Ruelfs C,Walther J,König A,Emmerich B

    更新日期:2002-10-01 00:00:00

  • Endoscopic submucosal dissection for superficial rectal tumors: prospective evaluation in France.

    abstract:BACKGROUND AND STUDY AIMS:Endoscopic submucosal dissection (ESD) provides a high en bloc resection rate for superficial colorectal tumors. The aims of this study were to assess the feasibility of ESD in France and to evaluate the complete resection rate at 1 year. PATIENTS AND METHODS:Patients with superficial rectal ...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-0034-1365810

    authors: Rahmi G,Hotayt B,Chaussade S,Lepilliez V,Giovannini M,Coumaros D,Charachon A,Cholet F,Laquière A,Samaha E,Prat F,Ponchon T,Bories E,Robaszkiewicz M,Boustière C,Cellier C

    更新日期:2014-08-01 00:00:00

  • High-resolution magnification endoscopy can reliably identify normal gastric mucosa, Helicobacter pylori-associated gastritis, and gastric atrophy.

    abstract:BACKGROUND AND STUDY AIMS:The aims of the study were to describe the magnified endoscopic findings in the gastric body, correlate these with histology, and evaluate their reproducibility in the assessment of the magnified endoscopic patterns seen. PATIENTS AND METHODS:A total of 95 consecutive dyspeptic patients under...

    journal_title:Endoscopy

    pub_type: 杂志文章

    doi:10.1055/s-2006-945056

    authors: Anagnostopoulos GK,Yao K,Kaye P,Fogden E,Fortun P,Shonde A,Foley S,Sunil S,Atherton JJ,Hawkey C,Ragunath K

    更新日期:2007-03-01 00:00:00