PCV chemotherapy for recurrent oligodendrogliomas and oligoastrocytomas.

Abstract:

OBJECTIVE:The role of chemotherapy in the treatment of low-grade oligodendrogliomas and oligoastrocytomas is still unclear. A Phase II study was conducted to determine the benefits and toxicity of the procarbazine, lomustine, and vincristine (PCV) regimen in patients with low-grade oligodendrogliomas and oligoastrocytomas recurrent after surgery alone or surgery with radiotherapy. METHODS:Patients with both enhancing and nonenhancing tumors were treated with up to six cycles of standard PCV, and response was evaluated by conventional criteria based on computed tomography or magnetic resonance imaging. RESULTS:Sixteen of 26 patients (62%) responded to PCV: 3 (12%) experienced complete response, 13 (50%) experienced partial response, 8 (31%) had stable disease, and 2 (8%) had progressive disease. All symptomatic patients who responded and three with stable disease improved in seizure frequency, lateralizing signs, and symptoms of intracranial hypertension. The response rate for patients with enhancing lesions revealed by computed tomography or magnetic resonance imaging (74%) was significantly higher than that of patients with nonenhancing lesions (29%) (P < 0.05). Both oligodendrogliomas and oligoastrocytomas responded to PCV, with complete responses occurring in association with pure tumors only. The median time to tumor progression of all 26 patients was 24 months and was significantly longer for those with oligodendrogliomas compared with those with oligoastrocytomas (32 versus 12 mo) (P < 0.001). Chemotherapy was well tolerated, with mild hematological toxicity and rare skin rashes being the most frequent sequelae. CONCLUSION:These results suggest that chemotherapy with PCV is effective in the treatment of recurrent low-grade oligodendrogliomas and oligoastrocytomas.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Soffietti R,Rudà R,Bradac GB,Schiffer D

doi

10.1097/00006123-199811000-00035

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

1066-73

issue

5

eissn

0148-396X

issn

1524-4040

journal_volume

43

pub_type

临床试验,杂志文章
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    authors: Naidech AM,Bendok BR,Bernstein RA,Alberts MJ,Batjer HH,Watts CM,Bleck TP

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  • Adjacent fracture-dislocations of the lumbosacral spine: case report.

    abstract:OBJECTIVE AND IMPORTANCE:Traumatic fracture-dislocations of the lumbosacral junction are rare, with all previously reported cases involving fracture-dislocations at a single level. No cases of multiple fracture-dislocations of contiguous spinal segments in the lumbosacral spine have been reported. A case of traumatic a...

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    doi:10.1097/00006123-199905000-00117

    authors: Kaplan SS,Wright NM,Yundt KD,Lauryssen C

    更新日期:1999-05-01 00:00:00

  • The use of intraoperative electrophysiology for the placement of spinal cord stimulator paddle leads under general anesthesia.

    abstract:BACKGROUND:Placement of spinal cord stimulating paddle leads has traditionally been performed under local anesthesia with intravenous sedation to allow intraoperative confirmation of appropriate placement. It may be difficult to maintain appropriate sedation in certain patients because of medical comorbidities. Further...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/NEU.0b013e318232ff29

    authors: Mammis A,Mogilner AY

    更新日期:2012-06-01 00:00:00

  • Dural reconstruction with fascia, titanium mesh, and bone screws: technical note.

    abstract:OBJECTIVE:After the resection of cranial base tumors, there may not be enough free dural margin left for reconstruction after involved bone and dura have been removed. In such a situation, dural reconstruction becomes a problem. We propose a new technique of dural closure in such cases. METHODS:A fascial graft is prep...

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    doi:10.1097/00006123-200109000-00043

    authors: Sekhar LN,Sarma S,Morita A

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  • Rapid saccular aneurysm induction by elastase application in vitro.

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    authors: Miskolczi L,Guterman LR,Flaherty JD,Szikora I,Hopkins LN

    更新日期:1997-07-01 00:00:00

  • Usefulness of the orbitofrontomalar approach associated with bone reconstruction for frontotemporosphenoid meningiomas.

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    authors: Pellerin P,Lesoin F,Dhellemmes P,Donazzan M,Jomin M

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  • Clinical evaluation and follow-up outcome of diffusion tensor imaging-based functional neuronavigation: a prospective, controlled study in patients with gliomas involving pyramidal tracts.

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    更新日期:2007-11-01 00:00:00

  • Magnetic resonance imaging in cases of spinal dural arteriovenous malformation.

    abstract::Two patients with spinal dural arteriovenous malformations associated with intramedullary changes confirmed by the T2-weighted magnetic resonance imaging (MRI) scans are reported. The characteristics of the MRI findings for these 2 patients were as follows. 1) In the T2-weighted spin-echo image, intramedullary changes...

