Relative effectiveness of 241Am vs 226Ra approached by haemopoietic stem cell studies in various bone marrow sites of contaminated mice.

Abstract:

:Haemopoietic stem cell assays allow investigation of local radiation damage at any time after contamination. These techniques were used to determine the relative effectiveness of 241Am and 226Ra in inducing damage in various cortical and trabecular bone marrow sites. Male Balb/c mice were injected with either 230 or 660 kBq 226RaCl2/kg body weight or with one of three doses of monomeric 241Am citrate at 138, 552 or 768 kBq 241Am/kg body weight. At 7 time intervals after injection (from 4 hr to 100 days) the colony-forming capacity of pluripotent stem cells (= CFU-s) and macrophage-granulocyte committed stem cells (CFU-c) was assayed in sternal marrow, marrow of lumbar vertebrae, of the trabecular distal end of the femur and of the femoral shaft (in which were distinguished axial marrow and marrow situated peripherally near the cortical bone). 226Ra retention and 241Am retention were measured in these bone sites. Skeletal doses and doses to the bone marrow sites were calculated. On the base of injected activity, 241Am was more effective than 226Ra in reducing the number of CFU-s and CFU-c but the effectiveness varied in the various bone marrow sites. CFU-s and CFU-c response is considered in relation to the retained radioactivity in the surrounding bone matrix and in relation to the mean marrow dose.

journal_name

Health Phys

journal_title

Health physics

authors

Schoeters GE,Vanderborght OL

doi

10.1097/00004032-198306001-00054

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

555-70

eissn

0017-9078

issn

1538-5159

journal_volume

44 Suppl 1

pub_type

杂志文章
  • Psychosocial and health impacts of uranium mining and milling on Navajo lands.

    abstract::The uranium industry in the American Southwest has had profoundly negative impacts on American Indian communities. Navajo workers experienced significant health problems, including lung cancer and nonmalignant respiratory diseases, and psychosocial problems, such as depression and anxiety. There were four uranium proc...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3182243a7a

    authors: Dawson SE,Madsen GE

    更新日期:2011-11-01 00:00:00

  • Rapid urinary output normalization method using specific gravity.

    abstract::Spot urine samples are often taken for emergency radiobioassay to provide a quick dose assessment for contaminated individuals. The subsequent dosimetric analysis requires a urinary output normalization method to adjust spot sampling to daily urine excretion. A rapid specific gravity method that was developed for 24-h...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e318213be69

    authors: Dai X,Kutschke K,Priest N

    更新日期:2011-08-01 00:00:00

  • Navajo birth outcomes in the Shiprock uranium mining area.

    abstract::The role of environmental radiation in the etiology of birth defects, stillbirths, and other adverse outcomes of pregnancy was evaluated for 13,329 Navajos born at the Public Health Service/Indian Health Service Hospital in the Shiprock, NM, uranium mining area (1964-1981). More than 320 kinds of defective congenital ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199211000-00005

    authors: Shields LM,Wiese WH,Skipper BJ,Charley B,Benally L

    更新日期:1992-11-01 00:00:00

  • Reassessment of Internal Thyroid Doses to 1,080 Children Examined in a Screening Survey after the 2011 Fukushima Nuclear Disaster.

    abstract::The dose reconstruction of populations potentially affected by the accident at the Fukushima Daiichi nuclear power plant in March 2011 is of great importance. However, it has been difficult to assess internal thyroid doses to Fukushima residents (mainly from their intake of I) due to the lack of direct measurements. F...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001125

    authors: Kim E,Yajima K,Hashimoto S,Tani K,Igarashi Y,Iimoto T,Ishigure N,Tatsuzaki H,Akashi M,Kurihara O

    更新日期:2020-01-01 00:00:00

  • Use of epidemiological data and direct bioassay for prioritization of affected populations in a large-scale radiation emergency.

    abstract::Following a radiation emergency, evacuated, sheltered or other members of the public would require monitoring for external and/or internal contamination and, if indicated, decontamination. In addition, the potentially-impacted population would be identified for biodosimetry/bioassay or needed medical treatment (chelat...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31821dd9a2

    authors: Miller CW,Ansari A,Martin C,Chang A,Buzzell J,Whitcomb RC Jr

    更新日期:2011-08-01 00:00:00

  • Gas mixing for achieving suitable conditions for single point aerosol sampling in a straight tube: experimental and numerical results.

