Effects of adenosine tetraphosphate (ATPP) on vascular tone in the isolated rat aorta.


:Effects of a platelet-released, naturally occurring nucleotide, adenosine 5'-tetraphosphate (ATPP) on vascular tone were analyzed in the isolated rat aorta. Under resting tension ATPP (1 approximately 100 microM) elicited concentration-dependent contractions in endothelium-intact aortic rings in contrast to the concentration-dependent relaxation with ATP. In endothelium-denuded aortic rings, ATPP induced contraction, as ATP did, but with a greater potency. alpha, beta-methylene ATP (APCPP 50 microM), a P2x-purinoceptor antagonist, significantly inhibited ATPP- as well as ATP-induced contractions in the endothelium-denuded preparations suggesting that ATPP acts via P2x-purinoceptors. ATPP (10 approximately 100 microM) relaxed precontracted aortic rings with an intact endothelium in a concentration-dependent manner. This effect of ATPP was 3.7 fold less potent than that of ATP. However, after P2x-purinoceptor blockade, the effect became identical between the two nucleotides. Reactive blue 2, a selective antagonist of P2x-purinoceptors, significantly attenuated the ATPP-induced relaxation with no change in the ATP-induced relaxation. These results indicated that the rat aortic endothelium contains heterogeneous populations of P2-purinoceptors (possibly P2y and nucleotide receptors). Since ATPP shows dual effects depending upon the vascular tension, it may play a significant role in the physiological regulation of vascular tone.


Yonsei Med J


Yonsei medical journal


Lee JW,Kong ID,Park KS,Jeong SW




Has Abstract


1995-12-01 00:00:00












  • Hemodynamical assessment of cavernous hemangioma in cavernous sinus using MR-DSA and conventional DSA.

    abstract::We report a hemodynamical assessment of the blood turnover pattern as well as the imaging of cavernous hemangioma in a cavernous sinus using time-resolved contrast enhanced 2D projection MRA, also known as MR-DSA, and conventional digital subtraction angiography (DSA), before and after radiotherapy. MR-DSA showed very...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Shim YW,Chung TS,Kang WS,Lee KS,Strecker R,Hennig J

    更新日期:2003-10-30 00:00:00

  • Malignant granular cell tumor at the retrotracheal space.

    abstract::We report a case of an extremely rare neoplasm, malignant granular cell tumor (MGCT). The patient was a 21-year-old woman, who was 5 months pregnant. The tumor occurred in the retrotracheal space, extending from the level of the larynx to the thoracic inlet. In addition, there were multiple, variable-sized tumor nodul...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Yang SW,Hong SW,Cho MY,Kang SJ

    更新日期:1999-02-01 00:00:00

  • Angiotensinogen and angiotensin II type 1 receptor gene polymorphism in patients with autosomal dominant polycystic kidney disease: effect on hypertension and ESRD.

    abstract::Autosomal dominant polycystic kidney disease (ADPKD), a common genetic disease, is characterized by the development of hypertension and end stage renal disease. An increase in the activity of the renin-angiotensin system, due to a renal ischemia caused by cyst expansion, contributes to the development of hypertension ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Lee KB,Kim UK

    更新日期:2003-08-30 00:00:00

  • Clinical Implications of Moderate Coronary Stenosis on Coronary Computed Tomography Angiography in Patients with Stable Angina.

    abstract:PURPOSE:The present study investigated the diagnostic accuracy and clinical implications of moderate stenosis (50-69%, Coronary Artery Disease Reporting and Data System, grade 3) on coronary computed tomography angiography (CCTA), compared with invasive coronary angiography (ICA). MATERIALS AND METHODS:Two hundred and...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Kim C,Hong SJ,Ahn CM,Kim JS,Kim BK,Ko YG,Choi BW,Choi D,Jang Y,Hong MK

    更新日期:2018-10-01 00:00:00

  • Specially programmed respiratory muscle training for singers by using respiratory muscle training device (Ultrabreathe).

    abstract::Respiratory muscle training is one of the major methods for enhancing the vocal function. Singers who must use their voice most frequently are well aware of the importance of respiration. However, most of them do not know precisely how to exercise their abdominal respiration. Using a respiratory training device, singe...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Nam DH,Lim JY,Ahn CM,Choi HS

    更新日期:2004-10-31 00:00:00

  • Extracellular Vesicles Derived from Hypoxic Human Mesenchymal Stem Cells Attenuate GSK3β Expression via miRNA-26a in an Ischemia-Reperfusion Injury Model.

