Allogeneic bone marrow transplantation for leukemia following piperazinedione and fractionated total body irradiation.

abstract：:We have developed a murine monoclonal antibody (mAb) specific for the delta chain of hemoglobin (Hb) A2 that does not cross-react with alpha, beta, or gamma chains. The mAb reacted with Hb P-Nilotic (beta delta hybrid), but not with Hb Lepore-Boston (delta beta hybrid), indicating an epitope consisting of positions 11...

journal_title：American journal of hematology

authors： Shyamala M,Kiefer CR,Moscoso H,Garver FA

更新日期：1991-11-01 00:00:00

abstract：:A modified protein-bound cobalamin absorption test was used to study dietary cobalamin absorption in healthy adults of different age groups and patients with isolated low serum concentrations of cobalamin. Dietary cobalamin absorption was significantly reduced in healthy adults aged 55-75 years compared with young adu...

journal_title：American journal of hematology

authors： Scarlett JD,Read H,O'Dea K

更新日期：1992-02-01 00:00:00

abstract：:Upon appropriate drug treatment, the human erythroleukemic K562 cells have been shown to produce hemoglobin and F-cells. Fetal hemoglobin (Hb F) inhibits the polymerization events of sickle hemoglobin (Hb S), thereby ameliorating the clinical symptoms of sickle cell disease. Ribonucleotide reductase inhibitors (RRIs) ...

journal_title：American journal of hematology

authors： Iyamu WE,Adunyah SE,Fasold H,Horiuchi K,Elford HL,Asakura T,Turner EA

更新日期：2000-04-01 00:00:00

abstract：:A 50-year-old woman with muscular fatigue and monoclonal gammopathy of unknown significance was shown to have high levels of antibodies against the acetylcholine receptor of the skeletal muscle endplate. The specific antibody activity was exclusively associated with the monoclonal component. There were no objective si...

journal_title：American journal of hematology

authors： Ahlberg RE,Lefvert AK

更新日期：1988-09-01 00:00:00

abstract：:Twenty-eight patients undergoing cardiac surgery were prospectively studied and were assigned to two groups. The patients received 0.8- (Group L) or 2.0-fold (Group H) dose of protamine for the neutralization after cardiopulmonary bypass (CPB) which was determined by Hepcon HMS(R) assay system in which the reagent cha...

journal_title：American journal of hematology

authors： Miyashita T,Nakajima T,Hayashi Y,Kuro M

更新日期：2000-06-01 00:00:00

abstract：:We report here the haplotypes of 10 MstII-defined SS patients and a S/beta o thalassemia from the Central African Republic, exhibiting 7 different atypical haplotypes that are different from the typical Bantu haplotype that characterize over 93% of the beta s bearing chromosomes in that region of Africa. Of the seven ...

journal_title：American journal of hematology

authors： Srinivas R,Dunda O,Krishnamoorthy R,Fabry ME,Georges A,Labie D,Nagel RL

更新日期：1988-09-01 00:00:00

abstract：:Despite advances in chemotherapeutic agents, the prognosis for some cancers remains extremely poor, suggesting the need for other treatment modalities. Immunotherapy appears an ideal approach because the mechanisms of tumor cell killing induced by tumor vaccines are different from those from chemotherapy. Various inve...

journal_title：American journal of hematology

authors： Dadabayev AR,Wang Z,Zhang Y,Zhang J,Robinson WR,Lim SH

更新日期：2005-09-01 00:00:00

abstract：:BCR-ABL1-negative myeloproliferative neoplasms (MPNs) are clonal stem cell disorders defined by proliferation of one or more myeloid lineages, and carry an increased risk of vascular events and progression to myelofibrosis and leukemia. Portal hypertension (pHTN) occurs in 7-18% of MPN patients via both thrombotic and...

journal_title：American journal of hematology

authors： Reilly CR,Babushok DV,Martin K,Spivak JL,Streiff M,Bahirwani R,Mondschein J,Stein B,Moliterno A,Hexner EO

更新日期：2017-09-01 00:00:00

abstract：:The results of chemotherapy remain unsatisfactory for many patients with advanced lymphomas. Both standard and more aggressive chemotherapy regimens might have their respective role in the management of theses diseases. We have tested the feasibility and assessed the toxicity and activity of a LNH84-derived chemothera...

journal_title：American journal of hematology

authors： Laurencet FM,Zulian GB,Bauer J,Mermillod B,Iten PA,Alberto P

更新日期：1997-08-01 00:00:00

abstract：:Community practice experience allows a nonselective care of patient using information derived from a more controlled clinical trial environment. We present our community experience with multiple myeloma patients with advanced age, long disease duration since diagnosis, advanced stage, multiple prior therapies includin...

