Neural and neurochemical mechanisms of pain inhibition.

Abstract:

:Recent studies which suggest the existence of an endogenous neural substrate of pain inhibition are reviewed. Electrical stimulation of some areas of the medial brain stem in laboratory rats has produced a dramatic degree of analgesia. Such stimulation-produced analgesia is partially blocked by an opiate antagonist drug. This observation has proved seminal to those searching for endogenous opiate-like neurochemicals, the opioid peptides (enkephalins and endorphins). Particular attention is focused on studies of stimulation-produced analgesia, the underlying anatomy and physiology of endogenous analgesia systems elucidated by such work, and the relation of these findings to discoveries about opiate receptors and opioid peptides. Very recent work suggesting that certain forms of stress are natural triggers for activating endogenous analgesia mechanisms is described. Although certain stressors cause analgesia mediated by opioids, other stressors cause analgesia by neurochemically different means. Thus, multiple analgesia substrates, opioid and nonopioid, appear to exist.

journal_name

Anaesth Intensive Care

authors

Liebeskind JC,Sherman JE,Cannon T

doi

10.1177/0310057X8201000209

subject

Has Abstract

pub_date

1982-05-01 00:00:00

pages

139-43

issue

2

eissn

0310-057X

issn

1448-0271

journal_volume

10

pub_type

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