Abstract:
:Experiments were carried out to correlate the cytological localization of DNA polymerase alpha with the presence of its specific mRNA in human lymphocytes studied at different times after phytohaemagglutinin stimulation. Our data indicated that in resting cells it is not possible to detect DNA polymerase alpha protein or mRNA by Northern hybridization. By contrast, in stimulated cells the detection of mRNA specific for DNA polymerase alpha synthesis is possible after 16 h phytohaemagglutin stimulation, whereas immunolocalization is possible after only 4 h stimulation. Observation of cytological preparations from cells stimulated for times long enough to obtain mitoses surprisingly showed an intense immunoreaction in mitotic chromosomes treated with monoclonal antibodies to DNA polymerase alpha.
journal_name
Heredity (Edinb)journal_title
Heredityauthors
Ennas MG,Suzuki H,Menegazzi M,Carcereri A,Hanaoka F,Gremo F,Nieddu M,Mezzanotte Rdoi
10.1038/hdy.1996.123subject
Has Abstractpub_date
1996-08-01 00:00:00pages
186-91eissn
0018-067Xissn
1365-2540journal_volume
77 ( Pt 2)pub_type
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