    abstract::Experimental measurements of velocity and tracer gas concentration are taken in a straight tube to evaluate the effectiveness of mixing in achieving conditions as required by ANSI N13.1-1999 for single point extractive sampling from stacks and ducts of nuclear facilities. Mixing is evaluated for inlet turbulent intens...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200301000-00007

    authors: Anand M,McFarland AR,Rajagopal KR

    更新日期:2003-01-01 00:00:00

  • The Canadian whole body counting intercomparison program: a summary report for 1989-1993.

    abstract::The Human Monitoring Laboratory, which is the Canadian National Calibration Reference Centre for In-Vivo Measurements, has been conducting an annual intercomparison program for whole body counting facilities since 1989. Each year a number of phantoms are prepared for participants to measure the accuracy, precision, si...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199510000-00018

    authors: Kramer GH

    更新日期:1995-10-01 00:00:00

  • Dose-dependent analysis of acute medical effects of mixed neutron-gamma radiation from selected severe 235U or 239Pu criticality accidents in USSR, United States, and Argentina.

    abstract::Eight of the most severe cases of acute radiation disease (ARS) known to have occurred in humans (as the result of criticality accidents) had survival times less than 120 h (herein defined as "early death"). These accidents were analyzed and are discussed with respect to the specific accident scenarios and the resulti...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31823b4b78

    authors: Barabanova T,Wiley AL,Bushmanov A

    更新日期:2012-04-01 00:00:00

  • Uptake of 244Cm, 238Pu and other radionuclides by trees inhabiting a contaminated flood plain.

    abstract::The plant uptake of 244Cm, 137Cs, 238Pu and 90Sr was measured for trees in a flood plain forest whose soils were contaminated by aqueous discharges from a nuclear-fuel chemical separations facility. Uptake of the naturally occurring radionuclide 226Ra was also measured. The relative availability of the nuclides was 23...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198409000-00003

    authors: Pinder JE 3rd,McLeod KW,Alberts JJ,Adriano DC,Corey JC

    更新日期:1984-09-01 00:00:00

  • Radon awareness and mitigation in Vermont: a public health survey.

    abstract::Radon exposure is associated with an increased incidence of lung cancer, and elevated levels may be found in as many as 1 out of 15 homes. The U.S. EPA recommends testing homes for radon and mitigating over the advisory level of 4 picocuries per liter (4 pCi L(-1), or 148 Bq m(-3)). A sample population from a list of ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000254862.50407.4a

    authors: Riesenfeld EP,Marcy TW,Reinier K,Mongeon JA,Trumbo CW,Wemple BE,Kaminsky DA

    更新日期:2007-05-01 00:00:00

  • Trends in radiation protection of medical workers.

    abstract::Medical workers constitute the largest group of individuals occupationally exposed to radiation, and their collective dose equivalent is exceeded only by persons employed in the nuclear fuel cycle. Although medical workers have increased in number by about 50% over the past two decades, their collective dose has stead...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199003000-00002

    authors: Hendee WR,Edwards FM

    更新日期:1990-03-01 00:00:00

  • Cancer mortality around La Hague nuclear facilities.

    abstract::Cancer death rates from the Beaumont-Hague "canton," where a nuclear facility is located, were compared with those for the Manche "département." No significant increase was found in cancer deaths during 1970-1982 for leukemias and in 1975-1982 for all other types of malignant tumors. ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198906000-00005

    authors: Dousset M

    更新日期:1989-06-01 00:00:00

  • 239,240Pu and inorganic substances in aerosols from the vicinity of a waste isolation pilot plant: the importance of resuspension.

    abstract::Aerosol samples were collected and analyzed to characterize the spatial and temporal variations in the concentrations of plutonium and selected inorganic substances in the atmosphere around the Waste Isolation Pilot Plant (WIPP). High-volume aerosol sampling was conducted at three sites: (1) On Site, (2) Near Field, a...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200210000-00003

    authors: Arimoto R,Kirchner T,Webb J,Conley M,Stewart B,Schoep D,Walthall M

    更新日期:2002-10-01 00:00:00

  • Comparison of the needs for biodosimetry for large-scale radiation events for military versus civilian populations.