    abstract:PURPOSE:Bioactive molecules critical to intracellular signaling are contained in extracellular vesicles (EVs) and have cardioprotective effects in ischemia/reperfusion (IR) injured hearts. This study investigated the mechanism of the cardioprotective effects of EVs derived from hypoxia-preconditioned human mesenchymal ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Park H,Park H,Mun D,Kang J,Kim H,Kim M,Cui S,Lee SH,Joung B

    更新日期:2018-08-01 00:00:00

  • Alcoholism prevalence and some related factors in Edirne, Turkey.

    abstract::The aim of this research was to estimate the community prevalence of alcoholism and the potential risk factors that affect it in the Edirne provincial centre by using a scanning test. A cross-sectional study was carried out in the Edirne provincial centre. A sample population composed of 500 women and 200 men was sele...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Ekuklu G,Deveci S,Eskiocak M,Berberoglu U,Saltik A

    更新日期:2004-04-30 00:00:00

  • Lactobacillus casei subspecies casei endocarditis--a case report.

    abstract::Lactobacillus sp., generally considered to be a harmless indigenous bacteria of the mucous membrane, occasionally causes serious infections. Lactobacillus endocarditis is a very rare disease, and no case has been reported in Korea. Gram-positive bacilli were isolated from blood cultures of a 41-year-old man with clini...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Chong Y,Lim HS,Lee SY,Cho SY

    更新日期:1991-03-01 00:00:00

  • A case of primary bilateral adrenal lymphoma (PAL) with central nervous system (CNS) involvement.

    abstract::Primary adrenal lymphoma (PAL) is a very rare disease and usually does not have disease elsewhere, and if present, it is frequently extranodal. Several cases of PALs, with central nervous system (CNS) involvement, gastrointestinal tract or other endocrine organs involvement, have been reported in Western literature. W...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Hahn JS,Choi HS,Suh CO,Lee WJ

    更新日期:2002-06-01 00:00:00

  • Real-time determination of left ventricular ejection fraction by automatic boundary detection in patients with dilated cardiomyopathy: a comparison with radionuclide ventriculography.

    abstract::Echocardiographic automatic boundary detection (ABD) is a new on-line technique which automatically outlines the left ventricular endocardial border and instantly calculates the left ventricular area and volume from two dimensional echocardiographic images. To determine if left ventricular ejection fraction (LVEF) can...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Ha JW,Chung N,Choe KH,Kwan J,Rim SJ,Jang Y,Kim JY,Oh EK,Lee YJ,Shim WH,Cho SY,Kim SS

    更新日期:1996-12-01 00:00:00

  • A clinicopathological study of Kimura's disease and epithelioid hemangioma.

    abstract::The clinicopathological features of 9 cases of Kimura's disease and 5 cases of epithelioid hemangioma(EH) were reviewed. Patients with Kimura's disease presented with multiple or solitary large tumors occurring in the thigh, arms as well as parotid gland. Histologically, the lesions were characterized by numerous lymp...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Ahn HJ,Lee KG

    更新日期:1990-09-01 00:00:00

  • Heat contact urticaria--a case report.

    abstract::Heat contact urticaria is very rare and it is characterized by the development of wheal limited to the areas of heat contact. We report a case of heat contact urticaria in a 65-year-old women. The wheal was induced by hot bathing, washing in hot water or leaning on hot radiators. Symptoms started within 5 minutes of e...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Chung HS,Lee KH,Ro JY

    更新日期:1996-06-01 00:00:00

  • Microsatellite marker in gamma - aminobutyric acid - a receptor beta 3 subunit gene and autism spectrum disorders in Korean trios.

    abstract::This study aimed to identify the association between gamma-aminobutyric acid-A (GABA-A) receptor subunit beta3 (GABRB3) gene and autism spectrum disorders (ASD) in Korea. Fifty-eight children with ASD [47 boys (81.0%), 5.5 +/- 4.1 years old], 46 family trios, and 86 healthy control subjects [71 males (82.6%), 33.6 +/-...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Yoo HK,Chung S,Hong JP,Kim BN,Cho SC

    更新日期:2009-04-30 00:00:00

  • Reliability of RTVue, Visante, and slit-lamp adapted ultrasonic pachymetry for central corneal thickness measurement.

