Abstract:
:The natural dibenzylbutyrolactone type lignanolide (-)-arctigenin (2), an inhibitor of human immunodeficiency virus type-1 (HIV-1) replication in infected human cell systems, was found to suppress the integration of proviral DNA into the cellular DNA genome. In the present study 2 was tested with purified HIV-1 integrase and found to be inactive in the cleavage (3'-processing) and integration (strand transfer) assays. However, the semisynthetic 3-O-demethylated congener 9 characterized by a catechol substructure exhibited remarkable activities in both assays. Structure-activity relationship studies with 30 natural (1-6), semisynthetic (7-21), and synthetic (37-43, 45, 46) lignans revealed that (1) the lactone moiety is crucial since compounds with a butane-1,4-diol or tetrahydrofuran substructure and also lignanamide analogues lacked activity and (2) the number and arrangement of phenolic hydroxyl groups is important for the activity of lignanolides. The congener with two catechol substructures (7) was found to be the most active compound in this study. 7 was also a potent inhibitor of the "disintegration" reaction which models the reversal of the strand transfer reaction. The inhibitory activity of 7 with the core enzyme fragment consisting of amino acids 50-212 suggests that the binding site of 7 resides in the catalytic domain.
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Eich E,Pertz H,Kaloga M,Schulz J,Fesen MR,Mazumder A,Pommier Ydoi
10.1021/jm950387usubject
Has Abstractpub_date
1996-01-05 00:00:00pages
86-95issue
1eissn
0022-2623issn
1520-4804pii
jm950387ujournal_volume
39pub_type
杂志文章abstract::Novel classes of antimalarial drugs are needed due to emerging drug resistance. Azithromycin, the first macrolide investigated for malaria treatment and prophylaxis, failed as a single agent and thus novel analogues were envisaged as the next generation with improved activity. We synthesized 42 new 9a-N substituted 15...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm201615t
更新日期:2012-02-09 00:00:00
abstract::A series of derivatives of the antimycobacterial natural product pyridomycin have been prepared with the C2 side chain attached to the macrocyclic core structure by a C-C single bond, in place of the synthetically more demanding enol ester double bond found in the natural product. Hydrophobic C2 substituents of suffic...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/acs.jmedchem.9b01457
更新日期:2020-02-13 00:00:00
abstract::Natural product rakicidin A induces cell death in TKI-resistant chronic myelogenous leukemia (CML) cells. Therefore, 14 rakicidin A analogues were synthesized via a highly efficient combinatorial strategy and were evaluated against CML cell lines. The conjugated diene moiety was found to be crucial for the anti-CML ac...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/acs.jmedchem.5b01841
更新日期:2016-02-11 00:00:00
abstract::Esophageal adenocarcinoma (EAC) is a molecularly heterogeneous disease that is rising rapidly in incidence and has poor prognosis. We developed a heterobivalent peptide to target detection of early Barrett's neoplasia by combining monomer heptapeptides specific for either EGFR or ErbB2 in a heterodimer configuration. ...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/acs.jmedchem.8b00405
更新日期:2018-06-28 00:00:00
abstract::HCV infection is considered a silent epidemic because most people infected do not develop acute symptoms. Instead, the disease progresses to a chronic state leading to cirrhosis and hepatocarcinoma. Novel therapies are needed to combat this major health threat. The HCV NS3 serine protease has been the target of contin...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm801201u
更新日期:2009-02-12 00:00:00
abstract::The linear interaction energy method with continuum electrostatics (LIECE) is evaluated in depth on five kinases. The two multiplicative coefficients for the van der Waals energy and electrostatic free energy are shown to be transferable among different kinases. Moreover, good enrichment factors are obtained for a lib...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm070654j
更新日期:2008-03-13 00:00:00
abstract::In our continuing study of triterpene derivatives as potent anti-HIV agents, different C-3 conformationally restricted betulinic acid (BA, 1) derivatives were designed and synthesized in order to explore the conformational space of the C-3 pharmacophore. 3-O-Monomethylsuccinyl-betulinic acid (MSB) analogues were also ...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm901782m
更新日期:2010-04-22 00:00:00
