Abstract：
:This study was performed to investigate the potential protective effect of OKY-046, an inhibitor of thromboxane A2 synthetase, on the viability of 24-hr preserved canine segmental pancreas graft. Each graft was preserved in either cold Euro-Collins (E-C) solution (control group; n = 5) or E C+OKY-046(10(-4)M) solution (OKY-046 group; n = 5). In both groups, grafts were preserved for 24 hr and calculated the total levels of 6keto-prostaglandin F1 alpha (6ket-PGF1 alpha) and thromboxane B2(TxB2) in the preservation solution per pancreas graft weight at the time point of 0,3,7,12,24 hr after preservation. The efficacy of OKY-046 in protecting ischemically stressed grafts was examined by histological findings of the grafts before transplantation and blood flow of the transplanted pancreas graft. During 24-hr preservation time, increased production of 6ket-PGF1 alpha and decreased production of TxB2 were found in OKY-046 group. Histologically ischemic damage of the acinar cells was observed in the control group, but it was milder in the OKY-046 group. The blood flow of the transplanted pancreas in the OKY-046 group were higher than that in control group. In the OKY-046 group, all dogs survived with functioning grafts, although some grafts were lost in the control group. These results suggest that there is a possibility that OKY-046 may contribute to the improvement of the survival rate in segmental pancreas transplantation.
journal_name
Int Surgjournal_title
International surgeryauthors
Nagami H,Tamura K,Kin S,Teramoto M,Ishida Tsubject
Has Abstractpub_date
1995-07-01 00:00:00pages
274-7issue
3eissn
0020-8868issn
2520-2456journal_volume
80pub_type
杂志文章abstract：:Pancreaticoduodenectomy is considered the standard operation for periampullary tumors. Despite major advances in pancreatic surgery, pancreatic fistula is still an important cause of morbidity and mortality after pancreaticoduodenectomy. Meticulous surgical technique and proper reconstruction of the pancreas are essen...
journal_title：International surgery
pub_type： 杂志文章
doi：10.9738/INTSURG-D-14-00095.1
更新日期：2015-02-01 00:00:00
abstract：:Charnley's compression clamps have hastened the union of cancellous bones but not much success has been obtained in the slender shafts of cortical bones. The principles of biophysics show that a fracture site under compression acts as a hinge joint. If friction is increased in such "joints" along indicated axes, immob...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Among the causes of male infertility, the varicocele accounts for 40%. Videolaparoscopic varicocelectomy was used for the treatment of 800 men as day surgery cases. The operation enabled high bilateral ligation, with an average operating time of 1.5 hours. Operative difficulties were minor being colon adhesions, vascu...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:The aim of this study was to retrospectively evaluate the outcome of stapled, functional, end-to-end anastomosis (FEEA) for the reconstruction of right hemicolectomy. We enrolled 204 patients who underwent a right hemicolectomy for colon carcinomas or adenomas by open surgery. One hundred two patients received an FEEA...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND:Hydatid disease of the liver remains an important and challenging problem in rural areas. Although, surgery is considered the treatment of choice for hydatid disease of the liver, percutaneous drainage is an alternative treatment method for selected cases. The purpose of this study was to evaluate the result...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1998-10-01 00:00:00
abstract：BACKGROUND:Traumatic rupture of thoracic aorta caused by blunt trauma has been observed more frequently in recent years. The aim of this study was to evaluate the state of the art of diagnostic methods used to identify this injury and the surgical techniques used to repair it. METHODS:The study was performed in 29 pat...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:In 17 years we have performed 6,505 neurosurgical procedures in the neurosurgical unit of the Salisbury Hospital Group. Only 62% were performed on Africanpatients and 38% on European patients, despite the fact that the African population exceeds the European population by 20 times. This is partly due to the tolerance ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1975-05-01 00:00:00
abstract：:The authors performed a total of 237 endolaser treatments for insufficiency of great and small saphenous veins and assessed 5-year results. It was found that this method, especially if performed with a 1470-nm-wavelength laser combined with instrumental removal of some lateral veins, was very effective. It was delicat...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：:Cases with concurrent pheochromocytoma and renal artery stenosis, two "surgically curable" hypertensive disorders, are rare. The stenosis is generally secondary to direct compression or stretching of the renal artery by the tumor. Five such cases are reported. Sometimes the tumor and the renal artery stenosis occur in...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1985-04-01 00:00:00
abstract：:Duodenoscopic sphincterotomy (DS) is a well established treatment for common bile duct (CBD) stones in post-cholecystectomy patients, but not in patients with gallbladder in situ. The main argument against the procedure in the latter set of patients has been that by performing it, one is leaving behind the diseased ga...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:The diagnosis and management of ovarian hemorrhage complicating anticoagulant therapy is discussed and a case presented. The patient, who had undergone mitral valve replacement and was receiving chronic anticoagulation treatment, was admitted with signs of intraperitoneal bleeding from a ruptured ovarian hematoma. Thi...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1982-10-01 00:00:00
abstract：:Many patients die each year lacking only a functional small bowel to survive. The minimum amount of small intestinal absorptive surface required to sustain life varies from patient to patient. Prolonged survival with oral alimentation alone has been reported in a few patients with an intact duodenum and as little as 1...