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  • The Energy Index Does Not Affect Local Control of Brain Metastases Treated by Gamma Knife Stereotactic Radiosurgery.

    abstract:BACKGROUND:The energy index (EI) is a measure of dose homogeneity within a target volume calculated by the integral dose divided by the product of prescription dose and tumor volume. OBJECTIVE:To assess whether a higher EI is associated with greater local control for brain metastases (BMs) treated by Gamma Knife radio...

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    doi:10.1227/NEU.0000000000000750

    authors: Jani A,Rozenblat T,Yaeh AM,Nanda T,Saad S,Qureshi YH,Feng W,Sisti MB,Bruce JN,McKhann GM 2nd,Lesser J,Lassman AB,Isaacson SR,Wang TJ

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  • Perioperative fever and outcome in surgical patients with aneurysmal subarachnoid hemorrhage.

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    pub_type: 杂志文章,多中心研究,随机对照试验

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    authors: Lüdemann W,Stan AC,Tatagiba M,Samii M

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  • Benign hemangioendothelioma involving the central nervous system: "strawberry nevus" of the neuraxis.

    abstract::Benign hemangioendothelioma is rarely included in discussions of vascular neoplasms involving the central nervous system, whereas it is a well-defined entity outside the neuraxis. We present four cases of benign hemangioendothelioma, including an infantile hemangioendothelioma with venous drainage into the transverse ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

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    authors: Pearl GS,Takei Y,Tindall GT,O'Brien MS,Payne NS,Hoffman JC

    更新日期:1980-09-01 00:00:00

  • The impact of the body mass index on outcome after subarachnoid hemorrhage: is there an obesity paradox in SAH? A retrospective analysis.

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    journal_title:Neurosurgery

    pub_type: 杂志文章

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    authors: Platz J,Güresir E,Schuss P,Konczalla J,Seifert V,Vatter H

    更新日期:2013-08-01 00:00:00

  • Extracranial posterior inferior cerebellar artery aneurysm causing isolated intraventricular hemorrhage: a case report.

    abstract::The authors report the unusual case of an aneurysm arising on an extracranial loop of the left posterior inferior cerebellar artery (PICA). The computed tomographic scan showed an isolated hemorrhage in the lateral ventricles, and the lesion was recognized 1.5 cm below the foramen magnum at the level of the atlas. The...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198812000-00020

    authors: Ruelle A,Cavazzani P,Andrioli G

    更新日期:1988-12-01 00:00:00

  • Percutaneous endoscopic lumbar foraminotomy: an advanced surgical technique and clinical outcomes.

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    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000000361

    authors: Ahn Y,Oh HK,Kim H,Lee SH,Lee HN

    更新日期:2014-08-01 00:00:00

  • Stereotactic aspiration and antibiotic treatment combined with hyperbaric oxygen therapy in the management of bacterial brain abscesses.

    abstract:OBJECTIVE:Despite advances in surgical techniques in the management of the brain abscess, long-term antibiotics are as crucial to cure as the initial surgical procedure itself. This study was designed to evaluate the effect of adjuvant hyperbaric oxygen (HBO) therapy on the duration of antibiotic treatment. METHODS:Be...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000316257.21478.5b

    authors: Kutlay M,Colak A,Yildiz S,Demircan N,Akin ON

    更新日期:2008-02-01 00:00:00

  • Aneurysmal Subarachnoid Hemorrhage: Trends, Outcomes, and Predictions From a 15-Year Perspective of a Single Neurocritical Care Unit.

    abstract:BACKGROUND:Aneurysmal subarachnoid hemorrhage (aSAH) is associated with disproportionally high mortality and long-term neurological sequelae. Management of patients with aSAH has changed markedly over the years, leading to improvements in outcome. OBJECTIVE:To describe trends in aSAH care and outcome in a high-volume ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyaa465

    authors: Samuels OB,Sadan O,Feng C,Martin K,Medani K,Mei Y,Barrow DL

    更新日期:2020-12-11 00:00:00

  • Posterior interhemispheric approach: surgical technique, application to vascular lesions, and benefits of gravity retraction.

    abstract:OBJECTIVE:To review an experience with the posterior interhemispheric approach applied to vascular lesions in the posterior midline, to examine the effects of patient position and gravity retraction of the occipital lobe, and to identify circumstances requiring increased exposure by sectioning the falx and tentorium. ...

    journal_title:Neurosurgery

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    doi:10.1227/01.NEU.0000219880.66309.85

    authors: Chi JH,Lawton MT

    更新日期:2006-07-01 00:00:00

  • Anterior choroidal artery syndrome after surgery for internal carotid artery aneurysms.

