Abstract:
:The safety and efficacy of prolonged infusion of alphaxalone/alphadolone (Alfathesin: Glaxo) was assessed in 20 critically ill patients needing sedation during intermittent positive pressure ventilation in a general intensive care unit. The mean dose of Alfathesin infused was 1542 ml (range: 225 to 4820 ml) over 6.9 days (3 to 16 days) at rates between 5 and 15 ml/hour. Significant increases in plasma urea, creatinine, bilirubin, alkaline phosphatase and white cell count occurred during the infusion, but these were expected from each patient's clinical course. Lipoprotein electrophoresis invariably showed loss of the alpha band and appearance of a densely staining pre-beta band. Four patients had involuntary movements during the infusion and two patients fitted when the infusion stopped. Both had cerebral injuries. Subjective assessment of the quality of sedation was "very good" or "good" in 15 patients and "fair" in five.
journal_name
Anaesth Intensive Carejournal_title
Anaesthesia and intensive careauthors
Stewart GO,Dobb GJ,Craib IAdoi
10.1177/0310057X8301100203subject
Has Abstractpub_date
1983-05-01 00:00:00pages
107-12issue
2eissn
0310-057Xissn
1448-0271journal_volume
11pub_type
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