abstract::Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as the pathologic hallmark of several neurodegenerative diseases including Alzheimer's disease. In vivo detection of NFTs using PET imaging represents a unique opportunity to develop a pharmacodynamic tool to accelerate the discovery...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/acs.jmedchem.6b00166
更新日期:2016-05-26 00:00:00
abstract::1-(Benzoyloxy), 1-(4-nitrobenzoyloxy), and 1-(3,5-dinitrobenzoyloxy) derivatives of 3-fluoro-, 3-chloro-, and 3-bromopropan-2-one were prepared by oxidation of the 1-benzoyloxy-3-halopropan-2-ols in turn prepared from the appropriate benzoyl chloride and 3-halo-1,2-propanediols, 1-Benzoyloxy-3-fluoropropan-2-one was a...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00215a005
更新日期:1977-05-01 00:00:00
abstract::Elevated plasma levels of low-density lipoprotein (LDL) cholesterol are a major risk factor for atherosclerosis leading to coronary artery disease (CAD), which remains the main cause of mortality in Western society. We believe that by preventing the reabsorption of bile acids, a minimally absorbed apical sodium-codepe...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm040215+
更新日期:2005-09-08 00:00:00
abstract::We describe the design, synthesis, and evaluation of novel disubstituted cyclohexanes as potent CCR2 antagonists. Exploratory SAR studies led to the cis-disubstituted derivative 22, which displayed excellent binding affinity for CCR2 (binding IC50 = 5.1 nM) and potent functional antagonism (calcium flux IC50 = 18 nM a...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm701488f
更新日期:2008-02-28 00:00:00
abstract::We present a novel protein-ligand docking method that accurately accounts for both ligand and receptor flexibility by iteratively combining rigid receptor docking (Glide) with protein structure prediction (Prime) techniques. While traditional rigid-receptor docking methods are useful when the receptor structure does n...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm050540c
更新日期:2006-01-26 00:00:00
abstract::N6-isopentenyladenosine (i6A), a modified nucleoside belonging to the cytokinin family, has shown in humans many biological actions, including antitumoral effects through the modulation of the farnesyl pyrophosphate synthase (FPPS) activity. To investigate the relationship between i6A and FPPS, we undertook an inverse...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm500869x
更新日期:2014-09-25 00:00:00
abstract::The discovery of a series of novel halogenated arylsulfonamides (HAS) as new sigma receptor binding tumor imaging agents is described. Several substituted halogenated sulfonamides have been prepared and characterized. Target compounds were examined for their affinity for sigma1 and sigma2 receptor subtypes using guine...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm9800447
更新日期:1998-07-02 00:00:00
abstract::Selective inhibition of the isoforms of nitric oxide synthase (NOS) in pathologically elevated synthesis of nitric oxide has great therapeutic potential. We previously reported nitroarginine-containing dipeptide amides and some peptidomimetic analogues as potent and selective inhibitors of neuronal NOS (nNOS). Here we...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm030297m
更新日期:2004-01-29 00:00:00
abstract::The histamine H4 receptor (H4R), a member of the G-protein coupled receptor family, has been considered as a potential therapeutic target for treating atopic dermatitis (AD). A large number of H4R antagonists have been disclosed, but no efficient agents controlling both pruritus and inflammation in AD have been develo...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/acs.jmedchem.7b01855
更新日期:2018-04-12 00:00:00
abstract::The effects of addition of a methyl group to a lead compound on biological activity are examined. A literature analysis of >2000 cases reveals that an activity boost of a factor of 10 or more is found with an 8% frequency, and a 100-fold boost is a 1 in 200 event. Four cases in the latter category are analyzed in dept...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm3003697
更新日期:2012-05-10 00:00:00
abstract::The subject compounds were prepared as a part of a continuing structure-activity study of the contrasting actions (agonism-antagonism) of (+)- and (-)-11-hydroxy-10-methylaporphine at serotonin (5-HT1A) receptors. None of the targeted nonoxygenated aporphine derivatives demonstrated significant activity in assays for ...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00062a002
更新日期:1993-05-14 00:00:00
abstract::The synthesis and some biological activities of [4-beta-(2-thienyl)-L-alanine]oxytocin are reported. This analogue has been studied in an ongoing exploration of the biological effects of introducing amino acid residues with bulky hydrophobic side chains into the second corner position of the beta turn present in the c...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00199a022