    abstract::We report five patients with anterior choroidal artery syndrome after surgery for internal carotid artery aneurysms. All patients suffered hemiparesis, and hemisensory loss and homonymous hemianopsia were identified in 2 patients. The characteristic triad of the syndrome was recognized in only 1 patient. Dominant and ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199207000-00021

    authors: Suzuki H,Fujita K,Ehara K,Tamaki N

    更新日期:1992-07-01 00:00:00

  • What is the Surgical Benefit of Utilizing 5-Aminolevulinic Acid for Fluorescence-Guided Surgery of Malignant Gliomas?

    abstract::The current neurosurgical goal for patients with malignant gliomas is maximal safe resection of the contrast-enhancing tumor. However, a complete resection of the contrast-enhancing tumor is achieved only in a minority of patients. One reason for this limitation is the difficulty in distinguishing viable tumor from no...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/NEU.0000000000000929

    authors: Hadjipanayis CG,Widhalm G,Stummer W

    更新日期:2015-11-01 00:00:00

  • Primary osteogenic sarcoma of the skull: case report.

    abstract::A case of primary osteogenic sarcoma of the skull with metastases to the lungs, left diaphragm, 2nd lumbar and 1st sacral vertebral bodies, and both femoral heads was presented. A young man with a lump over his right parieto-occipital region since the age of 14 had noticed rapid growth of the mass after having experie...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

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    更新日期:1981-09-01 00:00:00

  • A New Protocol for Anticoagulation With Tirofiban During Flow Diversion.

    abstract:BACKGROUND:Flow diversion is increasingly used to treat intracranial aneurysms. In previous reports, patients were pretreated with aspirin and clopidogrel before the intervention for the prevention of thromboembolic complications. OBJECTIVE:To assess the safety and efficacy of a new protocol for anticoagulation using ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000001071

    authors: Chalouhi N,Jabbour P,Daou B,Starke RM,Shields B,Hasan DM

    更新日期:2016-05-01 00:00:00

  • The morning visit by Oliver Wendell Holmes, Sr., M.D.

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    pub_type: 传,历史文章,杂志文章

    doi:10.1227/01.NEU.0000351280.04013.65

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    更新日期:2009-10-01 00:00:00

  • Neurocutaneous melanosis presenting as an intradural mass of the cervical canal: magnetic resonance features and the presence of melanin as a clue to diagnosis: case report.

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    pub_type: 杂志文章

    doi:10.1227/00006123-199410000-00023

    authors: Poe LB,Roitberg D,Galyon DD

    更新日期:1994-10-01 00:00:00

  • Is Admission Lipoprotein-Associated Phospholipase A2 a Novel Predictor of Vasospasm and Outcome in Patients With Aneurysmal Subarachnoid Hemorrhage?

    abstract:BACKGROUND:The relationships between lipoprotein-associated phospholipase A2 (Lp-PLA2) level, vasospasm, and clinical outcome of patients with aneurysmal subarachnoid hemorrhage (aSAH) are still unclear. OBJECTIVE:To identify the associations between admission Lp-PLA2 and vasospasm following subarachnoid hemorrhage an...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyz041

    authors: Ding CY,Cai HP,Ge HL,Yu LH,Lin YX,Kang DZ

    更新日期:2020-01-01 00:00:00

  • Transcranial stab wounds: a report of three cases and suggestions for management.

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    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198811000-00022

    authors: Herring CJ,Lumsden AB,Tindall SC

    更新日期:1988-11-01 00:00:00

  • Catastrophic subarachnoid hemorrhage resulting from ruptured vertebrobasilar dolichoectasia: case report.

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    pub_type: 杂志文章

    doi:10.1097/00006123-199802000-00108

    authors: Rabb CH,Barnwell SL

    更新日期:1998-02-01 00:00:00

  • The Nationwide Burden of Neurological Conditions Requiring Emergency Neurosurgery.

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    pub_type: 杂志文章

    doi:10.1093/neuros/nyx055

    authors: De la Garza Ramos R,Goodwin CR,Nakhla J,Nasser R,Yassari R,Flamm ES,Bydon A,Colby G,Sciubba DM

    更新日期:2017-09-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1227/00006123-198809000-00021

    authors: Matsushima T,Inoue T,Takeshita I,Fukui M,Iwaki T,Kitamoto T

    更新日期:1988-09-01 00:00:00

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    abstract::Two nitrosourea compounds--1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)--have been used in the treatment of primary and metastatic brain tumors after operation and/or radiotherapy. Hematological and nonhematological toxicity were recorded in 272 patients treated b...

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    pub_type: 杂志文章

    doi:10.1227/00006123-198209000-00012

    authors: Robustelli della Cuna G,Paoletti P,Bernardo G,Knerich R,Butti G,Cuzzoni Q

    更新日期:1982-09-01 00:00:00