    abstract::The aim of this paper is to compare and contrast the needs for biodosimetry for initial triage for military forces and civilian populations when there are radiation exposures that involve potentially a large number of persons. Several differences in the likely scenarios for exposure of military forces include a greate...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000069

    authors: Swartz HM,Flood AB,Williams BB,Meineke V,Dörr H

    更新日期:2014-06-01 00:00:00

  • Cost-Benefit of Final Radiological Survey Versus Radioactive Waste Disposal.

    abstract::ABSTRACT A significant portion of the cost for D&D is related to low-level waste disposal, decontamination, and final radiological survey. For that reason, a careful cost-benefit analysis must be performed weighing the cost of decontaminating and radiologically surveying the building media for release against the cost...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:

    authors: Barroso J,Roberts S

    更新日期:2003-02-01 00:00:00

  • Dose estimation of a soft X-ray exposure incident.

    abstract::A dose reconstruction was carried out on a case in which a worker was exposed to soft x rays using time motion studies, an ionization chamber for low energy photon measurements, and CdZnTe (CZT) spectrometry. The worker estimated his dose to be over 600 mSv. However, the doses to the skin and testes were evaluated to ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000223464.88363.58

    authors: Suzuki T,Matsumoto M,Kim E,Yajima K,Akashi M,Fujimoto K

    更新日期:2006-08-01 00:00:00

  • Operational experience of continuous air monitoring of smoke for ²³⁹Pu during a wildfire.

    abstract::Smoke from a wildfire in northern New Mexico that moved along the border of the Los Alamos National Laboratory (LANL) was monitored for ²³⁹Pu in the event that the fire might cross into LANL property containing locations with low, but greater than background, levels of ²³⁹Pu and other alpha-emitting radionuclides. Thr...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e318259f286

    authors: Whicker JJ,Baltz D,Eisele WF,Hart OF,McNaughton MW,Green AA

    更新日期:2012-08-01 00:00:00

  • Does tributyl phosphate influence the radiation risk of a highly proliferating system--the early mouse embryo in vitro?

    abstract::Two-cell mouse embryos were exposed in vitro to tributyl phosphate, x rays, or a combination of both. In-vitro development of the embryos was followed microscopically (cleavage to four- and eight-cell embryos, formation of morulae and blastocysts, and hatching of blastocysts). Effects on proliferation were estimated b...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198712000-00009

    authors: Müller WU,Streffer C,Markoski L

    更新日期:1987-12-01 00:00:00

  • Environmental distribution and behavior of 3H and 14C around Wolsong Nuclear Power Plants.

    abstract::To estimate of the dispersion trend of 3H and 14C discharged from the Wolsung Nuclear Power Plants, the present level of 3H and 14C in environmental samples in the vicinity of the Wolsong site was studied. Tree-ring cellulose analyses were carried out for retrospective evaluation of 3H and 14C in the environment aroun...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200006000-00013

    authors: Kim CK,Lee SK,Rho BH,Lee YG

    更新日期:2000-06-01 00:00:00

  • Radiation dose to the population of Slovak Republic from diagnostic nuclear medicine.

    abstract::This study estimated the radiation exposure attributed to nuclear medicine examinations during the period of 1985 through 1992 in Slovak Republic. It was accomplished by survey of nuclear medicine facilities from 1987 to 1992. In addition, a detailed analysis of nuclear medicine practice was obtained for 1992. The mea...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199507000-00003

    authors: Ftácniková S,Ragan P

    更新日期:1995-07-01 00:00:00

  • Development of a compact electron spin resonance system for measuring ESR signals of irradiated fingernails.

    abstract::The aims of this study were to develop and improve the sensitivity of an electron spin resonance (ESR) spectrometer and to demonstrate its functionality for dosimetry in measuring ESR signals from radiation-exposed fingernails. The newly-developed spectrometer was a lightweight (22 kg) one-box ESR device with a resona...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000348019.70058.a0

    authors: Suzuki H,Tamukai K,Yoshida N,Ohya H,Kato K,Anzai K,Swartz HM

    更新日期:2010-02-01 00:00:00

  • A multidetector alpha spectroscopy analysis system.

    abstract::This document describes the attributes of an alpha spectroscopy counting and analysis system called Low Level Pulse Height Analysis (LLPHA). It was developed for multi-sample alpha spectroscopy analysis. The LLPHA system is controlled by a MIK-11/2 microcomputer with 28K of memory and uses a double-density, dual flopp...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198403000-00014

    authors: Guilmette RA,Archibeque FA

    更新日期:1984-03-01 00:00:00

  • Assessment of the natural radioactivity in the Brazilian state of Rio Grande do Norte.