更新日期:1978-01-01 00:00:00
abstract::The ability of a series of substituted kynurenic acids, thienopyridinonecarboxylic acids, and related compounds to inhibit the binding of nerve growth factor (NGF) to the p75 NGF receptor (NGFR) was evaluated in a radioligand binding assay that utilized a biotinylated derivative of the extracellular domain of p75 NGFR...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00022a008
更新日期:1995-10-27 00:00:00
abstract::4-(2-Methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole (5) is a highly potent member of a structurally novel series of selective serotonin-3 receptor antagonists. The synthesis of tritiated 5 and its binding profile in neuroblastoma-glioma 108-15 cells are described. Furthermore, in vivo studies in rat with...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00173a017
更新日期:1990-11-01 00:00:00
abstract::Dequalinium (4) is a potent and selective blocker of small conductance Ca2+-activated K+ channels, an important but relatively little studied class. The 4-NH2 group of dequalinium has been shown to contribute significantly to blocking potency. In this study, we have investigated further the role of the 4-NH2 group. Re...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00018a013
更新日期:1995-09-01 00:00:00
abstract::The binding affinities at rat A1, A2a, and A3 adenosine receptors of a wide range of derivatives of adenosine have been determined. Sites of modification include the purine moiety (1-, 3-, and 7-deaza; halo, alkyne, and amino substitutions at the 2- and 8-positions; and N6-CH2-ring, -hydrazino, and -hydroxylamino) and...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00007a014
更新日期:1995-03-31 00:00:00
abstract::Recently, we reported the identification of a novel class of pregnane-X-receptor (PXR) agonists, solomonsterols A and B, isolated from the marine sponge Theonella swinhoei. Preliminary pharmacological studies demonstrated that these natural compounds are potential leads for the treatment of human disorders characteriz...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm200241s
更新日期:2011-07-14 00:00:00
abstract::The potent inhibitory activity of novel 2-benzyltetralone and 2-benzylidenetetralone derivatives vs liver microsomal retinoic acid metabolizing enzymes and a MCF-7 CYP26A1 cell assay is described. In the liver microsomal assay, the 2-biphenylmethyl-6-hydroxytetralone derivatives 16a and 16b were found to be potent inh...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm0501681
更新日期:2005-11-17 00:00:00
abstract::Protein lysine methyltransferase G9a plays key roles in the transcriptional repression of a variety of genes via dimethylation of lysine 9 on histone H3 (H3K9me2) of chromatin as well as dimethylation of nonhistone proteins including tumor suppressor p53. We previously reported the discovery of UNC0321 (3), the most p...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm200903z
更新日期:2011-09-08 00:00:00
abstract::A computational methodology is introduced to systematically organize compound analogue series according to substitution sites and identify combinations of sites that determine structure-activity relationships (SARs) and make large contributions to SAR discontinuity. These sites are prime targets for further chemical m...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm900107b
更新日期:2009-05-28 00:00:00
abstract::Adenosine receptor-binding profiles in rat brain tissues and antihypertensive effects in spontaneously hypertensive rats (SHR) of a series of 2-(cycloalkylalkynyl)adenosines (2-CAAs) and their congeners are described. The structure-activity relationship of this series of compounds is discussed, focusing on the length ...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00090a017
更新日期:1992-06-12 00:00:00
abstract::HCV serine protease NS3 represents an attractive drug target because it is not only essential for viral replication but also implicated in the viral evasion of the host immune response pathway through direct cleavage of key proteins in the human innate immune system. Through structure-based drug design and optimizatio...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm400164c
更新日期:2014-03-13 00:00:00
abstract::We have previously reported that rhodacyanine dyes, such as 1 and 2, exhibited a potent inhibitory effect on the growth of several tumor cells and that 4-oxothiazolidine (rhodanine) was an essential moiety for antitumor activity. On the basis of our foregoing work, two types of rhodacyanine dyes, which categorized int...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm970590k
更新日期:1998-01-01 00:00:00