Abstract：
:In the present study we have examined the effects of the general anesthetic agents for the excision of the heart on the hemodynamic function of the ischemic perfused heart. Animals were divided into three groups. In one group rats were anesthetized with sodium pentobarbital intraperitoneally. Animals of the second and third groups were anesthetized with inhalation anesthetics, sevoflurane and isoflurane, respectively. The hearts were then rapidly excised and perfused by a working heart model. After control perfusion, whole-heart ischemia was induced by one-way aortic valve for 15 min followed by reperfusion for 30 min. During preischemic control period, cardiac output (CO) and left ventricular dP/dT maximum (LV dP/dT max) in the isoflurane group were significantly higher than those in the pentobarbital group. During reperfusion, CO and LV dP/dT max in the isoflurane and sevoflurane groups recovered more rapidly than those in the pentobarbital group. Although there were no significant differences in myocardial ATP and glycogen levels among the groups, myocardial lactate in the pentobarbital group was significantly higher than those in the sevoflurane and isoflurane groups. These results suggest that intraperitoneal pentobarbital anesthesia, administered prior to heart excision, may affect the performance of the ischemic perfused heart thereafter. Therefore, we would suggest that isolation of hearts by means of inhalation anesthesia is better than by means of pentobarbital in the working rat heart.
journal_name
J Pharmacol Toxicol Methodsjournal_title
Journal of pharmacological and toxicological methodsauthors
Oguchi T,Kashimoto S,Yamaguchi T,Nakamura T,Kumazawa Tdoi
10.1016/1056-8719(93)90049-ksubject
Has Abstractpub_date
1993-02-01 00:00:00pages
37-43issue
1eissn
1056-8719issn
1873-488Xpii
1056-8719(93)90049-Kjournal_volume
29pub_type
杂志文章abstract：INTRODUCTION:Epigenetic modifications, such as histone acetylation and deacetylation, are responsible for maintaining chromatin stability. As such, they have been implicated in a wide range of neurodegenerative disorders. METHODS:Histone acetylation involves the presentation of an acetyl group to lysine residues at th...
journal_title：Journal of pharmacological and toxicological methods
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journal_title：Journal of pharmacological and toxicological methods
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journal_title：Journal of pharmacological and toxicological methods
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journal_title：Journal of pharmacological and toxicological methods
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doi：10.1016/j.vascn.2012.02.001
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journal_title：Journal of pharmacological and toxicological methods
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journal_title：Journal of pharmacological and toxicological methods
pub_type： 杂志文章
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journal_title：Journal of pharmacological and toxicological methods
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更新日期：2019-01-01 00:00:00
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journal_title：Journal of pharmacological and toxicological methods
pub_type： 杂志文章
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更新日期：1998-07-01 00:00:00
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journal_title：Journal of pharmacological and toxicological methods
pub_type： 杂志文章
doi：10.1016/1056-8719(94)90048-5
更新日期：1994-04-01 00:00:00
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journal_title：Journal of pharmacological and toxicological methods
pub_type： 杂志文章
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更新日期：2014-07-01 00:00:00
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journal_title：Journal of pharmacological and toxicological methods
pub_type： 杂志文章
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journal_title：Journal of pharmacological and toxicological methods
pub_type： 杂志文章,评审
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更新日期：1994-09-01 00:00:00
