Decreased CD5+ B cells during the acute phase of Kawasaki disease.

Abstract:

:We investigated the changes of CD5+ B cells in the peripheral blood of 20 Kawasaki disease (KD) patients. The percentage of CD5+ B cells in the total lymphocytes and in the total B cells significantly decreased during the acute phase of KD(p < 0.01), compared to that in the age-matched normal control subjects. After intravenous immunoglobulin(IVIG) treatment, the percentage of CD5+ B cells increased, but was still lower than that in the normal controls(p < 0.01). During the convalescent phase of the disease, the percentage of CD5+ B cells was restored to the normal levels. The levels of CD5+ B cell percentage in the total B cells of the patients with acute febrile disease showed similar levels to age-matched normal controls. The decreased CD5+ B cells in the patients with KD provides an additional abnormal immunological finding during the acute phase of the disease.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Kim HS,Noh GW,Kim DS,Lee KY,Lee HS,Lee HK,Lee SI

doi

10.3349/ymj.1996.37.1.52

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

52-8

issue

1

eissn

0513-5796

issn

1976-2437

journal_volume

37

pub_type

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