Abstract:
PROBLEM:The function of hepatic allograft from non-heartbeating donors (NHBD) is significantly affected by warm ischemic injury before harvesting. MATERIALS AND METHODS:The effects of the endothelin (ET) antagonist TAK-044 and the platelet activating factor (PAF) antagonist E5880 on the function of grafts from NHBD were evaluated in a porcine orthotopic liver transplantation. The liver grafts were subjected to 90 min of warm ischemia and 4 hours cold preservation. Group 1 (n = 4; n is the number of donor/recipient pairs) was used as a control (untreated). In group 2 (n = 4), donors and recipients were treated with TAK-044 (3 mg/kg). In group 3 (n = 4), pigs were treated with E5880 (0.3 mg/kg). In group 4 (n = 4), pigs were treated with TAK-044 and E5880. RESULTS:The 7 day survival rate of the recipients in groups 1, 2, 3 and 4 was 0, 25, 25 and 100%, respectively (p<0.05, group 1 versus 4). The increases of the serum concentrations of aspartate transaminase, lactate dehydrogenase and arterial lactate 1-4 hours after transplantation were significantly inhibited in the treated groups. CONCLUSION:The blockade of ET and PAF has protective effects on the function of hepatic grafts from NHBD.
journal_name
Int Surgjournal_title
International surgeryauthors
Fukunaga K,Takada Y,Taniguchi H,Yuzawa K,Otsuka M,Todoroki T,Goto K,Fukao Ksubject
Has Abstractpub_date
1998-07-01 00:00:00pages
226-31issue
3eissn
0020-8868issn
2520-2456journal_volume
83pub_type
杂志文章abstract:BACKGROUND:Traumatic rupture of thoracic aorta caused by blunt trauma has been observed more frequently in recent years. The aim of this study was to evaluate the state of the art of diagnostic methods used to identify this injury and the surgical techniques used to repair it. METHODS:The study was performed in 29 pat...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::The aim of this study was to compare two preoperative staging procedures of non-small cell lung cancer (NSCLC): one using positron emission tomography (PET) and one using conventional imaging studies. Accuracy, effects on patient management, and costs were calculated. Four hundred thirteen consecutive patients with NS...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract::The influence of exogenous insulin on oxidation of U-14C-glucose was investigated by monitoring the production of 14CO2 in septic rats. Ten Wistar rats underwent ligation of the distal third of the caecum and the ligated caecum was punctured with a 21-G needle (septic rats: group S). A group of ten rats was not subjec...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract:OBJECTIVE:To compare the safety and effectiveness of laparosonic coagulating shears (LCS) and electrosurgery for use in laparoscopically assisted vaginal hysterectomy (LAVH). STUDY DESIGN:In this prospective study, patients undergoing LAVH performed by one of the authors from October 1997 to January 1998 were assigned...
journal_title:International surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-01-01 00:00:00
abstract::The records of 115 patients with stage D-2 prostate cancer treated with bilateral orchiectomy were reviewed to determine the effect of this procedure in previously untreated patients and in patients who had prior hormone therapy. Previously untreated patients survived 22.8 months while those who had prior hormone ther...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Carotid endarterectomy is a method of prophylaxis. A total of 367 carotid endarterectomies in 335 patients were performed during the period of 1989-1997: 222 (66.3%) were symptomatic and 113 (33.7%) asymptomatic patients. In all, 262 (78.2%) had unilateral, 41 (12.2%) contralateral occlusion and 32 (9.6%) bilateral ar...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1998-10-01 00:00:00
abstract::Primary carcinoma of the male urethra accounts for less than 1% of malignancies in men. Mucinous adenocarcinoma of the urethra is extremely rare, and its biologic behavior is poorly understood. We present herein a rare case of mucinous urethral adenocarcinoma in a male patient with longstanding ulcerative colitis and ...
journal_title:International surgery
pub_type: 杂志文章
doi:10.9738/INTSURG-D-13-00073.1
更新日期:2014-09-01 00:00:00
abstract::Regarding the complications of peptic ulcer, a perforation remains the most important fatal complication. The aim of our retrospective study was to determine relations between postoperative morbidity and comorbid disease or perioperative risk factors in perforated peptic ulcer. In total, 239 patients who underwent eme...
journal_title:International surgery
pub_type: 杂志文章
doi:10.9738/INTSURG-D-14-00187.1
更新日期:2015-05-01 00:00:00
abstract::Ocular chemical burns are frustrating disorders. The conjunctival surface provides a defense mechanism protecting against infection, desiccation, and injury, being centered in the epithelial lining of the ocular surface. A monocular case of severe acid chemical burn is presented. Postinjury-stratified epithelium in th...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Due to the rarity and large diversity of the primary retrorectal tumors (RTs), the diagnoses are often difficult and they can be misdiagnosed. We present our experience in light of scarce information available on the clinical manifestations of RTs. The retrospective study included 17 patients diagnosed as RTs between ...
journal_title:International surgery
pub_type: 杂志文章
doi:10.9738/INTSURG-D-15-00068.1
更新日期:2015-07-01 00:00:00
abstract::Fecoflowmetry (FFM) has been introduced to simulate natural anorectal evacuation. So far, few reports have described the effect of the herbal medicine Daikenchuto (DKT) on impaired anorectal motor function. The aim of this pilot study was to assess anorectal motor function by FFM in postoperatively impaired patients w...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:2010-10-01 00:00:00
abstract::The therapeutic value of extended lymph node dissection (D2) for gastric cancer remains controversial. Limited lymph node dissection, however, leaves cancer cells in the second tier of nodes (N2) in patients with N2 metastasis. This retrospective study was, therefore, undertaken to clarify which patients would be most...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract::NO is an important mediator in the generalized inflammatory response of the body during sepsis and septic shock. We investigated the possible effects of L-arginine and aminoguanidine on plasma NO levels and the interaction between NO levels and lung tissue damage and blood gases in sepsis. Fifty Wistar male rats were ...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::Two hundred and seven patients aged from 37 to 65 years with noninflammatory breast cancer treated by surgery without radiation were studied over a ten year period with a view to forecasting the prognosis on the basis of the immune status and treatment. The immunocompetence or immune status was studied in 121 patients...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::We analyzed data on the three-dimensional vascular anatomy of the right colon from the operative documents of 215 patients undergoing oncologic resection for right colon cancer. The right colic artery (RCA) was absent in 146 patients (67.9%), with the ileocolic artery (ICA) crossing the superior mesenteric vein (SMV) ...
