A model of activity-dependent formation of cerebellar microzones.

Abstract:

:According to modern views of the cerebellum in motor control, each cerebellar functional unit, or microzone, learns how to execute predictive and coordinative control, based on long-term depression of the granule cell-Purkinje cell synapses. In the present paper, in light of recent experimental and theoretical studies on synaptic elimination and cerebellar motor learning, a model of the formation of cerebellar microzones by climbing fiber synaptic elimination is proposed. It is shown that competition for an activity-dependent supply of neurotrophic factor can reproduce the spatio-temporal characteristics of climbing fiber synaptic elimination. It is further shown that when this elimination is accurate, motor coordination can be acquired in an arm reaching task. In view of the results of the present study, several predictions are proposed.

journal_name

Biol Cybern

journal_title

Biological cybernetics

authors

Schweighofer N

doi

10.1007/s004220050462

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

97-107

issue

2

eissn

0340-1200

issn

1432-0770

journal_volume

79

pub_type

杂志文章
  • Relevance of the single ommatidium performance in determining the oscillatory response of the Limulus retina.

    abstract::The response of a healthy lateral eye of Limulus to constant, uniform and sufficiently intense light stimulation, consists of a sustained oscillatory discharge, all ommatidia firing synchronously in bursts, at intervals of about 0.2s (Barlow and Fraioli, 1978). This response has been analysed by a computer simulation,...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/BF00336944

    authors: Barbi M,Ferdeghini EM

    更新日期:1980-01-01 00:00:00

  • Pattern separability in a random neural net with inhibitory connections.

    abstract::Some interesting properties on pattern separation have been shown through researches by neural models of cerebellar cortex. It seems to us that those results are a part of the properties of pattern separation. A two layer random nerve net with inhibitory connections is given as a model of the cerebellar cortex. The mo...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/BF00336858

    authors: Torioka T

    更新日期:1979-09-01 00:00:00

  • Contrast Discrimination by the human visual system.

    abstract::In vision of everyday scenes, features requiring detection are frequently observed in the presence of suprathreshold background structures. Detection of such features is a contrast discrimination task and is often necessary for the subsequent process of recognition. In order to provide a description of this task, cont...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/BF00326678

    authors: Burton GJ

    更新日期:1981-01-01 00:00:00

  • An architectural hypothesis for direction selectivity in the visual cortex: the role of spatially asymmetric intracortical inhibition.

    abstract::Within a linear field approach, an architectural model for simple cell direction selectivity in the visual cortex is proposed. The origin of direction selectivity is related to recurrent intracortical interactions with a spatially asymmetric character along the axis of stimulus motion. No explicit asymmetric temporal ...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s004220050515

    authors: Sabatini SP,Solari F

    更新日期:1999-03-01 00:00:00

  • A model for the economical encoding of the visual image in cerebral cortex.

    abstract::We propose a model for the first stage of the cortical transformation of the visual image based on the principle that the cortex encodes the information with the minimum number of channels mathematically needed. We restrict our model to be consistent with the data on size adaptations, the known relationships of acuity...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/BF00336972

    authors: Sakitt B,Barlow HB

    更新日期:1982-01-01 00:00:00

  • The emergence of long-lasting transients of activity in simple neural networks.

    abstract::The question was investigated whether long-lasting transients of activity, observed to occur in the intact cerebral cortex (EEG slow (delta) waves and 'K' complexes) as well as in isolated tissues cultured in vitro, can also emerge in a model network of excitatory and inhibitory cells. We show that such transients can...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/BF00204400

    authors: van Ooyen A,van Pelt J,Corner MA,da Silva FH

    更新日期:1992-01-01 00:00:00

  • Computational modeling of synchronization process of the circadian timing system of mammals.

    abstract::This paper presents a model for the circadian temporization system of mammals which associates the synchronization dynamics of coupling oscillators to a set of equations able to reproduce the synaptic characteristics of somatodendritic membrane of neurons. The circadian timing system is organized in a way to receive i...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s00422-009-0309-6

    authors: Cardoso FR,de Oliveira Cruz FA,Silva D,Cortez CM

    更新日期:2009-05-01 00:00:00

  • Binding by temporal structure in multiple feature domains of an oscillatory neuronal network.

    abstract::An important step in visual processing is the segregation of objects in a visual scene from one another and from the embedding background. According to current theories of visual neuroscience, the different features of a particular object are represented by cells which are spatially distributed across multiple visual ...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/BF00203232

    authors: Schillen TB,König P

    更新日期:1994-01-01 00:00:00

  • The dynamics of goal-directed rhythmical aiming.

    abstract::Based on the kinematics of goal-directed aiming movements in a reciprocal Fitts' task, a minimal limit cycle model is proposed that is capable of producing the behavior observed at levels of task difficulty ranging from 3 to 7. From graphical and statistical analyses of the phase planes, Hooke's planes and velocity pr...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s004220050521

    authors: Mottet D,Bootsma RJ

    更新日期:1999-04-01 00:00:00

  • A control model of human tongue movements in speech.