    abstract::Fifty-one soil samples were collected to a depth of 30 cm in the central and eastern region of the Brazilian state of Rio Grande do Norte. Concentrations of background radionuclides in soil samples were determined by gamma ray spectrometry with an HPGe detector. The average concentrations of 226Ra, 232Th, and 40K in t...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199309000-00008

    authors: Malanca A,Pessina V,Dallara G

    更新日期:1993-09-01 00:00:00

  • Whole-body retention and tissue distribution of 60Co in rats after oral administration of freshwater fish contaminated with 60Co.

    abstract::The purpose of this report is to compare the whole-body retention and tissue distribution in rats of 60Co administered by gavage as inorganic 60CoCl2 or in a form incorporated into freshwater fish. Orizias latipes were placed in vessels containing 21. of tap water with radioactive cobalt. Periodically thereafter the f...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198208000-00007

    authors: Inaba J,Nishimura Y,Kimura K,Ichikawa R

    更新日期:1982-08-01 00:00:00

  • Visualizing High-Order Decay after Disequilibria.

    abstract::High-order decay equations are often difficult to study without significant care taken with variables and assumptions. As parent and progeny activities evolve over time, the effects of uncertainties and approximations confound the quality and interpretation of results. Of particular concern is the situation when decay...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000926

    authors: Wilson CA 4th,Hendrickson KR,Hamideh AM,Matthews KL 2nd,Wang WH

    更新日期:2018-12-01 00:00:00

  • Elimination of tritiated thymidine from birds.

    abstract::The kinetics with which tritiated thymidine is eliminated from birds and the concentration of radioactivity remaining in the carcass after 350-430 h were measured. Birds injected with tritiated thymidine eliminated 98% of the radioactivity injected within 28 h. Ninety-eight percent was identified in the excreta, and l...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199704000-00017

    authors: Party E,Barnea A,Linins I,Gershey EL

    更新日期:1997-04-01 00:00:00

  • Mayak worker dosimetry study: an overview.

    abstract::The Mayak Production Association (MPA) was the first plutonium production plant in the former Soviet Union. Workers at the MPA were exposed to relatively large internal radiation intakes and external radiation exposures, particularly in the early years of plant operations. This paper describes the updated dosimetry da...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000266071.43137.0e

    authors: Vasilenko EK,Khokhryakov VF,Miller SC,Fix JJ,Eckerman K,Choe DO,Gorelov M,Khokhryakov VV,Knyasev V,Krahenbuhl MP,Scherpelz RI,Smetanin M,Suslova K,Vostrotin V

    更新日期:2007-09-01 00:00:00

  • Enhanced Radioactive Material Source Security.

    abstract::Requirements for additional security measures for sealed radioactive sources have evolved since they were first implemented after the terrorist events of 11 September 2001. This paper will describe the sequence of those measures, commencing with the early orders issued by the U.S. Nuclear Regulatory Commission to the ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000397

    authors: Klinger JG

    更新日期:2016-02-01 00:00:00

  • The U.S. government's medical countermeasure portfolio management for nuclear and radiological emergencies: synergy from interagency cooperation.

    abstract::Following the attacks of 11 September 2001, emergency preparedness within the U.S. Department of Health and Human Services, as well as at the Department of Defense and other federal agencies, received higher visibility, new mandates and increased funding. Emergency deployment teams increased the frequency of drills to...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3182135fba

    authors: Grace MB,Cliffer KD,Moyer BR,Coleman CN,Prasher JM,Hatchett R,Mercier J,Manning RG,Bader JL,Disbrow GL,Kovacs GR

    更新日期:2011-09-01 00:00:00

  • Characterization of exposures to workers covered under the U.S. Energy Employees Compensation Act.

    abstract::Since the mid-1940s, hundreds of thousands of workers have been engaged in nuclear weapons-related activities for the U.S. Department of Energy (DOE) and its predecessor agencies. In 2000, Congress promulgated the Energy Employees Occupational Illness Compensation Program Act of 2000 (EEOICPA), which provides monetary...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000008

    authors: Neton JW

    更新日期:2014-02-01 00:00:00