Tachykinins potentiate N-methyl-D-aspartate responses in acutely isolated neurons from the dorsal horn.

abstract：:The first calpain protease was discovered over 40 years ago now, yet despite the vast amount of literature that has subsequently emerged detailing their involvement in the pathophysiology of a variety of human diseases, it is only in the last decade that calpain-mediated actions along the secretory pathway have begun ...

journal_title：Journal of neurochemistry

authors： Evans JS,Turner MD

更新日期：2007-11-01 00:00:00

abstract：:The excitant amino acid, N-methyl-D-aspartate, was actively taken up by slices of rat cerebral cortex. This uptake was Na+- and temperature-dependent, but was relatively inefficient (Km 3 mM, Vmax 0.07 mumol/g/min) compared with that of other acidic amino acids. The uptake of N-methyl-D-aspartate does not appear to ha...

journal_title：Journal of neurochemistry

authors： Skerritt JH,Johnston GA

更新日期：1981-03-01 00:00:00

abstract：:A reporter epitope was inserted at 11 positions in a region encompassing proposed transmembrane segments S1 and S2 in the second repeat domain (D2) of the rat skeletal muscle type 1 sodium channel. All mutations produced full-length membrane-associated protein following transfection into cultured cells, although the l...

journal_title：Journal of neurochemistry

authors： Kraner SD,Filatov GN,Sun W,Bannerman P,Lindstrom J,Barchi RL

更新日期：1998-04-01 00:00:00

abstract：:Most biological effects of tissue plasminogen activator (tPA), such as fibrinolysis, are mediated by its protease activity. Recent studies, however, have demonstrated that tPA also has several protease-independent effects such as: neuroprotection, microglial activation, and promoting LTP formation. In order to gain a ...

journal_title：Journal of neurochemistry

authors： Lee HY,Hwang IY,Im H,Koh JY,Kim YH

更新日期：2007-06-01 00:00:00

abstract：:Studies performed over the past several years have provided evidence that phosphorylation of proteins is important in the regulation of neurotransmitter release. In this study, it is shown that rabphilin-3A is present in cerebellar granule cells as a phosphoprotein, by using 32P-labeling of cerebellar granule cells, i...

journal_title：Journal of neurochemistry

authors： Fykse EM

更新日期：1998-10-01 00:00:00

abstract：:Carboxypeptidase E (CPE) functions in the posttranslational processing of bioactive peptides. Like other peptide processing enzymes, CPE is initially produced as a precursor ("proCPE") that undergoes posttranslational processing at a site containing five adjacent Arg residues near the N-terminus and at other sites nea...

journal_title：Journal of neurochemistry

authors： Song L,Fricker L

更新日期：1995-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative pathology characterized by aggregates of amyloid-β (Aβ) and phosphorylated tau protein, synaptic dysfunction, and spatial memory impairment. The Wnt signaling pathway has several key functions in the adult brain and has been associated with AD, mainly as a neuroprotectiv...

journal_title：Journal of neurochemistry

authors： Tapia-Rojas C,Inestrosa NC

更新日期：2018-02-01 00:00:00

abstract：:Previous work in this laboratory has shown that adrenal medullary transplants into the spinal cord subarachnoid space can reduce pain sensitivity. This analgesia most likely results from the release of neuroactive substances, particularly catecholamines and opioid peptides, from the transplanted cells into the CSF of ...

journal_title：Journal of neurochemistry

authors： Sagen J,Kemmler JE,Wang H

更新日期：1991-02-01 00:00:00

abstract：:To examine whether the mitogen-activated protein kinase (MAPK) cascade and phospholipase A2 (PLA2) are involved in the signal transduction mechanism of the opioid receptor, the delta-, mu-, and kappa-opioid receptors were stably expressed from cDNA in Chinese hamster ovary cells. Activation of the delta-, mu-, and kap...

journal_title：Journal of neurochemistry

authors： Fukuda K,Kato S,Morikawa H,Shoda T,Mori K

更新日期：1996-09-01 00:00:00

abstract：:Plasma osmolality and the levels of water, taurine, and total amino nitrogen (detected as ninhydrin-positive substances) have been measured in the cerebral cortices of nonpregnant and 19-day pregnant Wistar rats. Plasma osmolality fell by 11 mosmol/kg during pregnancy. Brain water content remained unaltered, but level...

journal_title：Journal of neurochemistry

authors： Law RO

更新日期：1989-07-01 00:00:00

abstract：:Protein synthesis in the brain is known to be affected by a wide range of treatments. The detailed analysis of the mechanisms that are involved would be facilitated by the development of cell-free translation systems derived from brain tissue. To date, brain cell-free systems have not been fully characterized to demon...

