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Efficient direct chromosome analyses and enzyme determinations from chorionic villi samples in the first trimester of pregnancy.

Abstract：

:Chorionic villi were obtained by an aspiration technique which proved to be the best of four alternative procedures. We report in detail the series of experiments which led to (1) successful, rapidly growing cell cultures practically free of maternal cell contamination (the use of hormone-supplemented Chang medium greatly increased the growth rate); (2) an efficient direct method to obtain high quality metaphases from the Langhans cells of the cytotrophoblast tissue and with which the fetal karyotype is defined within a few hours of chorionic villi sampling; and (3) successful testing for the activity of eight enzymes directly from the villi samples, thus showing that this material is suitable for a rapid, direct diagnosis of the related metabolic diseases.

journal_name

Hum Genet

journal_title

Human genetics

authors

Simoni G,Brambati B,Danesino C,Rossella F,Terzoli GL,Ferrari M,Fraccaro M

doi

10.1007/BF00274761

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

349-57

issue

4

eissn

0340-6717

issn

1432-1203

journal_volume

63

pub_type

杂志文章

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