Abstract:
:According to modern views of the cerebellum in motor control, each cerebellar functional unit, or microzone, learns how to execute predictive and coordinative control, based on long-term depression of the granule cell-Purkinje cell synapses. In the present paper, in light of recent experimental and theoretical studies on synaptic elimination and cerebellar motor learning, a model of the formation of cerebellar microzones by climbing fiber synaptic elimination is proposed. It is shown that competition for an activity-dependent supply of neurotrophic factor can reproduce the spatio-temporal characteristics of climbing fiber synaptic elimination. It is further shown that when this elimination is accurate, motor coordination can be acquired in an arm reaching task. In view of the results of the present study, several predictions are proposed.
journal_name
Biol Cybernjournal_title
Biological cyberneticsauthors
Schweighofer Ndoi
10.1007/s004220050462subject
Has Abstractpub_date
1998-08-01 00:00:00pages
97-107issue
2eissn
0340-1200issn
1432-0770journal_volume
79pub_type
杂志文章abstract::The response of a healthy lateral eye of Limulus to constant, uniform and sufficiently intense light stimulation, consists of a sustained oscillatory discharge, all ommatidia firing synchronously in bursts, at intervals of about 0.2s (Barlow and Fraioli, 1978). This response has been analysed by a computer simulation,...
journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00336944
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journal_title:Biological cybernetics
pub_type: 杂志文章
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journal_title:Biological cybernetics
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journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s004220050515
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journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00336972
更新日期:1982-01-01 00:00:00
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journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00204400
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journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-009-0309-6
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pub_type: 杂志文章
doi:10.1007/BF00203232
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journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s004220050521
更新日期:1999-04-01 00:00:00
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journal_title:Biological cybernetics
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pub_type: 历史文章,杂志文章
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pub_type: 杂志文章
doi:10.1007/s00422-009-0338-1
更新日期:2009-10-01 00:00:00
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journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-005-0581-z
更新日期:2005-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00422-009-0310-0
更新日期:2009-05-01 00:00:00
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journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00340323
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journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00204057
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journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00202613
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journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/BF00363955
更新日期:1988-01-01 00:00:00
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journal_title:Biological cybernetics
pub_type: 杂志文章
doi:10.1007/s00422-009-0325-6
更新日期:2009-08-01 00:00:00
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journal_title:Biological cybernetics
pub_type: 杂志文章
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journal_title:Biological cybernetics
pub_type: 杂志文章
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journal_title:Biological cybernetics
pub_type: 杂志文章
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journal_title:Biological cybernetics
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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