journal_title：Journal of neurochemistry

authors： Cosgrove JW,Brown IR

更新日期：1981-03-01 00:00:00

abstract：:Latanoprost was first developed for use in glaucoma therapy as an ocular hypotensive agent targeting the prostaglandin F2α (FP) receptor. Subsequently, latanoprost showed a neuroprotective effect, an additional pharmacological action. However, although it is well-known that latanoprost exerts an ocular hypotensive eff...

journal_title：Journal of neurochemistry

authors： Yamamoto K,Sato K,Yukita M,Yasuda M,Omodaka K,Ryu M,Fujita K,Nishiguchi KM,Machida S,Nakazawa T

更新日期：2017-02-01 00:00:00

abstract：:Math2 (NEX-1/NeuroD6) is a member of the basic helix-loop-helix transcription factor family and is involved in neuronal differentiation and maturation. In this study, we identified the genes targeted by Math2 using DNA microarrays and cultured rat cortical cells transfected with Math2. Of the genes regulated by Math2,...

journal_title：Journal of neurochemistry

authors： Yamada M,Shida Y,Takahashi K,Tanioka T,Nakano Y,Tobe T,Yamada M

更新日期：2008-09-01 00:00:00

abstract：:The regional distribution of inositol 1,4,5-trisphosphate (InsP3), inositol 1,3,4,5-tetrakisphosphate (InsP4), and ryanodine binding sites has been characterised and compared in the rat brain using radioligand binding assays. Cortical [3H]InsP3 binding indicated similar positional and stereospecificity as observed in ...

journal_title：Journal of neurochemistry

authors： Smith SM,Nahorski SR

更新日期：1993-05-01 00:00:00

abstract：:OPA1, a nuclear encoded mitochondrial protein causing autosomal dominant optic atrophy, is a key player in mitochondrial fusion and cristae morphology regulation. In the present study, we have compared the OPA1 transcription and translation products of different mouse tissues. Unlike in humans, we found only two exons...

journal_title：Journal of neurochemistry

authors： Akepati VR,Müller EC,Otto A,Strauss HM,Portwich M,Alexander C

更新日期：2008-07-01 00:00:00

abstract：:Nitric oxide (NO) has been implicated in both the pathogenesis of and protection from NMDA receptor-mediated neuronal injury. This apparent paradox has been attributed to alternate redox states of nitrogen monoxide, whereby, depending on the redox milieu, nitrogen monoxide can be neuroprotective via nitrosation chemis...

journal_title：Journal of neurochemistry

authors： Vidwans AS,Kim S,Coffin DO,Wink DA,Hewett SJ

更新日期：1999-05-01 00:00:00

abstract：:Rho family GTPases promote the survival of certain neuronal populations. However, pro-survival and pro-death signaling pathways regulated downstream of Rho GTPases are largely unknown. Cerebellar granule neurons (CGNs) exposed to Clostridium difficile toxin B (ToxB), a monoglucosyltransferase that specifically inhibit...

journal_title：Journal of neurochemistry

authors： Loucks FA,Le SS,Zimmermann AK,Ryan KR,Barth H,Aktories K,Linseman DA

更新日期：2006-05-01 00:00:00

abstract：:The critical hyaluronan binding motif (HABM) in sialoprotein associated with cones and rods (SPACR) has already been determined. As sialoproteoglycan associated with cones and rods, another interphotoreceptor matrix molecule, binds to chondroitin sulfate and heparin with or without the employment of HABMs, respectivel...

journal_title：Journal of neurochemistry

authors： Zhao J,Yoneda M,Takeyama M,Inoue Y,Kataoka T,Ohno-Jinno A,Isogai Z,Iwaki M,Zako M

更新日期：2008-11-01 00:00:00

abstract：:Prenatal and early postnatal periods are important for brain development and neural function. Neonatal insults such as hypoxia-ischemia (HI) causes prolonged neural and metabolic dysregulation, affecting central nervous system maturation. There is evidence that brain hypometabolism could increase the risk of adult-ons...

journal_title：Journal of neurochemistry

authors： Durán-Carabali LE,Kawa Odorcyk F,Greggio S,Teribele Venturin G,Farias Sanches E,Garcia Schu G,Soares Carvalho A,Avila Pedroso T,de Sá Couto-Pereira N,Costa da Costa J,Dalmaz C,Rigon Zimmer E,Netto CA

更新日期：2020-10-23 00:00:00

abstract：:Staufen is an RNA-binding protein, first identified for its role in oogenesis and CNS development in Drosophila. Two mammalian homologs of Staufen have been identified and shown to bind double-stranded RNA and tubulin, and to function in the somatodendritic transport of mRNA in neurons. Here, we examined whether Stauf...

journal_title：Journal of neurochemistry

authors： Bélanger G,Stocksley MA,Vandromme M,Schaeffer L,Furic L,DesGroseillers L,Jasmin BJ