journal_title：American journal of hematology

authors： Onitilo AA,Engel J,Olatosi B,Fagbemi S

更新日期：2007-07-01 00:00:00

abstract：:Argentine hemorrhagic fever (AHF) is a viral disease caused by Junin virus and characterized by hematologic and neurological involvement. The main hematologic features are leukopenia, thrombocytopenia, and bone marrow hypoplasia. Hematopoietic growth factors serum levels were measured by ELISA technique in forty-eight...

journal_title：American journal of hematology

authors： Marta RF,Enria D,Molinas FC

更新日期：2000-05-01 00:00:00

abstract：:A 69-year-old man with immunoblastic lymphadenopathy and autoimmune hemolytic anemia who had no previous exposure to blood products developed a severe febrile nonhemolytic transfusion reaction following the initial infusion of packed red blood cells. The reaction recurred with transfusion of packed red blood cells, bu...

journal_title：American journal of hematology

authors： Barnes HM,Poon MC,Huang ST,Conrad ME,Lin J,McGowan EI

更新日期：1983-02-01 00:00:00

abstract：:Twenty-two normal volunteers had approximately eight, 2-hr-long leukapheresis procedures over a 2-year period and their natural killer (NK) cell function was prospectively measured. The NK activity of the preprocedure peripheral blood (pre-PB) was found to correlate well with the NK activity of the inital leukocytes r...

journal_title：American journal of hematology

authors： Stevenson HC,Beman JS,Crisp B,Coggin D,Kanapa DJ,Miller P,Herberman RB,Maluish AE

更新日期：1986-06-01 00:00:00

abstract：:Thrombotic complications occur at high rates in hospitalized patients with COVID-19, yet the impact of intensive antithrombotic therapy on mortality is uncertain. We examined in-hospital mortality with intermediate- compared to prophylactic-dose anticoagulation, and separately with in-hospital aspirin compared to no a...

journal_title：American journal of hematology

authors： Meizlish ML,Goshua G,Liu Y,Fine R,Amin K,Chang E,DeFilippo N,Keating C,Liu Y,Mankbadi M,McManus D,Wang SY,Price C,Bona RD,Ochoa Chaar CI,Chun HJ,Pine AB,Rinder HM,Siner JM,Neuberg DS,Owusu KA,Lee AI

更新日期：2021-01-21 00:00:00

abstract：:The increased adhesiveness of sickle erythrocytes (SS RBC) to endothelial cells has been confirmed in a static system utilizing fresh umbilical vein endothelium. Adherence of SS RBC to the endothelium was as great in the presence of calcium-containing buffer as when incubated in plasma. SS RBC suspended in autologous ...

journal_title：American journal of hematology

authors： Antonucci R,Walker R,Herion J,Orringer E

更新日期：1990-05-01 00:00:00

abstract：:Fourteen patients, aged 65-85 years, with refractory (11) or relapsing (3) multiple myeloma were treated with a "protracted-sequential" protocol comprising vincristine 1-2 mg or vindesine 3 mg/M(2) (max. 5 mg) IVI over 4 hr on D1, prednisolone 40-50 mg PO D1-14, and melphalan 2-4 mg PO or cyclophosphamide 50-100 mg PO...

journal_title：American journal of hematology

authors： Manoharan A

更新日期：2000-09-01 00:00:00

abstract：:An 18-year-old girl with a preoperative platelet count of 216,000/cmm received 3 units of stored plasma at the time of surgery. Within 6 hours her platelet count had fallen to 5,000/mm3 and hemorrhagic manifestations appeared. One of the plasma donors was found to be P1A1 negative with an anti P1A1 antibody. The recip...

journal_title：American journal of hematology

authors： Nijjar TS,Bonacosa IA,Israels LG

更新日期：1987-06-01 00:00:00

abstract：:A 13-year-old boy presented with progressive bilateral lower limb weakness due to exradural granulocytic sarcoma of the spine. After surgical decompression and radiotherapy, he remained in complete remission 6 years after initial diagnosis. The possible reasons for the favorable outcome of this unique case are discuss...

journal_title：American journal of hematology

authors： Chan JK,Lau WH,Saw D

更新日期：1986-08-01 00:00:00

abstract：:Acute Myeloid Leukemia (AML) and myelodysplasia (MDS) with chromosome 3q abnormalities have a dismal outcome either untreated or with conventional treatments. Azacitidine (AZA) is now considered as the standard of care in high-risk MDS and oligoblastic AML patients. The objective of this study was to evaluate the impa...

journal_title：American journal of hematology

authors： Wanquet A,Prebet T,Berthon C,Sebert M,Roux C,Kulasekararaj A,Micol JB,Esterni B,Itzykson R,Thepot S,Recher C,Delaunay J,Dreyfus F,Mufti G,Fenaux P,Vey N

更新日期：2015-10-01 00:00:00

abstract：:The investigation of kindreds with recurrent thrombotic disease has advanced the understanding of the mechanisms of coagulation and fibrinolysis. In those cases where an etiology has been established, congenital thrombotic disorders are associated either with deficiencies or qualitative abnormalities in inhibitors of ...

