Abstract:
:The removal of chlorofluorocarbon (CFC) propellants from industrial and household products has been agreed to by over 165 countries of which more than 135 are developing countries. The timetable for this process is outlined in the Montreal Protocol on Substances that Deplete the Ozone Layer document and in several subsequent amendments. Pressured metered dose inhalers (pMDIs) for medical use have been granted temporary exemptions until replacement formulations, providing the same medication via the same route, and with the same efficacy and safety profiles, are approved for human use. Hydrofluoroalkanes (HFAs) are the alternative propellants for CFCs-12 and -114. Their potential for damage to the ozone layer is nonexistent, and while they are greenhouse gases, their global warming potential is a fraction (one-tenth) of that of CFCs. Replacement formulations for almost all inhalant respiratory medications have been or are being produced and tested; in Canada, it is anticipated that the transition to these HFA or CFC-free pMDIs will be complete by the year 2005. Initially, an HFA pMDI was to be equivalent to the CFC pMDI being replaced, in terms of aerosol properties and effective clinical dose. However, this will not necessarily be the situation, particularly for some corticosteroid products. Currently, only one CFC-free formulation is available in Canada - Airomir, a HFA salbutamol pMDI. This paper discusses the in vitro aerosol characteristics, in vivo deposition and clinical data for several HFA pMDIs for which there are data available in the literature. Alternative delivery systems to the pMDI, namely, dry powder inhalers and nebulizers, are briefly reviewed.
journal_name
Can Respir Jjournal_title
Canadian respiratory journalauthors
Dolovich Mdoi
10.1155/1999/682405subject
Has Abstractpub_date
1999-05-01 00:00:00pages
290-5issue
3eissn
1198-2241issn
1916-7245journal_volume
6pub_type
杂志文章,评审abstract:BACKGROUND:Intravenous epoprostenol, a prostaglandin analogue, has been a mainstay of therapy for patients with advanced pulmonary arterial hypertension (PAH) since the early 1990s. This medication has multiple side effects, and sudden discontinuation is potentially associated with severe sequelae. Several recent case ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:10.1155/2011/104834
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:The authors have previously reported an increased prevalence of asthma in Estevan, Saskatchewan (21.4%) compared with Swift Current, Saskatchewan (16.2%). OBJECTIVE:To determine the association between asthma and personal and indoor environmental risk factors in these communities. METHODS:A population-base...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2005/942637
更新日期:2005-09-01 00:00:00
abstract::Endemic tuberculosis (TB) was almost certainly present in Canadian aboriginal people (aboriginal Canadians denotes status Indians, Inuit, nonstatus Indians and metis as reported by Statistics Canada) before the Old World traders arrived. However, the social changes that resulted from contact with these traders created...
journal_title:Canadian respiratory journal
pub_type: 历史文章,杂志文章,评审
doi:10.1155/2000/498409
更新日期:2000-03-01 00:00:00
abstract::Background. Mild obstructive sleep apnea is common in pregnancy and may have an exacerbating role in gestational hypertension, although currently the interaction between these two diseases is uncertain. Methods. We analyzed 43 pregnant subjects, 28 with gestational hypertension (GH) and 15 with normal healthy pregnanc...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2016/9816494
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Surgical resection for acute necrotizing lung infections is not widely accepted due to unclear indications and high risk. OBJECTIVE:To review results of resection in the setting of acute necrotizing lung infections. METHODS:A retrospective review of patients who underwent parenchymal resection between Janu...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2006/760390
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Pulmonary hypertension (PH) in patients with connective tissue disease (CTD) can occur in isolation or concomitantly with interstitial lung disease (ILD). Targeted therapies for PH can mitigate clinical deterioration in CTD patients with isolated PH; however, the effect of these therapies in CTD patients wit...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2010/686098
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Patients with chronic obstructive pulmonary disease (COPD) and asthma depend on inhalers for management, but critical errors committed during inhaler use can limit drug effectiveness. Outpatient education in inhaler technique remains inconsistent due to limited resources and inadequate provider knowledge. O...