更新日期：2003-08-01 00:00:00

abstract：:The role of neuroactive steroids and GABA(A) receptors in the generation of spontaneous spike-and-wave discharges (SWDs) was investigated in the WAG/Rij rat model of absence epilepsy. The plasma, cerebrocortical, and thalamic concentrations of the progesterone metabolite 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5a...

journal_title：Journal of neurochemistry

authors： Pisu MG,Mostallino MC,Dore R,Mura ML,Maciocco E,Russo E,De Sarro G,Serra M

更新日期：2008-09-01 00:00:00

abstract：:In Aplysia, serotonin mediates behavioral sensitization by increasing the strength of the synapse between sensory and motor neurons, a process known as facilitation. The retention of long-term facilitation is blocked by rapamycin, an inhibitor of a specific translational pathway. One possible rapamycin-sensitive targe...

journal_title：Journal of neurochemistry

authors： Carroll M,Warren O,Fan X,Sossin WS

更新日期：2004-09-01 00:00:00

abstract：:We have analyzed brain coated vesicles and synaptic plasma membrane for the presence of the plasma membrane proteolipid protein. Coated vesicles were isolated from calf brain gray matter with a final purification on Sephacryl S-1000 and reisolated twice by chromatography to ensure homogeneity. Fractions were analyzed ...

journal_title：Journal of neurochemistry

authors： Sapirstein VS,Nolan C,Stern R,Ciocci M,Masur SK

更新日期：1988-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) released from the activated microglia upon neurotropic virus infection may exacerbate the neuronal damage. Here, we identified let-7a and let-7b (let-7a/b) as one of the essential miRNAs over-expressed upon Japanese Encephalitis virus (JEV) infection and released in the culture supernatant of the JE...

journal_title：Journal of neurochemistry

authors： Mukherjee S,Akbar I,Kumari B,Vrati S,Basu A,Banerjee A

更新日期：2019-05-01 00:00:00

abstract：:Cortical areas including the anterior cingulate cortex (ACC) play critical roles in different types of chronic pain. Most of previous studies focus on the sensory inputs from somatic areas, and less information about plastic changes in the cortex for visceral pain. In this study, chronic visceral pain animal model was...

journal_title：Journal of neurochemistry

authors： Liu SB,Wang XS,Yue J,Yang L,Li XH,Hu LN,Lu JS,Song Q,Zhang K,Yang Q,Zhang MM,Bernabucci M,Zhao MG,Zhuo M

更新日期：2020-04-01 00:00:00

abstract：:Adenosine has several functions within the CNS that involve an inhibitory tone of neurotransmission and neuroprotective actions in pathological conditions. The understanding of adenosine production and release in the brain is therefore of fundamental importance and has been extensively studied. Conflicting results are...

journal_title：Journal of neurochemistry

authors： Latini S,Pedata F

更新日期：2001-11-01 00:00:00

abstract：:Parkinson's disease is a progressive neurological disorder that is characterized by the formation of intracellular protein inclusion bodies composed primarily of a misfolded and aggregated form of the protein α-synuclein. There is growing evidence that supports the prion-like hypothesis of α-synuclein progression. Thi...

journal_title：Journal of neurochemistry

authors： Tyson T,Steiner JA,Brundin P

更新日期：2016-10-01 00:00:00

abstract：:Neuromelanin is a dark brown pigment present at high concentrations in dopaminergic neurones of the human substantia nigra (SN). Early electron microscopic examinations of neuromelanin fine structure revealed a significant neutral lipid component; however, the identity of this lipid has remained unknown. Here we show ...

journal_title：Journal of neurochemistry

authors： Fedorow H,Pickford R,Hook JM,Double KL,Halliday GM,Gerlach M,Riederer P,Garner B

更新日期：2005-02-01 00:00:00

abstract：:Blood-based tests for the differential diagnosis of Alzheimer's disease (AD) are under intensive investigation and have shown promising results with regard to Abeta40 and Abeta42 peptide species in incipient AD. Moreover, plasma Abeta40 was suggested as an independent cerebrovascular risk factor candidate. These consi...

journal_title：Journal of neurochemistry

authors： Bibl M,Esselmann H,Mollenhauer B,Weniger G,Welge V,Liess M,Lewczuk P,Otto M,Schulz JB,Trenkwalder C,Kornhuber J,Wiltfang J

更新日期：2007-10-01 00:00:00

abstract：:Acidosis is a universal response of tissue to ischemia. In the brain, severe acidosis has been linked to worsening of cerebral infarction. However, milder acidosis can have protective effects. As part of our investigations of the therapeutic window in our neuronal tissue culture model of ischemia, we investigated the ...

journal_title：Journal of neurochemistry

authors： Vornov JJ,Thomas AG,Jo D

更新日期：1996-12-01 00:00:00