journal_title:International surgery
pub_type: 杂志文章
doi:10.9738/cc20.1
更新日期:2011-10-01 00:00:00
abstract::Simultaneous pancreas and kidney transplantation (SPK) is considered an extremely effective and well-established therapeutic option for selected patients with end-stage renal disease (ESRD), secondary to type 1 diabetes. Vascular complications in pancreas transplantation are more common than in any other solid organ t...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:2008-07-01 00:00:00
abstract::Six hundred and two consecutive cases of gastric cancer and 204 of colorectal cancer in recent decades were investigated for recurrence. Recurrence occurred in 103 cases of gastric cancer and 31 cases of colorectal cancer. We classified three categories of recurrent patterns; A: local, B: peritoneal dissemination, and...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Ten cases of renal hypertension with uncommon causes were presented and unusual problems in their diagnosis and surgical management were discussed. These causes included segmental stenosis involving aberrant renal artery, renal artery stenosis in association with renal arteriovenous fistula, postoperative renal hypert...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1976-03-01 00:00:00
abstract::14 cases of silent perforation of the uterus by the Lippes loop are presented. Loop perforations are usually asymptomatic and can be treated conservatively. If complications occur, they require surgical intervention with posterior colpotomy being the procedure of choice if the loop is in the pelvic cavity. Laparoto...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1973-05-01 00:00:00
abstract::Free microvascular grafts have many advantages over conventional bone grafts. Above all they do not undergo creeping substitution and live on their own vessels, thus being able to heal quickly and fight infection. Research in rabbits has been done with radiographic, scintigraphic and light and fluorescence histologic ...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Proximal gastrectomy (PG) has been introduced for patients who are preoperatively diagnosed with early gastric cancer located in the upper third of the stomach. In the present study, we compared the prognosis of patients who underwent PG with that of patients who underwent total gastrectomy (TG). Between 1997 and 2006...
journal_title:International surgery
pub_type: 杂志文章
doi:10.9738/CC150.1
更新日期:2012-07-01 00:00:00
abstract::Pancreaticoduodenectomy is considered the standard operation for periampullary tumors. Despite major advances in pancreatic surgery, pancreatic fistula is still an important cause of morbidity and mortality after pancreaticoduodenectomy. Meticulous surgical technique and proper reconstruction of the pancreas are essen...
journal_title:International surgery
pub_type: 杂志文章
doi:10.9738/INTSURG-D-14-00095.1
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:The prognostic value of intra-operative peritoneal lavage cytology and chemotherapy was evaluated retrospectively. METHOD:Lavage cytology was performed in 257 patients. Prognosis was investigated in 85 of pT3 and pT4 patients with radical gastrectomy. Intra-operative chemotherapy was selected according to t...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
abstract::99mTc-MIBI-guided detection of abnormal parathyroid glands in primary hyperparathyroidism (1-HPT) has become a popular and effective technique, but its efficacy for detecting the ectopic glands of secondary hyperparathyroidism (2-HPT) is still controversial. Of the 2-HPT cases from 2000 to 2004, 14 ectopic parathyroid...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:2009-04-01 00:00:00
abstract::The authors describe the present surgical procedure for duodenal ulcer; this consists of vagotomy in association with resection of the antral mucosa, and sliding the fundus mucosa to cover the naked surface. The gastroduodenal junction is sewn as an enlarged Weimberg pyloroplasty. A series of 20 patients were operated...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Incidence of cholelithiasis in the teaching hospital population of India has been reported. The study suggests that North Indians are more prone to cholelithiasis than South Indians. Apparently this variation is related to dietary and geographical factors. ...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1977-03-01 00:00:00
abstract::Expanded polytetrafluoroethylene (Gore Tex) grafts were used for the replacement of the superior or inferior vena cava in dogs. When examined 2 weeks to 18 months after the replacement, the overall patency rate was 82%. If neither deformation nor narrowing of the graft on examination by cavagram had occurred within 14...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1981-07-01 00:00:00
abstract::Totally implantable access ports (TIAPs) are generally used in oncology. Few studies have addressed complications associated with the insertion site. A total of 233 consecutive oncology patients were enrolled to receive TIAP inserts via internal jugular vein (IJV) or subclavian vein (SV). Data on clinicopathologic par...
journal_title:International surgery
pub_type: 杂志文章
doi:10.9738/INTSURG-D-13-00185.1
更新日期:2014-03-01 00:00:00
abstract::Immediate breast reconstruction with the transverse rectus abdominis musculocutaneous (TRAM) flap after skin-sparing mastectomy is becoming an increasingly performed procedure in patients with ductal carcinoma in situ, early invasive breast cancer, and prophylactic mastectomy. Through a periareolar approach, it is pos...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:2001-10-01 00:00:00
abstract::Results obtained with temporary ileal cecostomy in 23 patients are reported. Particular attention is given to the incidence of anastomotic leakage, morbidity, mortality, hospitalization and nursing. The results achieved were successful and, although the series presented is small, the authors suggest that this techniqu...
journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1982-10-01 00:00:00