    abstract::Tongue movements during speech production have been investigated by means of a simple yet realistic biomechanical model, based on a finite elements modeling of soft tissues, in the framework of the equilibrium point hypothesis (lambda-model) of motor control. In particular, the model has been applied to the estimation...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s004220050362

    authors: Sanguineti V,Laboissière R,Payan Y

    更新日期:1997-07-01 00:00:00

  • Neuroscience from a mathematical perspective: key concepts, scales and scaling hypothesis, universality.

    abstract::This article analyzes the question of whether neuroscience allows for mathematical descriptions and whether an interaction between experimental and theoretical neuroscience can be expected to benefit both of them. It is argued that a mathematization of natural phenomena never happens by itself. First, appropriate key ...

    journal_title:Biological cybernetics

    pub_type: 历史文章,杂志文章

    doi:10.1007/s00422-014-0609-3

    authors: van Hemmen JL

    更新日期:2014-10-01 00:00:00

  • Modelling place memory in crickets.

    abstract::Insects can remember and return to a place of interest using the surrounding visual cues. In previous experiments, we showed that crickets could home to an invisible cool spot in a hot environment. They did so most effectively with a natural scene surround, though they were also able to home with distinct landmarks or...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s00422-009-0338-1

    authors: Mangan M,Webb B

    更新日期:2009-10-01 00:00:00

  • Instability helps virtual flies to mate.

    abstract::In this paper we perform a bifurcation analysis for a discrete time dynamical system, describing the behavior of a virtual fly, developed by Böddeker and Egelhaaf (2003). Like real blowflies, the virtual counterparts exhibit a dichotomous behavior: they catch small targets but follow big objects at a constant distance...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s00422-005-0581-z

    authors: Hüls T

    更新日期:2005-09-01 00:00:00

  • Reduced order multiport parallel and multidirectional neural associative memories.

    abstract::This paper proposes multiport parallel and multidirectional intraconnected associative memories of outer product type with reduced interconnections. Some new reduced order memory architectures such as k-directional and k-port parallel memories are suggested. These architectures are, also, very suitable for implementat...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s00422-009-0310-0

    authors: Bhatti AA

    更新日期:2009-05-01 00:00:00

  • A posteriori time-varying filtering of averaged evoked potentials. II. Mathematical and computational aspects.

    abstract::The problem of estimating an unknown transient signal, given an ensemble of waveforms, in which this signal appears as a nonrandom component in the presence of additive noise is considered. This problem is solved by generalizing the method of "a posteriori 'Wiener' filtering". In the new method, the ensemble average i...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/BF00340323

    authors: de Weerd JP,Kap JI

    更新日期:1981-01-01 00:00:00

  • Discharge patterns of tonically firing human motoneurones.

    abstract::We have attempted to reconcile the different patterns of distribution of interspike intervals that are found in motoneurones made to discharge by intracellular injection of constant current in reduced animal preparations and by voluntary control in human subjects. We recorded long spike trains from single motor units ...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/BF00204057

    authors: Poliakov AV,Miles TS,Nordstrom MA

    更新日期:1995-07-01 00:00:00

  • Multifrequency behavioral patterns and the phase attractive circle map.

    abstract::With relative phase as a collective variable or order parameter, phase attractive dynamics can capture the temporally coherent behavior of a large number of different experimental systems. We present results from multifrequency coordination experiments in humans showing: a) that phase attraction persists especially fo...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/BF00202613

    authors: deGuzman GC,Kelso JA

    更新日期:1991-01-01 00:00:00

  • Physiology based simulation model of triangle shape recognition.

    abstract::The present paper considers the relation between the shape of a triangle and probability of its recognition. An effect of triangle size on perception of its shape is examined in the first experiment. In the second the loci of eye fixations during triangle recognition task are recorded and analysed. A simulation model ...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/BF00363955

    authors: Pizlo Z

    更新日期:1988-01-01 00:00:00

  • Predictive feedback in human simulated pendulum balancing.

    abstract::In studies of human balance, it is common to fit stimulus-response data by tuning the time-delay and gain parameters of a simple delayed feedback model. Many interpret this fitted model, a simple delayed feedback model, as evidence that predictive processes are not required to explain existing data on standing balance...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s00422-009-0325-6

    authors: Gawthrop P,Loram I,Lakie M

    更新日期:2009-08-01 00:00:00

  • The frequency of seeing square wave density modulations in random dot patterns.

    abstract::A theoretical and experimental study on the detection of a square wave pattern of random dots is presented. Our theory applies to two-alternative forced choice experiments as well as to "seen"-"not seen" discrimination experiments. In our experiments we used the forced choice method. The theory provides a good descrip...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/BF00318084

    authors: Lelkens AM,Oppeneer PM

    更新日期:1983-01-01 00:00:00

  • Distribution of axon diameters in cortical white matter: an electron-microscopic study on three human brains and a macaque.