journal_title：American journal of hematology

authors： Rodgers GM,Shuman MA

更新日期：1986-04-01 00:00:00

abstract：:A new density system for the separation of human red blood cells by density-gradient centrifugation is described. The gradient medium is made with colloidal silica particles coated with polyvinylpyrrolidone suspended in aqueous solution of meglamine diatrizoate. By this method, more than 10 red-cell fractions can be s...

journal_title：American journal of hematology

authors： Vettore L,De Matteis MC,Zampini P

更新日期：1980-01-01 00:00:00

abstract：:Quantification of sickle hemoglobin (HbS) in patients with sickle cell disease (SCD) undergoing hydroxyurea or chronic transfusion therapy is essential to monitoring the effectiveness of these therapies. The clinical monitoring of %HbS using conventional laboratory methods is limited by high per-test costs and long tu...

journal_title：American journal of hematology

authors： Piety NZ,Yang X,Lezzar D,George A,Shevkoplyas SS

更新日期：2015-06-01 00:00:00

abstract：:Therapy-related acute myeloid leukemia (t-AML) arises as a late complication following antecedent solid tumors or hematologic diseases and their associated treatments. There are limited data regarding risk factors and outcomes following allogeneic hematopoietic cell transplantation (HCT) for t-AML following a prior so...

journal_title：American journal of hematology

authors： Lee CJ,Labopin M,Beelen D,Finke J,Blaise D,Ganser A,Itälä-Remes M,Chevallier P,Labussière-Wallet H,Maertens J,Yakoub-Agha I,Bourhis JH,Mailhol A,Mohty M,Savani BN,Nagler A

更新日期：2019-04-01 00:00:00

abstract：:We have characterized another subset of acute nonlymphocytic leukemia (ANLL) based on the cytogenetic and morphologic findings in a group of nine patients. Five patients had chromosomal analyses performed at the University of Chicago, two patients were studied at the All-Union Cancer Research Center in Moscow, and one...

journal_title：American journal of hematology

authors： Pearson MG,Vardiman JW,Le Beau MM,Rowley JD,Schwartz S,Kerman SL,Cohen MM,Fleischman EW,Prigogina EL

更新日期：1985-04-01 00:00:00

abstract：:The occurrence of factor VIII inhibitors in non-hemophilic patients is a rare event with a potentially lethal outcome. Despite its infrequent occurrence, the association of this inhibitor with multiple autoimmune diseases is well recognized. We report the case of a patient with the recently described autoimmune lympho...

journal_title：American journal of hematology

authors： Fang BS,Sneller MC,Straus SE,Frenkel L,Dale JK,Rick ME

更新日期：2000-07-01 00:00:00

abstract：:Neutrophil elastase (NE) is a serine protease stored in the primary granules of neutrophils that proteolytically cleaves multiple cytokines and cell surface proteins on release from activated neutrophils. Recent reports of mutations in the gene encoding this enzyme in some patients with neutropenic syndromes prompted ...

journal_title：American journal of hematology

authors： Hunter MG,Druhan LJ,Massullo PR,Avalos BR

更新日期：2003-11-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) with distinct fusion transcripts has unique clinical features. In this study, the incidence, clinical characteristics, early treatment response, and outcomes of 1,004 Chinese pediatric ALLs were analyzed. Patients with TEL-AML1 and E2A-PBX1 fusion genes or other B cell precursor ALLs...

journal_title：American journal of hematology

authors： Gao C,Zhao XX,Li WJ,Cui L,Zhao W,Liu SG,Yue ZX,Jiao Y,Wu MY,Li ZG

更新日期：2012-11-01 00:00:00

abstract：:Eighteen patients with acute nonlymphocytic leukemia (ANLL), aged 17-73 years, were treated with high-dose cytosine arabinoside (HD-Ara-C) using 3 g/m2 IV q 12 hours X 12 doses. Seven patients were treated for relapse and four (57%) obtained a complete remission with a median duration of 19.5 weeks. In nine patients, ...

journal_title：American journal of hematology

authors： Cantin G,Brennan JK

更新日期：1984-01-01 00:00:00

abstract：:In HIV-positive patients with non-Hodgkin lymphoma (NHL), no benefit of adding rituximab to chemotherapy was seen in a randomized controlled trial (RCT). We performed a meta-analysis of prospective studies to ascertain outcomes in HIV-positive NHL patients treated with chemotherapy (chemo) versus rituximab and chemo (...

journal_title：American journal of hematology

authors： Castillo JJ,Echenique IA

更新日期：2012-03-01 00:00:00

abstract：:The effect of heparin on platelet aggregation was systematically examined on platelets in plasma (PRP), as well as on gel-filtered, washed, and formaldehyde-fixed platelets. Results indicate that, although heparin causes a mild potentiation of platelet aggregation in the PRP systems, a significant inhibitory activity ...

journal_title：American journal of hematology

authors： Saba HI,Saba SR,Morelli GA

更新日期：1984-10-01 00:00:00