Abstract:
:As evidenced by a large pedigree with 21 affected members, acrokeratoelastoidosis (AKE) is an autosomal dominant skin disease (10185; McKusick 1978). Linkage with genetic markers already assigned to human chromosomes could help to map the gene for this disease. Therefore 22 markers were investigated in 61 members of the AKE family. Loose linkage is possible between AKE and ACP1, IGKC, and Jk, but the estimated recombination fractions do not reach significant deviations from 0.5. However, since the three marker loci have been previously assigned to chromosome 2, the AKE locus might be assigned tentatively to the same chromosome. Of the provisionally and inconsistently assigned markers, only blood group P is seen to be in linkage with HLA.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Greiner J,Krüger J,Palden L,Jung EG,Vogel Fdoi
10.1007/BF00284653subject
Has Abstractpub_date
1983-01-01 00:00:00pages
222-7issue
3eissn
0340-6717issn
1432-1203journal_volume
63pub_type
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