    abstract::The aim of this study was to obtain information on the axonal diameters of cortico-cortical fibres in the human brain, connecting distant regions of the same hemisphere via the white matter. Samples for electron microscopy were taken from the region of the superior longitudinal fascicle and from the transitional white...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s00422-014-0626-2

    authors: Liewald D,Miller R,Logothetis N,Wagner HJ,Schüz A

    更新日期:2014-10-01 00:00:00

  • An interspike interval method for computing phase locking from neural firing.

    abstract::Inner hair cells (IHCs) transform the mechanical movements of the basilar membrane into electrical impulses. The impulse coding of the IHCs is the main information carrier in the auditory process and is the basis for improvements of cochlea implants as well as for low rate, high-quality speech processing and compressi...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s004220050582

    authors: Meyer-Bäse U,Meyer-Bäse A,Scheich H

    更新日期:2000-04-01 00:00:00

  • Investigation of transmitter-receptor interactions by analyzing postsynaptic membrane noise using stochastic kinetics.

    abstract::The stoichiometric and kinetic details of transmitter-receptor interaction (the number of conformations and the rate constants of conformation changes( in synaptic transmission have been investigated analyzing postsynaptic membrane noises by the aid of the fluctuation-dissipation theorem of stochastic chemical kinetic...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/BF00337450

    authors: Erdi P,Ropolyi L

    更新日期:1979-02-02 00:00:00

  • The Gamma renewal process as an output of the diffusion leaky integrate-and-fire neuronal model.

    abstract::Statistical properties of spike trains as well as other neurophysiological data suggest a number of mathematical models of neurons. These models range from entirely descriptive ones to those deduced from the properties of the real neurons. One of them, the diffusion leaky integrate-and-fire neuronal model, which is ba...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s00422-016-0690-x

    authors: Lansky P,Sacerdote L,Zucca C

    更新日期:2016-06-01 00:00:00

  • Dynamical synaptic plasticity: a model and connection to some experiments.

    abstract::Using a modified version of a phenomenological model for the dynamics of synaptic plasticity, we examine some recent experiments of Wu et al. [(2001) J Physiol 533:745-755]. We show that the model is quantitatively consistent with their experimental protocols producing long-term potentiation (LTP) and long-term depres...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s00422-002-0376-4

    authors: Whitehead A,Rabinovich MI,Huerta R,Zhigulin VP,Abarbanel HD

    更新日期:2003-03-01 00:00:00

  • Comparison of congruence judgment and auditory localization tasks for assessing the spatial limits of visual capture.

    abstract::Vision typically has better spatial accuracy and precision than audition and as a result often captures auditory spatial perception when visual and auditory cues are presented together. One determinant of visual capture is the amount of spatial disparity between auditory and visual cues: when disparity is small, visua...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s00422-016-0706-6

    authors: Bosen AK,Fleming JT,Brown SE,Allen PD,O'Neill WE,Paige GD

    更新日期:2016-12-01 00:00:00

  • A dynamical model for reflex activated head movements in the horizontal plane.

    abstract::We present a controls systems model of horizontal-plane head movements during perturbations of the trunk, which for the first time interfaces a model of the human head with neural feedback controllers representing the vestibulocollic (VCR) and the cervicocollic (CCR) reflexes. This model is homeomorphic such that mode...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s004220050297

    authors: Peng GC,Hain TC,Peterson BW

    更新日期:1996-10-01 00:00:00

  • Dynamic updating of distributed neural representations using forward models.

    abstract::In this paper, we present a continuous attractor network model that we hypothesize will give some suggestion of the mechanisms underlying several neural processes such as velocity tuning to visual stimulus, sensory discrimination, sensorimotor transformations, motor control, motor imagery, and imitation. All of these ...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s00422-006-0131-3

    authors: Sauser EL,Billard AG

    更新日期:2006-12-01 00:00:00

  • Three-dimensional kinematic analysis of influence of hand orientation and joint limits on the control of arm postures and movements.

    abstract::The problems related to kinematic redundancy in both task and joint space were investigated for arm prehension movements in this paper. After a detailed analysis of kinematic redundancy of the arm, it is shown that the redundancy problem is ill posed only for the control of hand orientation. An experiment was then des...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s004220050538

    authors: Wang X

    更新日期:1999-06-01 00:00:00

  • Torque-stiffness-controlled dynamic walking with central pattern generators.

    abstract::Walking behavior is modulated by controlling joint torques in most existing passivity-based bipeds. Controlled Passive Walking with adaptable stiffness exhibits controllable natural motions and energy efficient gaits. In this paper, we propose torque-stiffness-controlled dynamic bipedal walking, which extends the conc...

    journal_title:Biological cybernetics

    pub_type: 杂志文章

    doi:10.1007/s00422-014-0625-3

    authors: Huang Y,Vanderborght B,Van Ham R,Wang Q

    更新日期:2014-12-01 00:00:00