Abstract:
:Complement activation is a key component of the pathogenesis of immune-mediated tissue damage in many diseases. Assessment of complement activation in current practice is largely based on the measurement of intact C3 and C4 or the determination of complement haemolytic function. These parameters reflect activation only indirectly, are insensitive and open to influence by factors other than complement conversion. New approaches to evaluate complement activation directly using sensitive techniques have been developed, and several could be adopted easily in most laboratories. These concentrate on the detection of activation fragments, neoantigens or complexes that only arise as a direct result of complement activation. The wide application of these techniques in research and clinical practice would enhance our understanding of the pathogenesis of a range of inflammatory and infectious diseases.
journal_name
J Immunol Methodsjournal_title
Journal of immunological methodsauthors
Porcel JM,Peakman M,Senaldi G,Vergani Ddoi
10.1016/0022-1759(93)90063-dsubject
Has Abstractpub_date
1993-01-04 00:00:00pages
1-9issue
1-2eissn
0022-1759issn
1872-7905pii
0022-1759(93)90063-Djournal_volume
157pub_type
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journal_title:Journal of immunological methods
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journal_title:Journal of immunological methods
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journal_title:Journal of immunological methods
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journal_title:Journal of immunological methods
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journal_title:Journal of immunological methods
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