journal_title:Canadian respiratory journal
pub_type: 临床试验,杂志文章
doi:10.1155/2015/731357
更新日期:2015-09-01 00:00:00
abstract::A 3.5-week-old male neonate who developed an upper and lower respiratory tract rhinovirus infection that was temporally associated with the development of severe pulmonary hypertension is described. Rhinovirus has not previously been associated with pulmonary hypertension. This child developed severe pulmonary hyperte...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2012/826874
更新日期:2012-01-01 00:00:00
abstract::Pulmonary arteritis is a rare cause of pulmonary hypertension. Causes of pulmonary arteritis can be divided into primary and secondary, as well as classified according to vessel size. Only large vessel vasculitis is associated with pulmonary hypertension; primary forms include Takayasu arteritis and giant cell arterit...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2014/396217
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:A validated health-related quality of life questionnaire in chronic obstructive pulmonary disease (COPD) with advantages of both generic- and disease-specific questionnaires is needed to capture patients' perspectives of severity and impact of the disease. The McGill COPD questionnaire was created to include...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2012/914138
更新日期:2012-11-01 00:00:00
abstract:Background:The FilmArray Respiratory Panel (FARP) (BioFire Diagnostics, Inc.) is a multiplex, polymerase chain reaction (PCR) technique that can detect 17 respiratory viruses and 3 bacterial targets in a single reaction. Immunocompromised hosts (ICH) with respiratory illnesses often undergo bronchoscopy with bronchoalv...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2018/2685723
更新日期:2018-04-05 00:00:00
abstract:BACKGROUND:Outdoor air pollution is a global problem with serious effects on human health, and children are considered to be highly susceptible to the effects of air pollution. OBJECTIVE:To conduct a comprehensive and updated systematic review of the literature reporting the effects of outdoor air pollution on the res...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:10.1155/2015/263427
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Although underused, written asthma action plans (AAPs) are associated with reduced numbers of emergency department (ED) visits and hospitalizations. OBJECTIVE:To describe the frequency of use and contents of any AAPs reported by patients presenting with exacerbations to three urban Canadian EDs. METHODS:Pr...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2014/498946
更新日期:2014-11-01 00:00:00
abstract::Common complications in PMV include changes in the airway clearance mechanism, pulmonary function, and respiratory muscle strength, as well as chest radiological changes such as atelectasis. Lung expansion therapy which includes IPPB and PEEP prevents and treats pulmonary atelectasis and improves lung compliance. Our ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/5624315
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Oropharyngeal (OP) symptoms are common in asthma patients using inhaled corticosteroids (ICSs) alone and in combination with a long-acting beta(2)-agonist (LABA). Patterns of medication use, level of asthma control and association with OP symptoms are not often reported in a nonstudy setting. OBJECTIVES:To ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,随机对照试验
doi:10.1155/2008/593723
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Noneosinophilic asthma has been regarded as a distinct phenotype characterized by a poor response to inhaled corticosteroids (ICS). OBJECTIVE:To determine whether noneosinophilic, steroid-naive asthmatic subjects show an improvement in asthma control, asthma symptoms and spirometry after four weeks of treat...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2011/108079
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Approximately 10% of patients hospitalized with community-acquired pneumonia (CAP) are bacteremic. Bacteremic Streptococcus pneumoniae pneumonia (BSPP) is the number one cause of mortality, representing up to 70% of all CAP deaths. In fact, all CAP guidelines have identified this issue as one of the most imp...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2004/461392
更新日期:2004-11-01 00:00:00
abstract::Clearance of inhaled technetium-99m diethylenetriaminepentaacetate (99mTc-DTPA) is a potential indicator of disease activity and progression in idiopathic pulmonary fibrosis (IPF). The objective of the present study was to evaluate the prognostic value of 99mTc-DTPA scans in IPF. A total of 22 patients (18 males), age...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2004/185705
更新日期:2004-10-01 00:00:00