    abstract:PURPOSE:To evaluate reliability of Fourier-domain optical coherence tomography (OCT) (RTVue), time-domain OCT (Visante), and slit-lamp adapted ultrasonic pachymetry (SL-US) in the measurement of central corneal thickness (CCT). MATERIALS AND METHODS:Thirty healthy volunteers visited our clinic 3 times and fifty eyes w...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Hong JP,Nam SM,Kim TI,Seo KY,Lee SY,Meduri A,Kim EK

    更新日期:2012-05-01 00:00:00

  • mTOR Signaling Combined with Cancer Stem Cell Markers as a Survival Predictor in Stage II Colorectal Cancer.

    abstract:PURPOSE:Wnt and mammalian target of rapamycin (mTOR) are major molecular signaling pathways associated with the development and progression of tumor, as well as the maintenance and proliferation of cancer stem cells (CSCs), in colorectal cancer (CRC). Identifying patients at risk of poor prognosis is important to deter...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Chang JY,Kim JH,Kang J,Park Y,Park SJ,Cheon JH,Kim WH,Kim H,Park JJ,Kim TI

    更新日期:2020-07-01 00:00:00

  • Correlation between EGFR and c-erbB-2 oncoprotein status and response to neoadjuvant chemotherapy in cervical carcinoma.

    abstract::Neoadjuvant chemotherapy prior to definitive radical surgery or radiotherapy may be effective in reducing tumor volume or clinical stage and may even enhance pelvic control and survival. However, there are significant limitations to the use of neoadjuvant therapy in the non-responder group. They include delayed total ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Kim JW,Kim YT,Kim DK

    更新日期:1999-06-01 00:00:00

  • Effects of epithelium on the mechanism of mediator release from guinea pig tracheal tissues sensitized by IgG1 versus IgE antibody.

    abstract::In the present work, we have examined the effect of PAF, removal of epithelium, the mechanism of desensitization, and the substances that increases the level of intracellular c-AMP on the differences of mediator release from superfused tracheal strips after passive sensitization with IgG1 versus IgE Ab. In the passive...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Ro JY,Kim KH

    更新日期:1995-05-01 00:00:00

  • Evaluation of the UniCel™ DxI 800 immunoassay analyzer in measuring five tumor markers.

    abstract:PURPOSE:Tumor marker concentrations in a given specimen measured by different analyzers vary according to assay methods, epitopes for antibodies used, and reagent specificities. Although great effort in quality assessment has been instituted, discrepancies among results from different analyzers are still present. We ev...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Park Y,Park Y,Park J,Kim HS

    更新日期:2012-05-01 00:00:00

  • Is an Isolated Weight-Holding Tremor a New Subtype of Isometric Tremor?

    abstract::A weight-holding tremor is a rare type of hand tremor that occurs only when someone holds some weight. Here we report three cases of isolated weight-holding tremors, of which one patient was diagnosed with Parkinson's disease (PD) and the others as a variant of essential tremor (ET). A 68-year-old woman presented with...

    journal_title:Yonsei medical journal



    authors: Yong SW,Park DG,Yoon JH,Baik JS

    更新日期:2020-07-01 00:00:00

  • Production of egg yolk antibodies specific to house dust mite proteins.

    abstract:PURPOSE:House dust mites (HDMs) are an important source of indoor allergens associated with asthma, rhinitis and atopic dermatitis. Chicken immunoglobulin (Ig) Y is known to be a good alternative to mice and rabbit antibody production. In this study, we produced IgYs specific to HDMs and investigated their IgE immunore...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Lee KE,Han BK,Han JY,Hong JY,Kim MN,Heo WI,Sohn MH,Kim KW,Kim KE

    更新日期:2014-07-01 00:00:00

  • Long-Term Outcome and Surveillance Colonoscopy after Successful Endoscopic Treatment of Large Sessile Colorectal Polyps.

    abstract:PURPOSE:Although there is a consensus about the need for surveillance colonoscopy after endoscopic resection, the interval remains controversial for large sessile colorectal polyps. The aim of this study was to evaluate the long-term outcome and the adequate surveillance colonoscopy interval required for sessile and fl...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Kim B,Choi AR,Park SJ,Cheon JH,Kim TI,Kim WH,Hong SP

    更新日期:2016-09-01 00:00:00

  • Ultrastructural changes of the external elastic lamina in experimental hypercholesterolemic porcine coronary arteries.

