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Synthesis and preliminary binding studies of 4,4-ditritio-(-)-nicotine of high specific activity.

Abstract：

:4,4-Ditritio-(-)-nicotine (5) of high specific activity (4.7 Ci/mmol) has been synthesized from (-)-nicotine via the readily prepared 4,4-dibromocotinine (3). Scatchard analysis of the binding of 5 to the crude mitochondrial fraction of whole rat brain revealed a Ka of 4.7 X 10(6) M-1 and 13 fmol of binding sites/mg of protein.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Vincek WC,Martin BR,Aceto MD,Bowman ER

doi

10.1021/jm00182a028

subject

Has Abstract

pub_date

1980-08-01 00:00:00

pages

960-2

issue

8

eissn

0022-2623

issn

1520-4804

journal_volume

23

pub_type

杂志文章

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