abstract:Background:Tracheal stenosis is able to lead to airway obstruction. Objective:To evaluate the efficacy and safety profile of Montgomery T-tube implantation in patients with tracheal stenosis. Methods:Fifty-two patients with tracheal stenosis diagnosed between 2016 and 2019 were included in this retrospective cohort s...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2020/2379814
更新日期:2020-10-07 00:00:00
abstract:BACKGROUND:Monitoring noninvasive biomarkers of inflammation is an important adjunct in asthma therapy. OBJECTIVE:The goal of the present study was to identify airway and alveolar site(s) of inflammation using exhaled nitric oxide (NO) as a marker in asthmatic patients, and to evaluate the NO response to maintenance f...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2008/415391
更新日期:2008-05-01 00:00:00
abstract::Untreated patients with obstructive sleep apnea (OSA) are at increased risk for motor vehicle collisions; however, it is unclear how this should be translated into fitness-to-drive recommendations. Accordingly, the Canadian Thoracic Society (CTS) Sleep Disordered Breathing Clinical Assembly and the Canadian Sleep Soci...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2014/357327
更新日期:2014-03-01 00:00:00
abstract::A 25-year-old woman with narcolepsy and cataplexy was treated with well-recognized drugs for these conditions. Because she did not respond, a decision was made to treat her with sodium oxybate. ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:10.1155/2005/341295
更新日期:2005-05-01 00:00:00
abstract::In children with persistent asthma, inhaled glucocorticoids decrease symptoms and exacerbations, decrease the need for rescue bronchodilator medications, improve airway patency and reduce airway hyperresponsiveness. When administered in the lowest doses that prevent symptoms and eliminate the need for supplemental cou...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:10.1155/1999/957127
更新日期:1999-03-01 00:00:00
abstract::A 43-year-old man presented to hospital with pneumonia but only after discharge from hospital did he admit to deliberate prior inhalation of mercury. His pulmonary involvement appeared to resolve almost completely with antibiotics and supportive care. Nevertheless, persisting elevated urinary excretion of mercury requ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2006/898120
更新日期:2006-04-01 00:00:00
abstract::A case of intralobar pulmonary sequestration presenting with recurrent episodes of infection is reported. Pulmonary sequestration is a rare congenital malformation characterized by accessory lung tissue with no direct connection to the tracheobronchial tree and is supplied by an aberrant systemic artery. The aberrant ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2010/813106
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:The present study was designed to compare the performance of a new oxygen delivery device, the OxyArm (OA) (Southmedic Inc, Canada), with a standard nasal cannula (NC) (Salter-Style 1600, Salter Labs, USA) for both oxygen delivery and patient preference in patients on long-term oxygen therapy (LTOT). DESIGN...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,随机对照试验
doi:10.1155/2006/729878
更新日期:2006-11-01 00:00:00
abstract::A 30-year-old female presented shortly after cadaveric renal transplantation with respiratory distress typical of a bacterial infection. Following initial improvement, she developed progressive respiratory failure, initially felt to be secondary to cytomegalovirus infection. Two bronchoalveolar lavages were nondiagnos...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2000/248915
更新日期:2000-07-01 00:00:00
abstract::Physical activity is an important health behaviour in reducing morbidity and mortality in individuals with chronic obstructive pulmonary disease (COPD). Accurate measurement of the characteristics of physical activity is essential to understanding the impact of COPD on physical activity. In a previous article, we repo...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2019/2185207
更新日期:2019-09-17 00:00:00
abstract::Diffuse panbronchiolitis (DPB) is a rare, chronic bronchiolar disease in non-Asian populations and is therefore commonly overlooked in Western countries. It usually affects nonsmokers and manifests as persistent air flow obstruction, chronic cough and interstitial nodular opacities. Untreated, the prognosis is poor. I...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2003/786531
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Inhaled corticosteroids are effective in suppressing a chronic cough without asthma associated with sputum eosinophilia. OBJECTIVE:To investigate the inflammatory characteristics in the induced sputum of patients with a chronic cough without asthma or known cause and the effects of budesonide treatment on c...
journal_title:Canadian respiratory journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1155/1999/434901
更新日期:1999-07-01 00:00:00