journal_title：International surgery
pub_type： 杂志文章,评审
doi：
更新日期：1999-10-01 00:00:00
abstract：:The management of the stenosis of the pancreaticojejunostomy is dictated by the state of the anastomosis and the residual pancreas, endocrine, and exocrine pancreatic function. We report a case of a 23-year-old woman who presented with recurrent attacks of acute pancreatitis. Four years ago, she was diagnosed with pan...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2008-05-01 00:00:00
abstract：:We operated on 138 patients for intestinal obstruction. The different causes are discussed and their pattern of occurrence is compared with that reported from England and other African countries. The 27.6% mortality rate was closely associated with the 28.2% incidence of gangrene. Factors which may lower this high mor...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1976-04-01 00:00:00
abstract：:Hemobilia is the process of bleeding into the biliary tree and is an unusual cause of upper gastrointestinal hemorrhage. When this event results from a cystic artery pseudoaneurysm, it is a particularly rare phenomenon; fewer than 20 cases are described in the literature. Alongside the literature review, we report a c...
journal_title：International surgery
pub_type： 杂志文章,评审
doi：10.9738/CC52.1
更新日期：2012-04-01 00:00:00
abstract：:The aim of this study is to analyze the risk factors for complications and recurrence in pilonidal sinus disease. The prospective study consisted of 144 patients with pilonidal sinus disease who were operated on at Dicle University Medical Faculty, Department of General Surgery, between February 2008 and December 2010...
journal_title：International surgery
pub_type： 杂志文章
doi：10.9738/CC86.1
更新日期：2012-07-01 00:00:00
abstract：:In an attempt to assess the different methods of treatment of tumors of the esophagus we contacted 170 surgeons (in 1975-1976). Seventy-six (45%) answered a questionnaire concerning the surgical management of esophageal tumors, the reasons for non operability and non resectability, the place of radiotherapy, the valid...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
abstract：:Endoscopic retrograde pancreatogram (ERP) has been recommended in patients with suspected pancreatic fistula to visualize the fistula tract and the ductal anatomy. Recently we have treated five men with chronic alcoholic pancreatitis complicated by pancreaticopleural or pancreaticoperitoneal fistula. The limited value...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:Transesophageal echocardiography (TEE) has been established as a very valuable asset for patient monitoring during cardiac surgery. The value of perioperative TEE for patients undergoing noncardiac surgery is less clear. This article reviews the technical aspects of TEE and comments on the potential benefit of using T...
journal_title：International surgery
pub_type： 杂志文章,评审
doi：10.9738/CC61.1
更新日期：2012-01-01 00:00:00
abstract：:Primary carcinoma of the male urethra accounts for less than 1% of malignancies in men. Mucinous adenocarcinoma of the urethra is extremely rare, and its biologic behavior is poorly understood. We present herein a rare case of mucinous urethral adenocarcinoma in a male patient with longstanding ulcerative colitis and ...
journal_title：International surgery
pub_type： 杂志文章
doi：10.9738/INTSURG-D-13-00073.1
更新日期：2014-09-01 00:00:00
abstract：:Early diagnosis of intersex is essential to avoid indecision and to establish the correct sex of rearing before mistakes have been made. Diagnosis of adrenogenital syndrome is singularly important for delay in diagnosis may lead to stunted growth or death from electrolyte imbalance. All others except the hormonally in...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1975-02-01 00:00:00
abstract：:Preoperative hyperthermo-chemo-radiotherapy (HCR) has been performed on patients with esophageal carcinoma, especially in advanced cases with invasion to the neighbouring structures (a3 carcinoma), and is considered to have contributed to the favorable postoperative prognosis. 163 patients with operated locally advanc...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:This case history re-emphasizes the absolute necessity for all cases of leukokoria or opaque media, where a view of the fundus is impossible, to have preliminary "A" or "B" scan ultrasonography. In 1960 perhaps only two or three institutions had the high resolution "B" scan equipment at their disposal. Today at least ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1978-09-01 00:00:00
abstract：:Catheter-related nosocomial urinary tract infection in postoperative orthopedic and trauma patients was studied prospectively using nitrofuroxone-impregnated urinary catheters (study group) and regular silicone-coated Foley catheters. Fifty adults in each group were randomly assigned. In Group A, antibiotic-impregnate...
journal_title：International surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2003-07-01 00:00:00
abstract：:Acute pancreatitis was induced in 139 Wistar rats by injection of trypsin in the common bilio-pancreatic duct. Peritoneal dialysis was performed in 93 rats. In some of these rats, aprotinin (250,000 UI/L) was added to the lavage fluid. Macroscopically, we noted the amount of steatonecrosis, pulmonary congestion and pl...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:The activities of cathepsin B, D and G, and their distribution in the walls of normal aorta and those of aneurysms of abdominal aorta were studied. The immunohistochemical reaction for these cathepsins was positive in the aneurysm wall both in the cells and in the extracellular matrix. It was more apparent than in nor...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:Over a one year period (June 1992-June 1993), 260 patients (208 females and 52 males) with mean age of 37 years (range 13-80), underwent laparoscopic cholecystectomy (LC) for symptomatic gallstones. Thirty patients were admitted as emergency (20 acute cholecystitis, 10 acute pancreatitis). The procedure was performed ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：:Paragangliomas or chemodectomas are neoplasms that arise from neural crest cells and histologically resemble their adrenal counterpart, the pheochromocytoma. Seventy-one percent of the extra-adrenal paragangliomas are located in the superior or inferior para-aortic area. This tumor usually presents as an abdominal mas...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:A new classification of proximal bile duct tumors mainly based on endo- and exobiliary neoplastic invasion, indicating radical or palliative surgery is proposed. Fifty-eight patients underwent radical (12) or palliative (46) surgery. The 5-year survival rate of patients treated radically is 40% compared to 0% in patie...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Breast conserving treatment (BCT) is an alternative to mastectomy, and prospective randomized trials have demonstrated that BCT and radical mastectomy result in similar actuarial survival rates. BCT should fulfil two criteria: (1) it should afford the same local control of disease as radical mastectomy, and (2) it sho...
journal_title：International surgery
pub_type： 杂志文章,评审
doi：
更新日期：1994-04-01 00:00:00
