Abstract:
:STRESS ULCERS OCCUR frequently in intensive care unit patients who have intracranial disease. After major physiological stress, endoscopic evidence of mucosal lesions of the gastrointestinal tract appears within 24 hours of injury; 17% of these erosions progress to clinically significant bleeding. Gastrointestinal hemorrhage has been associated with mortality rates of up to 50%. The pathogenesis of stress ulcers may not be completely understood, but gastric acid and pepsin appear to play significant roles. Antacids, H2 antagonists, and sucralfate are effective prophylactic agents in the medical/surgical intensive care unit. Appropriate therapy for neurosurgical patients remains unclear, however. This review summarizes the current literature regarding the pathogenesis and therapy of stress ulcers in neurosurgical patients.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Lu WY,Rhoney DH,Boling WB,Johnson JD,Smith TCdoi
10.1097/00006123-199708000-00017subject
Has Abstractpub_date
1997-08-01 00:00:00pages
416-25; discussion 425-6issue
2eissn
0148-396Xissn
1524-4040journal_volume
41pub_type
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