    abstract::The external elastic lamina (EEL) serves as a barrier for cells and macromolecules between the media and adventitia in the vascular wall. We evaluated the morphological changes and quantitative assessments of the EEL architecture in the coronary circulation of pigs fed with a high cholesterol diet. Confocal microscopy...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Kwon HM,Kang S,Hong BK,Kim D,Park HY,Shin MS,Byun KH

    更新日期:1999-06-01 00:00:00

  • Validation of the Korean Version of the Spatial Hearing Questionnaire for Assessing the Severity and Symmetry of Hearing Impairment.

    abstract:PURPOSE:Spatial hearing refers to the ability to understand speech and identify sounds in various environments. We assessed the validity of the Korean version of the Spatial Hearing Questionnaire (K-SHQ). MATERIALS AND METHODS:We performed forward translation of the original English SHQ to Korean and backward translat...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Kong TH,Park YA,Bong JP,Park SY

    更新日期:2017-07-01 00:00:00

  • Association of plasma retinol-binding protein 4, adiponectin, and high molecular weight adiponectin with insulin resistance in non-diabetic hypertensive patients.

    abstract:PURPOSE:The aim of this study was to determine whether retinol-binding protein 4 (RBP4), adiponectin and high molecular weight (HMW) adiponectin are associated with insulin resistance (IR) and metabolic parameters in non-diabetic hypertensive patients. Also, we sought to compare the predictive values of these adipocyto...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Shim CY,Park S,Kim JS,Shin DJ,Ko YG,Kang SM,Choi D,Ha JW,Jang Y,Chung N

    更新日期:2010-05-01 00:00:00

  • Chorea following acute carbon monoxide poisoning.

    abstract::The clinical cases of 6 patients suffering with chorea after acute carbon monoxide (CO) poisoning were reviewed. There were 2 men and 4 women, and the age at onset ranged from 11 to 60 (mean 33.0) years. All the patients except one were associated with mild delayed CO encephalopathy. The latency period between CO pois...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审


    authors: Park S,Choi IS

    更新日期:2004-06-30 00:00:00

  • Expression of hepatitis C virus core protein in hepatocytes does not modulate proliferation or apoptosis of CD8+ T cells.

    abstract::Hepatocytes are the primary targets of the hepatitis C virus (HCV). While immunosuppressive roles of HCV core protein have been found in several studies, it remains uncertain whether core protein expressed in hepatocytes rather than in immune cells affects the CD8+ T cell response. In order to transduce genes selectiv...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Jin YH,Crispe IN,Park S

    更新日期:2005-12-31 00:00:00

  • Identification of Tyrophagus putrescentiae allergens and evaluation of cross-reactivity with Dermatophagoides pteronyssinus.

    abstract::House dust mites are the most common cause of allergic sensitization in respiratory allergic patients in the world. Tyrophagus putrescentiae (TP), which was followed by Dermatophagoides farinae (DF) and Dermatophagoides pteronyssinus (DP), has been reported as the third most common house mite in Korea. We previously r...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Munhbayarlah S,Park JW,Ko SH,Ree HI,Hong CS

    更新日期:1998-04-01 00:00:00

  • Leptin as a modulator of neuroendocrine function in humans.

    abstract::Leptin, a peptide hormone secreted by adipocytes in proportion of the amount of energy stored in fat, plays a central role in regulating human energy homeostasis. In addition, leptin plays a significant permissive role in the physiological regulation of several neuroendocrine axes, including the hypothalamic-pituitary...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审


    authors: Khan SM,Hamnvik OP,Brinkoetter M,Mantzoros CS

    更新日期:2012-07-01 00:00:00

  • The relationship between aldosterone to renin ratio and RI value of the uterine artery in the preeclamptic patient vs. normal pregnancy.

    abstract:PURPOSE:Plasma levels of renin, angiotensin II and aldosterone are increased during normal pregnancy. However, these values in preeclampsia are decreased to nearly that of a nonpregnant subject, and vascular sensitivity to angiotensin II is increased. In preeclampsia, aldosterone is decreased less than rennin. Therefor...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章


    authors: Kim EH,Lim JH,Kim YH,Park YW

    更新日期:2008-02-29 00:00:00

  • Disruption of the Gut Ecosystem by Antibiotics.

    abstract::The intestinal microbiota is a complex ecosystem consisting of various microorganisms that expands human genetic repertoire and therefore affects human health and disease. The metabolic processes and signal transduction pathways of the host and intestinal microorganisms are intimately linked, and abnormal progression ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审


    authors: Yoon MY,Yoon SS

    更新日期:2018-01-01 00:00:00